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Simple breathing pause may help clear CO2 in COPD patients on ventilators

NCT ID NCT07207967

Completed Knowledge-focused Sponsor: Sanatorio Anchorena San Martin Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a brief pause at the end of each breath (end-inspiratory pause) during mechanical ventilation could help remove carbon dioxide more efficiently in patients with COPD. Fourteen deeply sedated, intubated adults with COPD were given two 30-minute ventilation patterns—one with the pause and one without. The researchers measured blood gases and lung mechanics to see if the pause improved CO2 clearance without causing lung overinflation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
end-inspiratory pause (a breathing pattern adjustment during mechanical ventilation)
What this could lead to
If this approach works, it could help doctors ventilate COPD patients more efficiently, potentially reducing the risk of complications from high carbon dioxide levels.
What could go wrong
This was a very small, short-term study (14 patients, 30-minute test periods). Results may not apply to all COPD patients or to longer-term ventilation. The technique could still cause lung overinflation in some cases.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset Positive-Pressure Respiration, Intrinsic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE)

Contacts and locations

Locations

  • Sanatorio Anchorena San Martín

    San Martín, Buenos Aires, B1650, Argentina

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