New pill could quiet chronic cough in adults
NCT ID NCT05660850
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an experimental drug called GDC-6599 in 49 adults with chronic cough that persists despite treatment for asthma, COPD, or for unknown reasons. Participants took the drug or a placebo for two weeks, then switched. The goal was to see if the drug reduces cough frequency and severity. Results are not yet available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GDC-6599 (an experimental oral drug)
- What this could lead to
- If successful, this could lead to a new treatment option for people with chronic cough that doesn't respond to other therapies.
- What could go wrong
- This is a small, early-phase trial with only 49 participants. The drug may not work better than placebo, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHRONIC REFRACTORY COUGH (CRC) WITH NON-ATOPIC ASTHMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
ADAC Research PA
Greenville, South Carolina, 29607, United States
-
Belfast City Hospital
Belfast, BT9 7AB, United Kingdom
-
Bellingham Asthma, Allergy & Immunology
Bellingham, Washington, 98225, United States
-
California Medical Research Associates, Inc.
Northridge, California, 91324, United States
-
Castle Hill Hospital
Cottingham, North Humberside, HU16 5JQ, United Kingdom
-
Clinical Research Associates Of Central Pa , Llc
DuBois, Pennsylvania, 15801-2277, United States
-
Diex Recherche - Québec - HyperCore - PPDS
Québec, Canada
-
Glenfield Hospital
Leicester, LE3 9QP, United Kingdom
-
Kings College Hospital
London, SE5 9RS, United Kingdom
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
-
McMaster University Medical Centre
Hamilton, Ontario, L8N 3Z5, Canada
-
Pharmaceutical Research & Consulting, Inc.
Dallas, Texas, 75231, United States
-
Pioneer Clinical Studies
Coral Gables, Florida, 33134, United States
-
Queen Anne Street Medical Centre
London, W1G 8HU, United Kingdom
-
Royal Infirmary of Edinburgh
Edinburgh, EH16 4SA, United Kingdom
-
Southern California Institute For Respiratory
Los Angeles, California, 90048, United States
-
TrialsWest Pty Ltd
Spearwood, Western Australia, 6163, Australia
-
West Walk Surgery
Bristol, BS37 4AX, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.