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Can exercising with less oxygen burn more fat?

NCT ID NCT07814599

Knowledge-focused Sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are comparing two sessions of high-intensity interval training on a stationary bike in adults with overweight or obesity. In one session, participants breathe air with less oxygen than normal; in the other, they breathe regular air. The study measures oxygen use, fat and carbohydrate burning during exercise and recovery, plus appetite and food intake over the next day. The goal is to understand whether low-oxygen exercise changes metabolism or appetite in ways that could matter for weight management.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-intensity interval training on a stationary bike, performed either with reduced oxygen in the air or normal oxygen
What this could lead to
If low-oxygen exercise changes how the body burns fat or controls appetite, it could shape future exercise programs for weight management.
What could go wrong
This is a small, short-term study of 18 people that measures metabolism during and after single exercise sessions. It cannot show whether low-oxygen training leads to lasting weight loss, and breathing reduced oxygen may feel harder or cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Nov 2024

Finished

Sep 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- overweight or obesity (BMI between 25 kg/m2 and 35 kg/m2) Exclusion Criteria: * medical contraindications to intense physical activity * taking ß-blocker * diabete * women taking hormonal replacement therapy

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Conditions

The condition(s) this trial relates to.

Hypoxia Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Energy expenditure Obesity & overweight Substrate oxidation

Contacts and locations

Locations

  • CREPS Auvergne Rhône-Alpes / Vichy

    Bellerive-sur-Allier, Allier, 03321, France

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