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Can a simple blood test catch lung cancer earlier in smokers with COPD?

NCT ID NCT02500693

Completed Diagnosis Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk: smokers and ex-smokers with COPD. Researchers combined this blood test with low-dose CT scans over three yearly screenings in 683 participants. The goal was to see if CTCs could reduce false positives and catch cancers that CT scans might miss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Isolation of circulating tumor cells (CTC) from blood
What this could lead to
If successful, this approach could improve early lung cancer detection in high-risk COPD patients, reducing false positives and missed cancers from CT scans alone.
What could go wrong
This is a completed observational study, not a treatment trial. The CTC test may not prove reliable enough for routine screening, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset lung neoplasm lung cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG NEOPLASMS PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

Contacts and locations

Locations

  • CH de Roubaix

    Roubaix, France

  • CHRU de Lille

    Lille, France

  • CHU d'Amiens

    Amiens, France

  • CHU de Dijon

    Dijon, France

  • CHU de Grenoble

    Grenoble, France

  • CHU de Montpellier

    Montpellier, France

  • CHU de Nancy

    Nancy, France

  • CHU de Reims

    Reims, France

  • CHU de Rennes

    Rennes, France

  • CHU de Rouen

    Rouen, France

  • CHU de Saint Etienne

    Saint-Etienne, France

  • CHU de Strasbourg

    Strasbourg, France

  • CHU de Toulouse

    Toulouse, France

  • CHU de Tours

    Tours, France

  • Hospices Civils de Lyon

    Lyon, France

  • Hôpital Bichat

    Paris, France

  • Hôpital Cochin

    Paris, France

  • Hôpital Européen Georges Pompidou

    Paris, France

  • Hôpital Nord

    Marseille, France

  • Hôpital TENON

    Paris, France

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