Tracheal stenosis

This study tests a special balloon coated with the drug paclitaxel to treat benign (non-cancerous) narrowing of the windpipe or main breathing tubes. The balloon is inflated to open the airway, and the drug may help keep it open longer. About 200 adults with this condition will b…

This study tests whether using cryopreserved aortic patches (donated tissue) can safely repair defects in the windpipe or bronchial tubes. Ten people with severe tracheal narrowing or deformities will receive this surgical patch. The main goal is to see if it reduces death and co…

This pilot study tests whether adding a liquid nitrogen cryospray to standard treatments (balloon dilation or laser incision) can prevent benign airway stenosis from coming back within 6 months. About 12 adults with significant tracheal narrowing will receive the cryospray during…

This study compares two surgical methods to fix a narrowed windpipe (tracheal stenosis) caused by injury or long-term breathing tube use. About 30 patients will receive either a slide tracheoplasty or a tracheal resection. The goal is to see which procedure has a higher success r…

This study tests custom-made 3D-printed stents for people with narrowed airways. The stents are designed to fit each person's unique airway shape, which may reduce serious complications like stent movement or blockage. About 30 adults with severe symptoms will receive the stent a…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study compares two ways of helping patients breathe during a procedure to widen narrowed airways. Forty adults will receive either flow-controlled or volume-controlled ventilation. Researchers will measure oxygen levels and airway pressures to see which method is safer and m…

This study observes oxygen levels in the airway during rigid bronchoscopy, a procedure to treat blocked airways. Researchers will measure how long it takes for oxygen to drop to a safe level when using a special ventilator mode. The goal is to reduce the risk of airway fires duri…

This study examines discarded tissue from 10 patients with benign tracheal stenosis, a rare condition where scarring narrows the airway. Researchers will analyze the tissue's RNA to identify inflammation and fibrosis patterns. The goal is to better understand the disease's molecu…