Ketone pills vs. keto diet: which lowers disease risk better?
NCT ID NCT06668168
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers measured changes in blood proteins, gene activity, and other health indicators to see if ketones themselves, apart from diet, offer protective benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ketone monoester supplement and ketogenic diet
- What this could lead to
- If successful, this could help identify whether raising ketone levels safely reduces the risk of obesity-related diseases like heart disease or diabetes.
- What could go wrong
- This is a small, short-term study (69 people, 4 weeks) looking at blood markers, not actual disease outcomes. Results may not translate to long-term health benefits or apply to broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
69 people
The number who actually took part.
- Started
-
May 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Body mass index: 25-45 kg/m2 * Waist circumference \>93.9 (males) or \>79.9 (females) Exclusion Criteria: * Glucose or lipid lowering medication * Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes * Contraindications to a ketogenic diet (e.g., pancreatitis, liver failure, disorders of fat metabolism, primary carnitine deficiency, carnitine palmitoyltransferase deficiency, carnitine translocase deficiency, porphyrias, or pyruvate kinase deficiency) * Unable to understand English language
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Bath
Bath, BA2 7AY, United Kingdom
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