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What makes us overeat? new study probes Obesity's hidden triggers

NCT ID NCT00342732

Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 17, 2026 · Updated 16 times

Summary

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake measurements. The goal was to understand genetic and environmental factors behind obesity risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify behavioral and genetic risk factors for obesity, potentially guiding future prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to interventions, and findings in Pima Indians may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

539 people

The number who actually took part.

Started

Nov 1999

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Residents of Phoenix metropolitan area

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion Criteria: 1. Healthy, as determined by medical history, physical examination, and laboratory tests. 2. 18-65 years old 3. Non-diabetic status Exclusion Criteria: 1. Hypo- or hyper-thyroid 2. Blood pressure greater than 160/95 3. Cardiovascular disease 4. Gallbladder disease 5. Alcohol and/or current use of drugs (more than 2 drinks per day and regular use of drugs such as amphetamines, cocaine, or heroin) 6. Psychiatric conditions or behavior that would be incompatible with safe and successful participation in this study, including claustrophobia and eating disorders such as anorexia or bulimia nervosa 8\. Use of medications affecting metabolism and appetite 9\. Pregnancy 10\. Current use of nicotine products, including tobacco, electronic cigarettes, and nicotine replacement therapies that exceed Very Low Dependence on the Fagerstr(SqrRoot)(Delta)m Test for Nicotine Dependence Tool (score greater than 2). Subjects may be excluded or withdrawn from the study if they have any conditions not specifically mentioned above that may interfere with the collection of the food intake. This includes such issues as not following study and unit policies and procedures, diagnosis of contraindications following admission, and development of illness/infection unrelated to the study. For example, volunteers who do not comply with the vending machine protocol (i.e., share food, do not record what they eat, eat outside of room, etc) may be withdrawn from the study.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder overnutrition Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Overnutrition Overweight

Contacts and locations

Locations

  • NIDDK, Phoenix

    Phoenix, Arizona, 85014, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.