Which drug keeps COPD patients out of the hospital?

NCT ID NCT04069312

Completed Prevention Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tested two medications, roflumilast and azithromycin, in over 1,000 people with severe COPD and chronic bronchitis. The goal was to see which drug better prevents hospitalizations or death. Participants were current or former smokers aged 40 or older who had been hospitalized for a COPD flare-up in the past year.

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Conditions

The condition(s) this trial relates to.

chronic bronchitis chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC BRONCHITIS CHRONIC OBSTRUCTIVE PULMONARY DISEASE SEVERE

Contacts and locations

Locations

Baylor Scott & White (BSW) Health-North

Dallas, Texas, 75246, United States
Baystate Health

Springfield, Massachusetts, 01199, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke

Durham, North Carolina, 27705, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Johns Hopkins University

Baltimore, Maryland, 21224, United States
Kaiser Permanente

Portland, Oregon, 97227, United States
Lenox Hill/Northern Westchester Hospital (Northwell Health)

Mount Kisco, New York, 10549, United States
Mount Sinai

New York, New York, 10029, United States
NorthShore Hospital

Glenview, Illinois, 60026, United States
Northwestern

Chicago, Illinois, 60611, United States
Ochsner Medical Center

New Orleans, Louisiana, 70121, United States
Ohio State University

Columbus, Ohio, 43210, United States
Providence Health and Services

Spokane, Washington, 99204, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama

Birmingham, Alabama, 35233, United States
University of Arizona

Tucson, Arizona, 85734, United States
University of California, Davis Health

Sacramento, California, 95817, United States
University of Illinois Chicago

Chicago, Illinois, 60612, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas

Kansas City, Kansas, 66160, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Missouri, Kansas City

Kansas City, Missouri, 64108, United States
University of North Carolina, School of Medicine

Chapel Hill, North Carolina, 27599, United States
University of Pittsburg Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Vermont

Burlington, Vermont, 05401, United States

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