Weight loss success often fades – new study investigates why

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion 1.65 ≥ Age ≥ 20 years-old. 2.BMI ≥ 30. 3.Once attempted exercise or dietary control. 4.No cognitive deficiency and clear communication. 5. No severe psychotic disorders were evaluated by the psychiatrist. (e.g. schizophrenia, bipolar disorder, or severe depression). 6\. Signing the informed consent form for clinical trials. Exclusion 1. Once underwent bariatric surgery. 2. Once used the GLP-1 receptor agonist. 3. Pregnancy or preparation for pregnancy. 4. Once and presenting gastric cancer. 5. Presenting the other cancer. 6. The abnormal endocrine system causes diseases with obesity. 7. Major organ abnormalities (e.g., kidney failure, liver failure, heart failure, etc.). 8. Gastric ulcer, and severe gastroesophageal reflux. 9. Severe psychiatric disorders (schizophrenia, severe bipolar disorder, and depression, etc.). 10. Bulimia nervosa or anorexia nervosa. 11. Drug and alcohol abuse. 12. Helicobacter pylori is not for bariatric surgery. 13. The following diseases or conditions preclude the use of Contrave: 1)Uncontrolled hypertension, 2) History or current diagnosis of epilepsy, 3) Allergy to this medication, 4) Medications evaluated by a physician to interact with this drug (antidepressants, antipsychotics, liver medications, heart medications). 14. The following diseases or conditions preclude the use of GLP-1 medication: 1) History or current diagnosis of medullary thyroid carcinoma, 2)History or current diagnosis of Multiple Endocrine Neoplasia syndrome type 2, 3)Allergy to this medication, 4)Medications evaluated by a physician to interact with this drug (antidepressants, antipsychotics, liver medications, heart medications). 15. The following diseases or conditions preclude the use of Xenical medication: 1) History or current diagnosis of cholestasis, 2) Allergy to this medication, 3) Medications evaluated by a physician to interact with this drug (antidepressants, antipsychotics, liver medications, heart medications).