Could heat pulses in the airways quiet a Smoker's cough?

NCT ID NCT05641207

Completed Symptom relief Sponsor: Energenx Medical LTD. Source: ClinicalTrials.gov ↗

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests a device called RheOx that delivers controlled heat pulses to the airways to reduce excess mucus-producing cells, which are a hallmark of chronic bronchitis. The study enrolls adults aged 35 to 80 with moderate-to-severe COPD and chronic bronchitis symptoms. Participants receive two treatment sessions, one for each lung, about a month apart. The goal is to see if this procedure can improve symptoms like cough and mucus, as measured by standard questionnaires over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RheOx bronchial rheoplasty system (a device that delivers controlled heat pulses to the airways to reduce mucus-producing cells)
What this could lead to: If it works, this could offer a new way to ease chronic cough and mucus in COPD patients who have chronic bronchitis, improving their daily breathing and quality of life.
What could go wrong: This is an early, small study (40 people) without a comparison group, so results may not be conclusive. The procedure involves two sessions of airway treatment, which carries risks like temporary worsening of symptoms or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHRONIC BRONCHITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic bronchitis chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC BRONCHITIS CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Contacts and locations

Locations

First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
Peking University First Hospital

Beijing, Beijing Municipality, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Hanzhou, Zhejiang, China
The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China
The Tenth People's Hospital of Shanghai

Shanghai, Shanghai Municipality, China
Xiangya Hospital of Central South University

Changsha, Hunan, China
Xinqiao Hospital, Army Medical University

Chongqing, Chongqing Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.