Could a transplant drug keep a rare airway disease at bay?
NCT ID NCT05153668
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested whether the immunosuppressant drug everolimus could help people with idiopathic subglottic stenosis, a rare condition where scarring narrows the airway. Eight participants took everolimus for 42 days after a dilation surgery to open the airway. The goal was to see if the drug could lengthen the time between repeat surgeries, which are often needed to keep the airway open.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Everolimus (an immunosuppressant drug)
What this could lead to
If successful, this could lead to the first FDA-approved drug treatment for idiopathic subglottic stenosis, potentially reducing the need for repeat surgeries.
What could go wrong
This is a very early, small proof-of-concept study with only 8 participants. The drug is an immunosuppressant, which carries risks like infection, and it may not prove effective in larger trials.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Johns Hopkins Outpatient Center
Baltimore, Maryland, 21287, United States