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Resveratrol plus diet shows promise for knee OA in obese postmenopausal women

NCT ID NCT07634302

Symptom relief Sponsor: Federal State Budgetary Scientific Institution Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, function, and markers of joint health and inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
resveratrol (a dietary supplement from Japanese knotweed)
What this could lead to
If it works, this could point toward a simple, natural supplement to boost the benefits of weight loss for knee pain and joint health in older women.
What could go wrong
This was a very short, small trial (10 days, 97 women). The results may not apply to men, longer treatment, or other populations. Resveratrol can cause mild digestive upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

97 people

The number who actually took part.

Started

Mar 2017

Finished

Sep 2018

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Postmenopausal women aged 45-75 years. * Diagnosed knee osteoarthritis. * Obesity, defined as BMI ≥30 kg/m². * Ability to comply with the study protocol and dietary recommendations. * Written informed consent to participate in the study. Exclusion Criteria: * Allergy or intolerance to grapes, wine, peanuts, resveratrol, or supplement components. * Acute infectious or inflammatory disease at screening. * Unstable or exacerbated chronic disease requiring treatment changes or hospitalization. * Malignancy within the past 5 years. * Chronic liver disease, including hepatitis or cirrhosis. * Major cardiovascular event within the past 6 months. * Alcohol abuse or dependence. * Severe psychiatric disorder or cognitive impairment limiting protocol adherence. * Use of resveratrol-containing supplements or investigational products within the past 6 months.

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Conditions

The condition(s) this trial relates to.

Inflammation Obesity obesity disorder osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (knee oa) Obesity (disorder)

Contacts and locations

Locations

  • Department of Cardiovascular Pathology and Diet Therapy

    Moscow, 115446, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.