Can mucinex ease chronic bronchitis? new study investigates
NCT ID NCT05843669
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested how well the over-the-counter medication Mucinex works for people with stable chronic bronchitis when used over 12 weeks. 82 adults aged 40 and older took part, tracking their symptoms, satisfaction, and any side effects. The goal was to see if long-term use helps manage cough and mucus production in daily life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
82 people
The number who actually took part.
- Started
-
Jul 2023
- Finished
-
Nov 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 90 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients with a diagnosis of SCB at recruitment, male and female, over 40 years of age * A Pulmonary Function Test with FEV1/FVC less than 0.7 (70%) at the time of enrollment or at least a 10 year history of cigarette abuse. * Patients who have chronic sputum production 3 months out of the year for 2 consecutive years and a productive cough as part of their symptoms. * Patients who understand and are able to fill out a questionnaire and ePRO weekly * Patients who have not used guaifenesin containing products within one month of the time of study enrollment * Patients with 6 to 12 (ideally 12)-month historical data - retrieved from either electronic medical records (EMR), electronic health records (EHRs), or provided by the patient via interview. Rescue medicine: • No rescue medicine will be provided. Information regarding concurrent rescue medications, either OTC or via prescription, will be collected. Exclusion Criteria: * Patients who are pregnant or breastfeeding * Participation in another study involving an investigational product within 30 days of the baseline visit * Pulmonary diagnosis other than CB, (such as cystic fibrosis, alpha-1 antitrypsin deficiency, bronchiectasis, or pulmonary fibrosis) * Active lung cancer or history of lung cancer if it has been less than 2 years since lung resection or other treatment including chemotherapy or radiation. If the patient has a history of lung cancer, they must be in remission * Psychiatric disorder that precludes participation in the study * History of alcohol and/or drug abuse within one year of study start * Patients taking intermittent antibiotics and patients taking oral and systemic corticosteroids (e.g., prednisone at a dose of \> 10 mg/day). * Patients on a chronic stable dose of macrolide antibiotics at the start of the study may be included at the discretion of the Principal Investigator. * Patients who had an acute exacerbation of chronic bronchitis within a period of one month of starting the study that required systematic steroids or antibiotics * Hypersensitivity to guaifenesin, or any other excipient listed in the product.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Chronic bronchitis are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
American Health Research
Charlotte, North Carolina, 28277, United States
-
Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could heat pulses in the airways quiet a Smoker's cough?
- Can a steady drip of local anesthetic speed recovery after open-heart surgery?
- Could stem cells help breathe easier? new trial tests PROCHYMAL for COPD
- Freezing lung lining again? small study tests repeat cryospray safety in COPD
- New supplement tested for cough and phlegm relief
- Massive COPD study aims to unlock secrets of lung disease