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Time-Restricted eating may slow aging in overweight adults

NCT ID NCT05880095

Knowledge-focused Sponsor: IMDEA Food Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction or time restriction for six months. Researchers measured changes in metabolism, body composition, sleep, mood, and molecular markers of aging to see if time-restricted eating offers unique benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
time-restricted eating (TRE) combined with a Mediterranean diet
What this could lead to
If successful, this could point toward a simple dietary pattern that promotes healthier aging without requiring calorie counting.
What could go wrong
This is a small, completed study with no phase designation, so results are preliminary. The effects may not apply to people without overweight or liver issues, and long-term benefits remain unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

176 people

The number who actually took part.

Started

Jul 2023

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI: 27-35 Kg/m2 * Prevalent fatty liver disease (FLI \> 59 or echography screening) EASL, Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease, 2016. * Habitual daily eating window ≥ 14 h * Regular sleeping patterns (7 ± 2 sleeping hours every day) * Stable weight during the last 3 months (weight changes ≤ 4 Kg) * Not considering changes in thei physical activity in the following 6 months * Not being under a weight-loss program or medication. Exclusion Criteria: * Non-menopausal women * Alcohol abuse (CAGE score \> 2, Ewing, 1984; Malet et al. 2005) * Change in smoking habits in the previous 6 months. * Prevalent renal, cardiovascular, liver (excluding fatty liver), endocrine o pancreatic disease. * Type 1 diabetes * Type 2 diabetes with poor glucose control. * Poorly control hypertension. * Medical treatment affecting weight or sleep. * Food allergies or intolerances affecting the adherence to the intervention. * Eating disorders. * Shift workers. * Participants of other studies. * Social factors affecting to the adherence to the intervention (being institutionalized, unable to ingest solid food).

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Conditions

The condition(s) this trial relates to.

Intermittent Fasting metabolic dysfunction-associated steatotic liver disease Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biological aging

Contacts and locations

Locations

  • IMDEA Food

    Madrid, Madrid, 28049, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.