Tracheal disorder

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This study tested a new medicine called BI 1291583 in 22 adults with cystic fibrosis bronchiectasis, a lung condition that causes coughing and infections. Participants took one tablet daily for 12 weeks, and the study checked if the medicine was safe and well-tolerated. The trial…

This completed study followed 152 COPD patients who started using a triple-combination inhaler (BGF) as part of their routine care. Researchers measured changes in symptoms and quality of life after 12 and 24 weeks. The goal was to see if the inhaler helps patients feel better an…

This study tested a drug called tozorakimab in over 1,700 people with COPD who had a history of flare-ups. The goal was to see if it could safely reduce severe breathing attacks over the long term. Participants who completed earlier trials were given either tozorakimab or a place…

This phase 2 trial tested an experimental inhaled powder called TQC3721 in 195 people with moderate to severe COPD. The goal was to see if it improves lung function and is safe compared to a placebo. Researchers measured changes in breathing capacity over four weeks.

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested a program to help smokers at high risk for COPD reduce their smoking. Over 4,200 adults aged 35 and older who smoked or had recently quit took part. The program included health checks, digital tools, and education to support quitting or cutting back. The goal wa…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This completed study tested whether omega-3 fatty acids and vitamin D supplements can improve weight, muscle mass, and fatigue in 45 people with COPD who also have cachexia (severe muscle wasting). Participants took the supplements twice daily for six weeks. The goal was to see i…

This study tested a new type of breathing machine that automatically adjusts its settings to match each person's breathing in real time. Fifteen people with severe COPD who already use a ventilator at home tried the device for six weeks. The goal was to see if the smart ventilato…

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This phase 3 trial tested whether a triple-combination inhaler (CHF 5993) works better than a standard dual inhaler (Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 700 adults aged 40 and older with a history of smoking took part. The main goal was t…

This study tested a community-based program for adults at high risk for COPD who also have other health issues like high blood pressure, diabetes, or mental health concerns. Over 9,300 participants in Xishui County were assigned to either the program or usual care. The program in…

This phase 3 trial tested whether a new inhaler (beclometasone/formoterol) works as well as an existing one (budesonide/formoterol, Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 24 weeks, 750 Chinese adults with moderate-to-severe COPD used one of …

This study tested whether mepolizumab, an asthma drug, can reduce lung inflammation and flare-ups in people with COPD who have high levels of eosinophils (a sign of asthma-like inflammation). Thirty-one participants received mepolizumab every 4 weeks for a year and had MRI scans …

This study looked at 200 people with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI. Researchers tracked changes in symptoms and lung function over 24 weeks in routine doctor visits. The goal was to see how the medicine performs outside of stric…

This study tested a 12-week internet-based aftercare program for people with COPD, starting right after they finished inpatient pulmonary rehabilitation. The program included activity tracking, online exercise training, educational modules, and therapist support via phone. Resear…

This early-stage trial tested whether EP395, an oral capsule, can reduce lung inflammation in healthy adults. All 49 participants inhaled a substance that causes temporary airway inflammation, mimicking a key feature of COPD. Researchers measured inflammation levels and collected…

This study tested whether a drug called mepolizumab, given after a severe COPD flare-up that required hospital care, could prevent future hospital stays or death. It involved 238 adults with eosinophilic COPD (a type with high levels of certain white blood cells). Participants re…

This completed study tested whether adding a daily statin (atorvastatin 20 mg) to standard treatment for six months could reduce airway inflammation and improve lung function in 80 people with severe COPD. Researchers measured blood markers of inflammation and breathing tests. Th…

This study tested whether an inhaled antibiotic (tobramycin), taken alone or with an oral antibiotic (ciprofloxacin), can permanently clear Pseudomonas aeruginosa infections from the lungs of people with bronchiectasis. The trial involved 371 adults and compared these treatments …

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants received either the drug or a placebo as a shot, while continuing their usual inhalers. The main goal was to see if the drug could reduce the number of…

This study tested a new medicine called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants received either a low or high dose of the drug or a placebo as a shot under the skin, while continuing their usual inhalers. The main goal was to …

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD who were either former or current smokers. The goal was to see if it could reduce the number of serious flare-ups and improve lung function compared to a placebo. The drug works by blocki…

This study tested a new antibody drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants received either the drug or a plac…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study tested whether switching to a stronger, extrafine triple inhaler (CHF5993) could improve lung function in 25 people with advanced COPD. Participants were current or former smokers aged 40 or older. The study used special lung imaging to measure changes in airway volume…

This Phase 3 study tested a new inhaler called HL231 in 487 Chinese adults with moderate to very severe COPD. Participants used either HL231 or the active comparator Ultibro once daily for 52 weeks. The main goal was to see if HL231 improved lung function (FEV1) after 26 weeks co…

This study tested a new implant designed to release trapped air in the lungs of people with severe emphysema or COPD. Up to 48 participants received up to two procedures to place the implants. Researchers checked if the device was safe and if it improved breathing over 12 months.

This study followed 212 adults with moderate to severe COPD in Greece who were prescribed a triple-combination inhaler (Trixeo Aerosphere). Researchers tracked why patients switched from dual therapy and how their symptoms and quality of life changed over 52 weeks. The goal was t…

This study followed 250 adults with COPD who were starting a new triple-combination inhaler (budesonide/glycopyrronium/formoterol, or BGF) in routine Italian clinics. Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see re…

This study tested whether giving live vaccines (BCG and MMR) to people with COPD can train their immune system to produce less harmful inflammation. Sixty adults with COPD received either the vaccines or a placebo. Researchers measured changes in immune cell activity over four mo…

This early-phase trial tested whether the immunosuppressant drug everolimus could help people with idiopathic subglottic stenosis, a rare condition where scarring narrows the airway. Eight participants took everolimus for 42 days after a dilation surgery to open the airway. The g…

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, are safe and can help people with moderate to severe COPD. 62 participants received either stem cells or a placebo. The main goal was to check for side effects, and researchers also looked at changes i…

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested a drug called astegolimab in over 1,300 people with COPD who have frequent flare-ups. The goal was to see if adding this drug to standard care could reduce the number of moderate to severe COPD attacks over a year. Participants were current or former smokers wit…

This study looked at how well endoscopic stenting and suturing work to close holes or tears in the esophagus. Researchers reviewed 150 patients treated at a large referral center. The goal was to see which technique leads to better healing.

This completed French registry tracked 155 adults with severe emphysema or COPD who received Zephyr Valves, tiny devices placed in the lungs to help them work better. The goal was to see if the treatment safely improves breathing over 12 months. Researchers measured lung function…

This study tested a drug called itepekimab in 312 adults with bronchiectasis (a lung condition causing chronic cough and infections). The goal was to see if it could reduce the number of moderate or severe lung flare-ups compared to a placebo. Participants received either the dru…

This study tested an inhaled medication called glycopyrrolate in 46 people with COPD. Participants received three different doses of the drug and a placebo over separate one-week periods. The goal was to see if the drug improves lung function and is safe. This is an early-stage t…

This study tested whether Trikafta, a drug already approved for cystic fibrosis, can help people with non-cystic fibrosis bronchiectasis (NCFBE). Thirty-two adults took the medication for 28 days. Researchers measured lung function, quality of life, and weight, and also looked at…

This study compared two different triple-combination inhalers (BGF and FUV) in 22 people with stable COPD. The goal was to see which one better improves small airway function. Participants used each inhaler for a period and then switched, allowing a direct comparison of their eff…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 people with COPD. The goal was to see if the triple combination improves lung function and reduces serious breathing attacks over 52 weeks. Participant…

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study tested whether inhaling a solution containing ectoin, a natural substance, can reduce inflammation in the lungs and help prevent further loss of lung function. It involved 36 postmenopausal women aged 75–80 with mild airway obstruction and signs of inflammation. Partic…

This study tested a new combination of two inhaled drugs, ensifentrine and glycopyrrolate, in 33 adults with COPD. The goal was to see how the drugs move through the body, how well they open airways, and if they are safe. Each person received single doses of the combination and e…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each me…

This study tested two different surgical methods to open a narrowed windpipe (subglottic or upper tracheal stenosis) in 30 patients. One method uses a special device to widen the airway, while the other removes scar tissue and places a small graft from the inside of the cheek. Th…

This large Phase 3 trial tested whether a daily pill called brensocatib can reduce the number of lung infections (called pulmonary exacerbations) in people with non-CF bronchiectasis, a chronic lung condition. Over 1,700 adults and adolescents took either 10 mg, 25 mg of brensoca…

This study looked at how well the Trimbow inhaler works for people with COPD when used in everyday life, not just in a lab. 362 adults with COPD used the inhaler for 12 weeks. Researchers measured changes in a COPD symptom questionnaire to see if patients felt better. The goal wa…

This study tested a new way to give Alpha-1 protein therapy by injecting it under the skin instead of into a vein. Seventeen adults with Alpha-1 Antitrypsin Deficiency received either a low or high dose weekly for eight weeks. The main goal was to check safety and how the drug mo…

This completed Phase 1 trial tested the safety of Hemay005 tablets, a potential new drug for chronic obstructive pulmonary disease (COPD), in 468 healthy Chinese adults. Researchers compared different dosing methods (titration vs. non-titration) to see how they affect side effect…

This study looked at how well a single inhaler containing three medicines (Trelegy Ellipta) works for people with chronic obstructive pulmonary disease (COPD) in real-world settings. Over 12 weeks, 463 adults aged 40 and older with ongoing COPD symptoms used the inhaler. Research…

This study tested whether a special infant formula containing lactoferrin and human milk oligosaccharides (HMOs) could improve immunity in newborns. 240 healthy full-term babies were randomly assigned to receive either the test formula, a standard formula, or breast milk for 12 m…

This study looked at whether monitoring COPD patients' home ventilators from a distance can help them use the machines more regularly and reduce hospital visits. 54 adults with COPD who were new to home ventilation took part. Some received standard care with in-person checkups ev…

This study tested whether having a pharmacist teach people with COPD about their medications could reduce sudden worsening of symptoms. 174 adults with moderate to severe COPD were given a 20-minute education session either at the hospital or at their local pharmacy, plus a 10-mi…

This study tested a once-daily inhaler called Trelegy Ellipta in 80 adults hospitalized for a COPD flare-up. The goal was to see if it reduces the need for extra rescue breathing treatments and shortens hospital stays. Participants took the inhaler daily along with short-term ste…

This Phase 2 trial tested an experimental drug called 611 in 142 Chinese adults with moderate-to-severe COPD. Participants received either 611 or a placebo as a shot under the skin every two weeks. The study measured changes in lung function and symptom scores over 16 weeks to se…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at how well the antibiotic Klacid SR works for adults with respiratory infections like bronchitis and mild pneumonia, especially in those who had taken it before. Over 3,000 participants were treated in regular doctor visits, and doctors checked if symptoms impr…

This study looked at whether adding casein protein and leucine (an amino acid) to meals could help people with COPD and healthy older adults build more muscle. Weight loss and muscle loss are common in COPD and can make the disease worse. Researchers tested different meal combina…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, can reduce the number and severity of COPD flare-ups in adults with moderate to severe COPD. A total of 198 participants were randomly assigned to receive either MV130 or a pla…

This study tested whether taking fish oil supplements (containing EPA and DHA) along with a protein drink could help people with COPD build muscle. Sixty-four participants took either fish oil or a placebo for four weeks. Researchers measured muscle protein synthesis to see if th…

This study tested whether a mobile telerehabilitation app could help people with COPD keep the benefits they gained from a short pulmonary rehab program. 200 patients were randomly assigned to use the app or receive standard care for one year. The main goal was to see if the app …

This study tested whether using HEPA air cleaners at home along with phone-based motivational interviewing could improve breathing and quality of life in smokers with COPD. 144 current smokers with COPD were randomly assigned to receive either active air cleaners and counseling o…

This phase 3 trial tested mepolizumab, a drug that targets eosinophils (a type of white blood cell), in 18 COPD patients with eosinophilic bronchitis. The goal was to see if it reduces eosinophil levels in the airways and lowers the risk of severe flare-ups. Participants received…

This study tested a new inhaler (BGF MDI HFO) delivering a triple-drug combination (budesonide, glycopyrronium, formoterol fumarate) against the current inhaler (BGF MDI HFA) in 559 people with moderate to very severe COPD. The main goal was to compare safety over 12 weeks, with …

This completed Phase 4 trial tested two mucus-thinning drugs, Taneasy and Fluimucil, in 45 adults with COPD. Participants took the granules twice daily for 14 days. The study measured how well the drugs helped clear mucus and improve breathing, using the COPD Assessment Test (CAT…

This study followed over 1,300 people with moderate to severe COPD whose symptoms were not controlled by standard dual inhalers. Researchers measured how Trimbow, a triple-combination inhaler, affected their quality of life and lung function over six months. The goal was to see i…

This study tested whether adding a digital remote monitoring system to a standard pulmonary rehabilitation program helps people with COPD. 78 participants either received the enhanced program with daily vital sign tracking or the standard program alone. The main goal was to see i…

This study tested a new scoring tool (GLORI-COPD) to see how well it can identify COPD patients at risk of serious complications, like lung infections. Researchers studied 462 smokers or former smokers aged 35 and older who had not been previously diagnosed with COPD. The goal is…

This study looked at whether a blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk: smokers and ex-smokers with COPD. Researchers combined this blood test with low-dose CT scans over three yearly screenings in 683 particip…

This study tested a special breathing technique during PET scans to get clearer images of lung tumors. 103 people with small lung nodules (under 35 mm) had both a standard PET scan and an extra scan where they held their breath. The goal was to see if this reduces blurring from b…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study tested two medications, roflumilast and azithromycin, in over 1,000 people with severe COPD and chronic bronchitis. The goal was to see which drug better prevents hospitalizations or death. Participants were current or former smokers aged 40 or older who had been hospi…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tested whether a simple balloon-blowing exercise, combined with deep breathing, could increase oxygen levels in people with mild to moderate COPD. 46 adults performed the exercises twice daily for 7 days. The results showed that those who did both balloon blowing and d…

This study tested a device that teaches people with COPD or asthma how to use their inhalers correctly. About 140 adults aged 18-85 who already use specific inhalers will be trained with either the device or standard brief instruction. The goal is to see if the device improves in…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study looked at whether a 4-week program of breathing muscle training, aerobic exercise, or both could improve breathing strength, walking ability, and well-being in women with stable COPD. 68 women aged 48-65 with mild-to-moderate COPD took part. The researchers also checke…

This study tested whether sleeping with the head and trunk raised (using an adjustable bed backrest) improves sleep quality in people with chronic obstructive pulmonary disease (COPD). Twenty-four adults with severe COPD and sleep difficulties each tried the raised position and t…

This study tested whether a home-based exercise program using an exergaming (video-game exercise) system, supervised remotely by a physiotherapist, could improve physical fitness and quality of life in people with COPD. 92 participants were randomly assigned to either the exergam…

This study tested whether taking a daily arginine supplement (Bioarginine) for 6 weeks can improve breathing and daily activities in people with COPD. 153 participants were randomly assigned to receive the supplement or a placebo on top of their usual inhaled medications. The goa…

This study tested whether singing and vocal exercises could improve lung function in people with chronic obstructive pulmonary disease (COPD). Five adults with COPD took part in virtual singing sessions twice a week for four weeks, guided by a music therapist. Researchers measure…

This study tested a new breathing support method (HVNI) against standard non-invasive ventilation (NIV) in 66 COPD patients with dangerously high carbon dioxide levels. The goal was to see if HVNI could safely lower carbon dioxide and reduce the need for a breathing tube. Results…

This study tested whether specific osteopathic techniques (rib rising and thoracic lymphatic pump) combined with a manual diaphragmatic release could improve breathing in 66 people with stable moderate-to-severe COPD, aged 60-75. Participants received the hands-on therapy, and re…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study looked at two types of vibrating devices—one that sends vibrations into the airways and one that vibrates the chest wall—to see if they could help people with COPD breathe better and sleep more soundly during a sudden worsening of their condition. 33 adults with severe…

This study tested whether an eight-week online yoga program could improve breathing, exercise ability, and quality of life in adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Seventy participants were split into a yoga group (three supervised sessions per…

This study looked at whether adding balance exercises to standard lung rehab can help prevent falls in people over 80 with COPD. 21 participants were split into two groups: one did the usual rehab, the other added balance training. The goal was to see if balance improved and fall…

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study tested whether a six-week program of breathing exercises using a device called an incentive spirometer could help older adults (65+) with COPD who were also frail. 66 participants were split into two groups: one did the breathing exercises, the other did not. After six…

This study looked at whether a combination inhaler (tiotropium/olodaterol) can improve exercise capacity in people with COPD who have overinflated lungs. 44 adults used the inhaler for 4 weeks, and researchers measured changes in oxygen use during exercise, heart function, and qu…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and their daily step counts were measured. The goal was to see if this approach improves physica…

This study tested whether using a special high-flow oxygen device during exercise training helps people with COPD breathe easier and exercise more. Thirty patients completed 12 rehab sessions, and those using the device could walk at a steeper incline on the treadmill. The approa…

This study tested two breathing techniques—Wim Hof method and box breathing—in 60 people with mild COPD. The goal was to see if these exercises could reduce anxiety and breathlessness and improve lung function. Participants practiced one of the two techniques, and researchers mea…

This study tested whether taking L-arginine and liposomal vitamin C supplements twice daily could reduce fatigue in people with COPD and chronic respiratory failure. 101 patients were randomly assigned to receive the supplements or a placebo during a 28-day pulmonary rehabilitati…

This study tested whether a 10-week digital pulmonary rehabilitation program, done at home via video calls and a smartphone app, could improve lung function, thinking skills, and sleep quality in people with chronic obstructive lung disease (COPD). Sixty stable COPD patients aged…

This study tested how well the over-the-counter medication Mucinex works for people with stable chronic bronchitis when used over 12 weeks. 82 adults aged 40 and older took part, tracking their symptoms, satisfaction, and any side effects. The goal was to see if long-term use hel…

This study tested whether teaching COPD patients breathing exercises through short videos could reduce shortness of breath, increase activity, and improve sleep. Sixty adults with COPD followed a 30-day program of pursed-lip and diaphragmatic breathing, guided by a 5-7 minute vid…

This study tested whether using virtual reality (VR) headsets for balance exercises could help people with mild-to-moderate COPD. Fifty participants did VR training three times a week for eight weeks. Researchers measured balance, walking ability, and lung function to see if VR t…

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could improve sleep quality, reduce anxiety, and stabilize vital signs in intensive care patients with COPD. Fifty patients were split into two groups: one received VR sessions for a week, th…

This study tested whether a 3-week home exercise program before lung cancer surgery could help patients recover more quickly. 90 patients with lung cancer and COPD were split into two groups: one received only chest physiotherapy, the other added home exercise training. Researche…

This study tested a triple-combination inhaler (BGF) in 171 adults with moderate-to-severe COPD. Participants received BGF, a dual-combination inhaler (BFF), or placebo in random order. The goal was to see if BGF improves breathing capacity and exercise endurance compared to the …

This Phase 2a study tested an inhaled drug called JKN2304 in 42 adults with moderate-to-severe COPD. Participants received either JKN2304, a placebo, or an active comparator (formoterol) for 14 days. The main goal was to check safety, and researchers also measured changes in lung…

This study tested whether one-on-one training from a nurse could help people with asthma or COPD use their inhalers correctly. One hundred adults who already used inhalers took part. The goal was to see if the training improved their technique, knowledge, and how well they stuck …

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This completed study tested a 6-week self-management program for people with COPD. The program included education, breathing exercises, walking, strength training, and relaxation techniques. Researchers measured quality of life, exercise capacity, and mood in 42 participants aged…

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked…

This study tested a newer, potentially safer nerve block (MTP block) against the standard one (thoracic paravertebral block) for pain after chest surgery. 180 adults having lung surgery through a large chest incision were included. The goal was to see if the newer block provides …

This small study tested whether gentle electrical stimulation of the vagus or trigeminal nerve could ease severe breathlessness in people with advanced COPD. Eight participants tried both active and sham stimulation during exercise. The main goal was to see if such a study is eve…

This study tested a new device called the COMBO Endoscopy Oropharyngeal Airway in 104 adults undergoing a sedated lung procedure (fiberoptic bronchoscopy). The device combines oxygen delivery, airway support, and breathing monitoring into one tool. The goal was to see if it could…

This study tested whether a supplement called GCWB1001 can help adults with mild breathing symptoms like cough, phlegm, and chest tightness. 120 people took either the supplement or a placebo for 12 weeks. The goal was to see if symptoms improved and if it was safe.

This study followed 661 Italian adults with moderate to severe COPD who were prescribed the Trimbow inhaler. Researchers measured changes in health status using the COPD Assessment Test (CAT) and how well patients stuck to their medication over 12 months. The goal was to see if t…

This study tested a new ventilator mode called NAVA for people with chronic obstructive pulmonary disease (COPD) who need a breathing machine. NAVA uses the patient's own diaphragm signals to control the machine, aiming to improve comfort and reduce time on the ventilator. The st…

This study tested whether a digital multimedia education program could help older adults (60+) with COPD better manage their condition. Participants used an e-book on their phones or computers, guided by a nurse, over 8 weeks. The goal was to improve disease knowledge, self-care …

This study looked at two different breathing exercises for people with COPD, a long-term lung disease. 58 adults were split into two groups: one used a device that creates vibrations while breathing out, and the other used a special breathing technique. The goal was to see which …

This small pilot study looked at whether a 12-week tai chi program is practical and helpful for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or usual care. The study focused on whether tai chi could improv…

This study tested whether pursed lip breathing exercises and laughter therapy can reduce shortness of breath, improve health status, and lower care dependence in people with chronic obstructive pulmonary disease (COPD). 63 adults with COPD were split into three groups: one did br…

This study looked at whether playing the harmonica could help people with COPD improve their breathing muscle strength, reduce shortness of breath during activity, and boost quality of life. Fifteen people who had completed a pulmonary rehab program took part in a 12-week harmoni…

This study looked at 200 children aged 2 to 12 with mild to moderate croup, a viral infection that causes a barking cough and breathing trouble. Researchers compared giving the steroid dexamethasone as a pill versus an injection to see which works better for easing symptoms. The …

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study tested whether a respiratory physiotherapy program using PowerBreathe and PEP Therosold devices can improve lung function in elderly patients with chronic obstructive pulmonary disease (COPD). Sixty participants over age 65 were split into two groups to compare differe…

This study tested a forgiveness-based motivational interviewing program in 30 COPD patients. Half received the counseling; the other half did not. Results showed that those who received the program had significantly lower death anxiety and higher life satisfaction and forgiveness…

This study tested whether dexmedetomidine, a sedative, can safely calm agitation in 70 COPD patients with psychosis who were using non-invasive breathing masks. The goal was to see if it could prevent the need for a breathing tube. Researchers measured how many patients needed in…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested whether a gentle movement therapy called Basic Body Awareness Therapy (BBAT) could help people with chronic lung disease (COPD) feel less breathless. 25 participants in Hong Kong took part. The therapy focuses on balance, free breathing, and mental awareness to …

This study tested whether learning self-hypnosis can help people with severe COPD manage anxiety and shortness of breath during pulmonary rehabilitation. 133 participants took part, with some learning hypnosis techniques in two group sessions. The goal was to see if hypnosis coul…

This study tested whether adding laser acupuncture to standard COPD treatment improves lung function and quality of life. Forty adults with stable COPD received either real or sham laser acupuncture sessions. Researchers measured breathing tests and symptom questionnaires after 4…

This study tested a special type of acupuncture, called thread-embedding acupuncture, in 34 adults with stable COPD. Participants received either the real treatment or a sham version, and researchers measured their walking ability, breathlessness, and quality of life over three m…

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested whether giving the breathing drug salbutamol through a high-flow nasal device works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The goal was to see if the new method is not worse at improving lung function.

This study followed 10 people with moderate to severe COPD in Romania who started taking the inhaler TRIXEO AEROSPHERE. Researchers measured changes in their health status and treatment satisfaction over 3 and 6 months. The goal was to see how the medication works in everyday lif…

This study tested if applying cold atmospheric plasma to the gums for one minute before a dental numbing shot reduces pain. Thirty healthy adults received the plasma on one side of the mouth and a standard injection on the other. The goal was to see if the plasma made the injecti…

This Phase 1 trial tested the safety and tolerability of a new drug called 9MW1911 in 48 healthy adults. The drug is being developed for asthma, COPD, and atopic dermatitis. Participants received either the drug or a placebo by IV infusion, and researchers monitored side effects …

This study tested an experimental drug called GDC-6599 in 49 adults with chronic cough that persists despite treatment for asthma, COPD, or for unknown reasons. Participants took the drug or a placebo for two weeks, then switched. The goal was to see if the drug reduces cough fre…

This study looked at whether people with chronic lung disease who experience drops in oxygen during exercise can walk just as far without extra oxygen as with it. Forty patients completed a 6-minute walk test twice: once breathing normal air and once with low-flow oxygen. The goa…

This study tested whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in people with COPD. Twenty adults with stable COPD cycled while researchers measured their breathing discomfort and endurance. The goal was to see if a simple, natural s…

This study tested two methods to strengthen leg muscles in 102 people with severe COPD: electrical stimulation (using pads on the skin) and stationary cycling. Both were part of a 3-4 week hospital rehab program. The goal was to see which better improves leg function and exercise…

This study tested whether adding a special breathing exercise (inspiratory muscle training) to a standard 3-week pulmonary rehab program helps reduce shortness of breath more than rehab alone. It included 38 COPD patients with normal breathing muscle strength. The goal was to see…

This study tested a 6-week coaching program based on the Information-Motivation-Behavioral skills model to help patients with chronic hypercapnic respiratory failure use their home ventilator more consistently. The program included education, motivation, and practical skills trai…

This study tested whether a home-based pulmonary rehabilitation program with health coaching helps people with COPD stay committed to rehab after leaving the hospital. 296 adults aged 40 and older who were hospitalized for a COPD flare-up took part. The home program used remote t…

This pilot study tested a 15-minute controlled breathing routine (REST) in 20 adults with COPD who reported high stress. Participants learned three yoga breathing techniques and practiced them twice daily for a week with remote guidance. The study aimed to see if the routine was …

This completed study tested whether a structured yoga program (including breathing exercises, relaxation, and postures) can improve functional capacity and quality of life in adults aged 30-55 with bronchiectasis. 60 participants were enrolled. The study measured shortness of bre…

This early study tested whether giving mesenchymal stem cells through an IV is safe for people with advanced COPD. Fifteen participants received the treatment, and researchers watched for any immediate side effects. The study did not aim to cure COPD, but to see if this approach …

This study tested whether a health coach can help low-income patients with COPD or asthma get better access to lung specialists and follow their advice. 328 patients from public clinics were randomly assigned to either usual care or a health coach who prepared them for specialist…

This study tested a telephone-based program called EPIC, where nurse coaches guide older adults with COPD and their caregivers through sessions on managing symptoms and planning care. The goal was to see if the program is feasible and acceptable. Fifty participants were split int…

This study tested whether a combination inhaler (Glycopyrrolate/Formoterol) helps people with COPD exercise longer compared to a placebo. 52 participants with stable COPD completed the trial. The main goal was to measure any increase in exercise time on a stationary bike.

This study tested whether a home-based program combining physical and cognitive exercises is feasible for people with COPD. Twenty-four adults aged 50 and older with moderate COPD participated in an 8-week program. The goal was to see if patients could stick with the training and…

This study tested whether a breathing training device (IMT/PEP) could improve lung function and reduce breathlessness in people with severe, exacerbation-prone COPD. 61 stable patients used the device twice daily for 12 weeks alongside their usual medications. Researchers measure…

This study tested whether a mild gas medicine called isoflurane, given through a special device (AnaConDa), helps people with severe COPD flare-ups feel more comfortable during non-invasive ventilation (a breathing mask). Ten adults with COPD and high carbon dioxide levels took p…

This study tested whether a home-based pulmonary rehabilitation programme could help people with COPD in areas with limited healthcare resources. 128 participants either received the 8-week home programme (exercise, education, and phone support) or standard care. Researchers meas…

This small study tested whether a painless brain stimulation technique called tDCS could reduce shortness of breath in people hospitalized with a COPD flare-up. Thirty participants received either real tDCS or a sham version, plus standard physiotherapy, over three days. Research…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study tested a wearable vest called ELECTROVEST that vibrates and gently stimulates muscles to help clear mucus from the lungs. It included 21 adults with COPD, cystic fibrosis, bronchiectasis, or asthma. The vest was compared to a standard chest-vibration device to see if i…

This study tested whether using a hand fan for 10 minutes daily over six weeks could reduce shortness of breath, anxiety, and depression in people with COPD. Fifty-nine patients from a hospital in Turkey took part, with half using the fan and half receiving standard care. The goa…

This study tested whether adding a specific breathing technique called 4-7-8 breathing to standard COPD care can reduce shortness of breath, improve lung function, and boost quality of life. Forty adults with mild to moderate COPD were enrolled. The technique involves breathing i…

This study looked at whether taking oral corticosteroids (prednisone) for 5 days can help people with COPD who are having a flare-up. The trial involved 189 adults aged 40 and older who were treated in general practice. Researchers tracked treatment failure, including emergency v…

This study tested whether a 25% lower dose of dexamethasone (0.15 mg/kg) works as well as the standard dose (0.6 mg/kg) for treating croup in children. Croup is a viral infection that causes airway swelling and breathing trouble. The trial involved 50 children and tracked return …

This study tested two types of exercise programs in 36 people with COPD: one focused on breathing muscles and the other on core (abdominal and back) muscles. The goal was to see which better improves diaphragm function, breathing strength, exercise ability, and quality of life. P…

This phase 3 trial tested whether the drug N-acetylcysteine (NAC) can thin mucus and make it easier to cough up in adults with respiratory infections like bronchitis or bronchiectasis. About 333 hospitalized patients in China received either NAC, another expectorant (ambroxol), o…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at whether chronic lung inflammation from bronchiectasis raises the risk of heart disease and accelerates aging. Researchers will measure heart function, artery stiffness, bone density, muscle mass, and blood markers in 110 adults aged 40 to 80 with confirmed bro…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This study looked at how the nasal immune system of people with COPD reacts to a live flu vaccine (FluMist). Researchers compared those who have frequent COPD flare-ups to those who do not, to see if differences in immune response or viral replication might explain the flare-ups.…

This study looks at how mucus from the airways of people with bronchiectasis affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind to bacteria in the lab. The…

This study looked at 275 adults with a lung condition called bronchiectasis, where airways are stretched and trap mucus, leading to infections. The goal was to learn more about the physical traits, lung scans, and germs in the lungs of people with the unexplained form of the dise…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This completed study surveyed 270 adults with COPD in Turkey to learn about their use of and attitudes toward traditional and complementary medicine practices like herbal remedies, acupuncture, and cupping. Researchers aimed to understand how often patients turn to these methods …

This completed study collected information from 101 patients and healthcare providers to design a care pathway for COPD in people also being treated for lung or head and neck cancer. The goal was to identify common burdens and barriers to COPD care in oncology clinics. The findin…

This study looked at how doing a mental task while standing affects balance in people with chronic lung disease (COPD). Researchers compared 36 adults with COPD to healthy volunteers to see if their balance got worse when they had to think at the same time. The goal was to better…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at whether people with COPD have trouble controlling their knee muscles during everyday tasks that require precise, gentle force. Researchers compared 36 participants (COPD patients and healthy volunteers) as they performed small, controlled leg contractions. Th…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This study looks at fibrocytes—cells involved in scarring—in the lungs and blood of 50 people with COPD compared to healthy controls. Researchers want to understand how these cells contribute to airway remodelling, the abnormal tissue repair that makes COPD worse. The goal is to …

This study looked at whether specific cells from the blood, called fibrocytes, are involved in muscle wasting (sarcopenia) in people with COPD. Researchers compared thigh muscle samples from 22 COPD patients with and without muscle loss. The goal was to understand why muscle loss…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at how people with COPD experience physical activity. Researchers interviewed 54 participants and had them wear activity monitors to compare standard activity levels with personalized intensity measures. The goal was to better understand how to tailor activity r…

This completed observational study included 123 adults with COPD or asthma. Researchers measured breathing muscle strength using a special device and then tried to predict those results from simpler tests like spirometry and body composition. The goal was to see if doctors could …

This study looked at how well people with COPD can learn to use three different inhaler devices: Diskus, Breezhaler, and Respimat. Twenty-four participants were taught to use each device and then checked for mistakes. The goal is to find better ways to train patients so they get …

This study tested whether taking two common blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of smokers with COPD. Fifteen current or former smokers with and without COPD participated. The goal was to see changes on a special CT scan, not…

This study tested whether treating dental implants with cold plasma before placement helps them become more stable early on. Eleven patients each received four implants, each treated with a different plasma method or none at all. The researchers measured implant stability over ei…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study looked at how a new medicine called EP395, being developed for COPD, interacts with other common drugs. It involved 37 healthy adults aged 18 to 55. The goal was to see if EP395 changes how other drugs work in the body, which helps doctors use it safely in the future.

This study looked at how one night of no sleep affects shortness of breath and exercise ability in 20 people with COPD. Participants did exercise tests after a normal night and after a sleepless night to compare. The goal was to understand if sleep loss makes breathing harder dur…

This completed study from Mansoura University looked at how low fat-free mass (muscle) affects the outlook for people with COPD. Researchers studied 90 adults aged 40 and older with confirmed COPD. They used breathing tests, a 6-minute walk test, CT scans, and the BODE index to m…

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers measured lung activity using a special imaging method. The goal was to understand how ma…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study tested whether adding a brief pause at the end of each breath (end-inspiratory pause) during mechanical ventilation could help remove carbon dioxide more efficiently in patients with COPD. Fourteen deeply sedated, intubated adults with COPD were given two 30-minute ven…

This study looked at 80 people who had a lung transplant to see if measuring neural respiratory drive (a breathing signal) and a protein called Pro-BNP could predict when their condition might get worse. The goal is to catch problems like infection or rejection early so treatment…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study explored why some people with COPD lose muscle mass and strength (sarcopenia). Researchers measured exercise ability, frailty, and breathing in 42 adults with COPD. The goal was to find which factors most affect muscle loss, helping guide future care.

This study looked at 37 people with COPD who were having a lung-attack (sudden worsening of breathing). Researchers compared two treatment strategies: using only short-acting rescue inhalers versus adding long-acting inhalers. They used a safe, easy breathing test called oscillom…

This study tested two types of breathing muscle training in 24 people with COPD. One was traditional (using a handheld resistance device while sitting), and the other was functional (integrated into movement). Researchers measured muscle oxygen levels, shortness of breath, and fa…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This study looked at how breathing and swallowing interact in people with severe COPD who were in the hospital for a sudden worsening of their condition. Researchers wanted to see if using a non-invasive breathing machine (NIV) changes this interaction. Sixteen patients were obse…

This study looked at how well people with severe COPD follow their prescribed long-term oxygen therapy. Researchers used a special device on oxygen sources and a connected watch to track daily oxygen use and physical activity. The goal was to give doctors better information betwe…

This study looked at how the lungs move chloride, sodium, and bicarbonate in 42 patients with idiopathic bronchiectasis (widened airways of unknown cause). Researchers measured electrical signals in the airway lining during bronchoscopy and took nasal and bronchial samples. The g…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study tested whether a large language model (like GPT-4) could help doctors follow official treatment guidelines for COPD. 78 hospitalized COPD patients were randomly assigned to either receive standard care or have their discharge treatment reviewed by the AI. The goal was …

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This study looked at how over 1,600 people's bodies react to different breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. Researchers measured blood sugar, fats, and other markers after meals to understand why responses vary. The goal is to pave the way fo…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This study looked at how itepekimab, an experimental drug, affects airway inflammation in 49 adults aged 40-70 with COPD who smoke or used to smoke. Participants stayed on their usual COPD medications while receiving itepekimab for 12 weeks. The goal was to understand the drug's …

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This early-stage study tested a single dose of an inhaled drug called DBM-1152A in 44 healthy Chinese adults. The main goal was to see if the drug is safe and how the body processes it. No treatment was given for any disease; the study simply gathered safety information to guide …

This early-phase trial tested the safety and tolerability of an inhaled drug called DBM-1152A in 20 healthy Chinese adults. Participants received either the drug or a placebo once daily for 7 days at different dose levels. The study focused on side effects and how the drug moves …

This study looked at how nutritional supplements affect energy use in people with chronic lung disease who are already in a pulmonary rehab program. Researchers measured resting energy needs in 35 adults aged 45-80. The goal was to better understand how to support their recovery …

This study looked at 8 people with a FLNA gene mutation to see how many also had emphysema, a lung condition that damages air sacs. Participants had a chest scan, breathing tests, and a checkup with a lung doctor. The goal was to confirm if this rare genetic change is linked to u…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with the medication BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to understand real-world outco…

This study tested a decision support program for people with advanced COPD and their family members. The goal was to help them feel more confident and less conflicted about end-of-life care choices. 226 patients and their families took part, and researchers measured how the progr…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This pilot study tested whether it is possible to collect and analyze small RNA molecules from a person's breath. Researchers took breath samples from 25 volunteers (healthy people and a few with lung disease) at rest and after intense exercise. They successfully extracted and se…

This study looked at whether three different devices (Accuhaler tester, Ellipta tester, and Turbutester) can accurately measure how hard people with COPD can inhale. 82 adults with COPD used the testers, and their results were compared to a standard device. The goal was to see if…

This study tested whether CT scans can better measure bone health and predict fracture risk in 560 smokers with and without COPD. Researchers used CT images of the spine and ankle to assess bone structure, alongside standard bone density tests. The goal is to create a more accura…

This completed study from Fudan University looked at 200 older adults with COPD who also have sarcopenic obesity — a condition where muscle loss and excess fat occur together. Researchers used a device called InBody S10 to measure body composition and phase angles, aiming to buil…

This study tested a new way to find early signs of lung damage in people with COPD or ILD by analyzing carbon dioxide (CO2) in their breath in real time. Researchers aimed to detect changes before standard lung function tests show any problems. The study included 40 adults, inclu…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at whether short bursts of exercise (interval training) help keep oxygen levels higher in people with COPD who experience drops in oxygen during activity. Twelve patients completed both an interval and a continuous exercise session while their oxygen levels were…

This study looked at 150 adults with COPD to see if a drop in exercise ability during pulmonary rehabilitation could predict when a flare-up (exacerbation) might happen. Researchers tracked changes in physical performance and compared them to hospital visits for COPD attacks. The…

This study looks at whether low vitamin D levels in early pregnancy are linked to breathing problems in children ages 5 to 6. Researchers measured airway resistance in 142 children whose mothers had vitamin D levels checked during the first trimester. The goal is to understand if…

This study tested whether a wearable device (Vivalink) could track health signs like heart rate, breathing, and activity in people with COPD. 77 participants wore the device for 3 months to see if the data could predict when symptoms would get worse. The goal was to find a way to…

This study looked at medical records of over 21,000 adults with type 2 diabetes and COPD to see if a diabetes drug called SGLT2 inhibitor lowers the chance of getting lung cancer compared to an older drug, sulfonylurea. Researchers did not give anyone new medicine; they just anal…

This study interviewed 26 older adults (75+) with chronic illnesses who take many medications. Researchers wanted to understand how patients feel about being cared for by the same doctor over time, and what happens when they lose that regular doctor. The goal was to learn about t…

This completed study looked at 170 smokers with COPD to understand how lung damage affects brain structure and thinking skills. Participants took memory and thinking tests, had lung function tests, and underwent brain scans. The goal was to find early clues that could one day lea…

This completed study looked at whether an online tool called the COPD Optimiser could help general practitioners find ways to improve care for people with COPD. Researchers enrolled 100 patients in the Netherlands and used the tool during a regular check-up to see where treatment…

This study looked at how the heart and lungs of 10 people with moderate COPD respond to a 30-minute exercise test with short, intense work periods. Researchers measured blood pressure in the lungs and overall heart function. They found that lung blood pressure did not spike dange…

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This study followed 216 people with COPD and other health conditions for up to 38 months. Participants used a mobile app to log daily symptoms and other health data. The goal was to find patterns that could predict when a person might have a flare-up or get worse, so doctors can …

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This study looked at 65 people with COPD to see if a simple six-minute stepper test can give similar information as a standard, more complex exercise test. The goal is to make it easier for patients to get assessed for pulmonary rehabilitation, especially in places where the stan…

This completed study looked at whether people with COPD have abnormal leakage in their lung capillaries during exercise, which could contribute to shortness of breath. Researchers compared 32 participants (COPD patients and healthy controls) by measuring lung permeability before …

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study followed 96 adults with asthma or COPD in Mersin, Türkiye, to see how extreme heat waves and air pollution impact their lung health. Researchers measured lung function, airway inflammation, symptoms, and quality of life during normal weather and again during heat waves…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study observed 100 people with COPD who were sedated for a stomach and colon exam. Researchers wanted to see if certain risk factors, like symptom severity or past hospital stays, could predict breathing problems during the procedure. They also tested a new monitor called th…

This study looked at 2000 adults with bronchiectasis, a long-term lung condition. Researchers combined CT scan details, lung bacteria information, and patient history to see if they could better predict how the disease would progress. The goal was to find new ways to understand a…

This study looks at whether the six-minute stepper test can reliably measure changes in exercise tolerance during a 3-week pulmonary rehabilitation program for people with COPD. Researchers will compare results from the stepper test with the standard six-minute walk test. The goa…

This study tested how a single session of one-leg cycling affects blood vessels and muscles in 26 people with COPD. The goal was to see if this type of exercise could improve oxygen use and artery health. The results may help design better exercise programs for COPD patients.

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study measured breathing patterns in 163 adults with asthma or COPD to help computers predict how much of an inhaled drug actually reaches the lungs. Researchers used these real-world breathing measurements to improve simulations of aerosol drug deposition. The goal is to ma…

This study looked at 70 premature babies in the NICU to see if levels of certain proteins called neurotrophins in their blood could predict later lung and brain development. Researchers measured these proteins, which help nerves grow and lungs work properly, and tracked the babie…

This study tested a new self-administered questionnaire called DYSLIM to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, cystic fibrosis, and pulmonary hypertension. Researchers enrolled 199 participants to check if …

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This completed study used chest MRI scans to look at blood flow in the lungs of 30 people with COPD. The goal was to learn how blood vessels adapt during exercise and how this relates to disease progression. By better understanding these changes, researchers hope to improve care …

This study looked at 100 people with advanced COPD to see if the fungus aspergillus in their sputum is linked to their quality of life and symptoms. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 and 3 months, and in p…

This study tested whether a questionnaire called VQ11 can accurately measure changes in quality of life for people with COPD who start taking a long-acting bronchodilator. Fifty-seven stable COPD patients filled out the VQ11 before and after three months of treatment. The goal wa…

This early-stage study tested a new drug called AZD6793 in 93 people to see if it is safe and how the body processes it. The study included healthy volunteers and people with moderate to severe COPD. The main goal was to check for side effects and measure drug levels in the blood…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The study was comple…

This study looked at how breathing through a facemask-like resistance affects exercise in people with chronic obstructive pulmonary disease (COPD). 52 volunteers walked on a treadmill with and without added resistance to measure shortness of breath and effort. The goal was to und…

This study followed 31 adults with COPD for 12 weeks to track how their inflammation levels, lung function, and symptoms change over time. Researchers measured daily lung function and symptoms, along with weekly or biweekly blood and sputum tests. The goal was to better understan…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …

This study tested whether a special essential amino acid supplement (high in leucine) could help elderly patients with COPD build muscle protein better than a standard amino acid mixture. Thirty-four participants received a one-time dose of either supplement, and researchers meas…

This study looked at how the body handles short-chain fatty acids (SCFAs) in people with COPD compared to healthy adults. Researchers measured SCFA metabolism and body composition in 63 participants. The goal was to understand if SCFA production is lower in COPD, which could affe…

This study tested whether a fiber supplement called inulin changes how the body processes certain fatty acids in people with chronic obstructive pulmonary disease (COPD). Researchers compared 87 participants, including COPD patients and healthy older and younger adults, over 7 da…

This study reviewed medical records of 59 adults with COPD to see if a standard pulmonary rehabilitation program is safe and effective for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how much walking distance improved in peo…

This study looked at how people with chronic heart failure or COPD process protein from meals. Researchers measured muscle building, body composition, and gut function in 90 adults aged 45 and older. The goal was to understand why muscle loss happens and how to design better diet…

This study looked at whether adding a mental task (like counting or word games) to standard exercise helps people with COPD improve their physical and mental abilities. 42 participants were split into two groups: one did standard pulmonary rehab, the other added cognitive tasks d…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study tested whether a quick, non-invasive breathing test called impulse oscillometry (IOS) can track lung function during COPD exacerbations and recovery. 38 patients were tested during a flare-up and again 6-12 weeks later. The results suggest IOS can detect changes in sma…

This study looked at whether doing two 6-minute walk tests at the end of a pulmonary rehabilitation program gives a more accurate measure of exercise capacity in people with COPD. Researchers compared the distance walked in the first and second tests to see if there was a meaning…

This study tested two different ways of using a breathing machine at night to help people with COPD get off the machine faster. Nineteen patients were randomly assigned to one of two ventilation modes during sleep. Researchers measured how long it took to wean off the ventilator …

This completed Phase 1 study in 30 healthy volunteers looked at how cyclosporine, a drug that blocks certain transporters, affects the amount of CHF6001 (Tanimilast) in the blood. Participants took CHF6001 alone first, then again after taking cyclosporine. The goal was to see if …

This study followed 60 people who survived a severe breathing crisis in the ICU. Researchers wanted to learn about their health, sleep disorders, and why some need to return to the hospital. Participants had sleep tests three months after leaving the ICU and were tracked for a ye…

This study tested whether a telerehabilitation system can reliably track heart rate, oxygen levels, and step counts in people with chronic obstructive pulmonary disease (COPD). In the first phase, 40 patients used the system during exercise sessions; in the second phase, they use…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This study tested whether a special type of CT scan (dual-energy CT) can provide useful information for planning lung valve placement in people with emphysema. Researchers enrolled 13 adults who were already scheduled for the valve procedure. The goal was to see if the scan could…