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Can your diet rewire your metabolism? scientists investigate

NCT ID NCT02298725

Knowledge-focused Sponsor: USDA, Western Human Nutrition Research Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured changes in insulin sensitivity, cholesterol, and other blood markers. The goal was to understand how diet composition can influence disease risk, even when calories stay the same.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Dec 2014

Finished

Mar 2017

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Premenopausal by self-report * Body Mass Index 25-39.9 kg/m2 * Fasting glucose ≥100 and \<126 mg/dL and/or * Oral Glucose Tolerance Test (OGTT) 2-hour glucose ≥140 and \<199 mg/dL and/or * Quantitative insulin sensitivity check index (QUICKI) score \<0.315 and/or * Homeostasis Model Assessment (HOMA) \>3.67, or log HOMA \>0.085 and/or * Glycated Hemoglobin HbA1c ≥5.7 and \<6.5fasting glucose ≥100 and \<126 mg/dL and/or * Fasting triglyceride concentrations \>150 mg/dL and/or * LDL cholesterol \>100 mg/dL and/or * HDL cholesterol \<40 mg/dL. Exclusion Criteria: * BMI \<25 and \>39.9 kg/m2 * Presence of any metabolic diseases, by self-report * Gastrointestinal disorders by self-report * Presence of cancer or other serious chronic disease by self-report * Current use of prescribed or over the counter weight loss medications * Pregnant * Lactating * Current use of tobacco * Moderate or strenuous physical activity \>30 min/day, 5 or more days per week * Weight change \>5% of body weight during the previous 6 months * Dietary restrictions that would interfere with consuming the intervention foods

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome Insulin Resistance metabolic syndrome X Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin resistance Metabolic syndrome X Obesity

Contacts and locations

Locations

  • Clinical Translational Science Center

    Sacramento, California, 95817, United States

  • Western Human Nutrition Research Center

    Davis, California, 95616, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.