Exercise plus amino acids may trim fat in metabolic syndrome
NCT ID NCT01326416
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could reduce fat mass and improve related health measures like blood pressure and blood sugar.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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79 people
The number who actually took part.
- Start date
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Mar 2011
- Finished
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Nov 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Suffering from obesity (Body Mass Index (BMI) \> 30kg.m-2) with a maximal weight of 135 kg * Suffering from metabolic syndrome (International Federation of Diabetes(FID) definition) * Hospitalized or followed in consultation * Age 18 to 55 years old * Not having recently participated in other clinical studies during the last days before pre-inclusion consultation * Affiliated to a National Insurance scheme * Having National Social Security insurance Exclusion Criteria: * Asthma, chronic respiratory failure, obstructive chronic bronchitis * Current or recent Pneumothorax, recent pleural draining or biopsy, current hemoptysis, untreated / in course of treatment active tuberculosis * Coronaropathy, myocardiopathy, myocarditis, unstable cardiac failure, ventricular rhythm disorders * Severe Anemia * Severe inferior members Arteritis * Incapacity to walk or cycle * Severe renal failure (Creatinine Clearance \<or = 30 mL/min) * Severe Sepsis * Psychiatric Disorders (Diagnostic and Statistical Manual - Revision 4 (DSM IV) criteria) such as schizophrenia, other psychoses or major depressive non treated syndromes * Severe or non treated Eating Disorders implicated in obesity (compulsive access, bulimia) * Patients under guardianship or with curators * Women in age of procreation without means of effective contraception * Pregnant or breast-feeding women * Taking medicates such as: proteinate powder (Protifar ®, SP95 ®, Orlistat (Xenical ®, Ally ®), exenatide (Byetta ®), sitagliptin (Januvia ®, Xelevia ®), vildagliptin (Galvus ®), sitagliptin-metformin (Janumet ®), Vildagliptin-metformin (Eucreas ®), tadalafil (Cialis ®) sildenafil (Viagra ®) * Drug addiction to opiates in the last six months * Alcohol or drug abuse * Infection by Human Immunodeficiency Virus (HIV) , viral hepatitis B and viral hepatitis C * Active addiction to smoking in more than 8 cigarettes a day * Understanding badly spoken or written French * Performed, in 2 to 3 days preceding the Dual-energy X-Ray Absorptiometry (DEXA) exam, of a bone scintigraphy or a digestive tract radiological examination with the use of barium type of contrast agent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Hospital of Rouen
Rouen, 76031, France
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Other studies related to the condition(s) this trial covers.
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