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Pre-Pregnancy weight loss may boost Baby's health, study finds

NCT ID NCT03244722

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study tested whether a very low energy diet (800 calories a day using meal replacements) before pregnancy could improve the health of obese women and their babies. 147 women participated, including those with obesity and healthy-weight women for comparison. Researchers measured weight loss, metabolic changes, and baby's body fat at birth to see if the diet made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Very-low energy Diet (VLED) using liquid meal replacements
What this could lead to
If successful, this could show that losing weight before pregnancy improves the health of both mother and baby, potentially reducing future obesity risk in children.
What could go wrong
This is an early-stage observational study with only 147 participants. Results may not apply to all women, and the strict diet may be hard to follow long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

147 people

The number who actually took part.

Started

Apr 2018

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI \> 30 ≤ 45 for obese participants OR * BMI ≤ 25 for healthy body weight participants * No known infertility * No known risk factors for tubal disease Exclusion Criteria: * Significant medical co-morbidities (e.g. heart, kidney, liver, autoimmune disease) * Significant anemia * Cancer other than minor skin cancers * Conditions that would complicate pregnancy * Recent use of anti-obesity drugs or appetite suppressants * Previous bariatric surgery * Endometriosis AFS (American Fertility Society classification class III or IV) * Progesterone \> 10 IU/ml * Current pregnancy * Use of sperm donor

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Conditions

The condition(s) this trial relates to.

inherited obesity Obesity obesity disorder pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity; familial Pregnancy related

Contacts and locations

Locations

  • University of Michigan

    Ann Arbor, Michigan, 48106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.