Injury

This trial tests a new approach to face transplantation that aims to reduce the need for lifelong, high-dose immunosuppressive drugs. The method combines a bone marrow cell infusion with a single low-dose immunosuppressant, potentially lowering the risk of infection, cancer, and …

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing furth…

This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children w…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

This study is testing a device called the TrueLok Elevate that uses a technique called transverse bone transport to help heal chronic lower limb ulcers. The device is attached to the leg and slowly moves a piece of bone to stimulate blood flow and tissue healing. Researchers will…

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This study is testing whether cooling the body to 33°C (just below normal) for 48 hours soon after a cervical spinal cord injury can improve nerve recovery and function. Researchers will enroll 120 adults aged 18-70 with severe but non-penetrating injuries. The cooling is deliver…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This trial tests whether a specialized physical therapy technique called blood flow restriction training (BFRT) can improve recovery in people who have experienced a patellar dislocation (kneecap slipping out of place). Participants will undergo 8 weeks of either BFRT or a sham v…

This trial tests whether adding legal support to standard violence recovery care can lower stress and reduce repeat firearm injuries. People treated for violent injuries at a trauma center receive either standard support or additional help with legal issues like benefits and hous…

This trial compares a new biodegradable wound dressing, SupraSDRM®, to standard care for full-thickness wounds—such as severe burns, surgical wounds, or traumatic injuries—that are not ready for immediate skin grafting. The goal is to see if SupraSDRM® helps wounds heal faster an…

This trial asks whether giving severely injured patients whole blood (Low-Titer Group O) is better than giving them separate blood components (red cells, plasma, platelets, and cryoprecipitate) during emergency transfusions. It enrolls about 1,100 adults with major traumatic blee…

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This trial investigates whether a robotic system can improve the accuracy of bone realignment and fixation in orthopaedic trauma surgery. Adults with fractures will receive surgery assisted by the R-Universal® robot, which uses 3D navigation to guide precise movements. The goal i…

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This study tests whether using a person's own fat, combined with a skin graft, can improve tight scars from burns or injury better than standard skin grafting alone. Forty adults with scar contracture will receive either the new fat-plus-skin method or the usual full-thickness sk…

This trial compares two ways to manage the wound after surgical removal of a chronic pilonidal sinus. Half of the 200 participants will receive a negative pressure wound therapy (NPWT) dressing that applies gentle suction to the wound, while the other half will receive standard o…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This trial investigates whether a single-use negative pressure wound therapy (NPWT) device, which applies gentle suction to the closed incision, can reduce surgical site infections, wound complications, and improve scar appearance compared to standard dressings after major lower …

This trial investigates whether two special wound dressings—one made from donated amniotic membrane and another from a synthetic material—can help heal diabetic foot ulcers and venous leg ulcers that have not responded to standard care. Adults aged 18 and older with these hard-to…

This Phase 3 trial investigates whether a psychedelic drug, psilocybin, combined with a specialized trauma-focused therapy (SIRT), can improve depression and anxiety in people with trauma-related major depressive disorder. The study also looks at changes in gut-brain axis biomark…

This study investigates penile transplantation as a way to replace a severely damaged or missing penis with a donor organ, aiming to restore appearance, sensation, and sexual function. It includes men aged 18-69 who have lost their penis due to trauma, surgery, or birth defects. …

This study is looking at how well the Zimmer Nexel Total Elbow works for people who need elbow replacement surgery. It includes 134 adults with conditions like severe arthritis, fractures, or joint instability. The main goal is to see how long the implant lasts and if it is safe.

This study tests whether a drug called interferon gamma can help intensive care patients recover more quickly from pneumonia they got while on a breathing machine. The drug aims to boost the immune system, which is often weakened after severe illness or injury. About 132 adults w…

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This early study tests a new implantable sensor array, called Phantom X, that picks up muscle signals to control a bionic arm. Ten adults with below-elbow amputations will receive the implant and be followed for up to 21 weeks. The goal is to see if the device is safe and allows …

This study tests a wound covering made from donated human placental tissue, called NeoThelium FT, for people with chronic open wounds that have not healed for at least 4 weeks. About 132 adults will receive either standard wound care alone or standard care plus NeoThelium FT. The…

This study tests whether using cryopreserved aortic patches (donated tissue) can safely repair defects in the windpipe or bronchial tubes. Ten people with severe tracheal narrowing or deformities will receive this surgical patch. The main goal is to see if it reduces death and co…

This study tests whether injecting a person's own skin cells from the palm or sole into their amputation stump can thicken the skin and reduce breakdown. Researchers will enroll 50 adults with below-knee amputations who use a prosthetic. The goal is to see if this treatment is sa…

This registry is following 240 people who receive the GORE VIABAHN VBX stent graft to treat blocked or damaged arteries in the abdomen, pelvis, or limbs. Researchers are tracking how well the device works and any serious side effects over time. The goal is to see if the stent gra…

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, inst…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This study tests a bone substitute called Mg OSTEOCRETE in 10 adults with bone defects from tumor removal, loose orthopedic hardware, or trauma. The main goal is to measure how long it takes for the bone to heal after treatment. Researchers will also track patient-reported outcom…

This study tests a special wound dressing made from sheep stomach lining, used with a vacuum device, to see if it helps cover exposed bone or tendon faster than the vacuum device alone. About 30 adults with soft tissue wounds on an arm or leg will take part. The goal is to see if…

This study looks at whether giving a blood thinner called heparin through a vein can improve the chances that a reattached finger will survive after a traumatic amputation. About 188 adults who have had finger reattachment surgery will be split into two groups: one gets heparin, …

This study is testing whether a custom energy-storing leg brace, combined with a high-intensity rehabilitation program, can improve walking, stair climbing, and daily function in people with lower leg injuries. About 370 adults who have been fitted with the brace will be followed…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can help second-degree burns heal faster. Researchers will give the drug or a placebo to 200 adults with fresh burns and track healing rate and scarring. The goal is to see if this safe, e…

This study tests a wireless, bioelectric bandage called PowerHeal™ on infected wounds. Researchers want to see if it clears infection and helps wounds close better than standard care. About 150 adults with infected traumatic wounds will take part. The bandage is changed regularly…

This study is testing whether temporary electrodes placed on nerves in the arm can help people with hand amputations control a prosthetic hand more naturally and feel sensations like touch and movement. Twenty-five adults with hand, forearm, or arm amputations will have the elect…

This study tests whether a special vacuum dressing placed on the surgical wound can reduce complications like infection and re-operation in people with soft-tissue sarcoma of the leg who had radiation before surgery. About 291 adults will be randomly assigned to get either the va…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study tests whether a daily injection of BPC 157, a synthetic peptide, can help people with a moderate hamstring tear heal faster. 120 adults aged 18-45 with a recent MRI-confirmed grade II strain will receive either BPC 157 or a placebo for 14 days, plus standard rehab. The…

This study tests a new device called MIRA, which is implanted under the skin to pick up electrical signals from muscles in the arm. These signals are then used to control a robotic prosthetic hand. The trial involves 5 adults with a below-elbow amputation who will use the device …

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study tests a hospital-based program called Houston-HVIP for people aged 16-35 who have been shot in community violence. Participants get a case manager who helps with needs like job training, housing, and mental health support. The goal is to see if this support reduces the…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether a real-time lung imaging tool called electrical impedance tomography (EIT) can help doctors choose the best ventilator pressure for patients with lung injury after severe trauma or major surgery. The trial will compare EIT-guided pressure settings to the …

This study tests whether OROXID®, a mouthwash that releases oxygen bubbles, can help gums heal better after wisdom tooth removal or similar surgery. Sixty adults will use the mouthwash or standard care for 14 days. Researchers will check for signs like redness, swelling, and woun…

This study tests whether giving antibiotics before burn surgery lowers the chance of infections after the operation. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics before surgery, and half will get a placebo. The goal is to …

This study tests whether a semi-occlusive dressing (a special film changed weekly) works better than surgery for treating single fingertip amputations in adults. About 252 participants will be randomly assigned to either dressing or standard surgery. The main goal is to see which…

This trial tests a device called ResQFoam, an expandable foam injected into the abdomen to stop severe internal bleeding caused by trauma. The study involves 40 people with life-threatening hemorrhagic shock who need emergency surgery. The goal is to see if the foam can safely ra…

This study tests a program called RETAIN that helps people who are injured or ill stay at work or return to work. The program assigns a case manager to coordinate care and connect workers with job support services. About 1,000 adults in Minnesota who are employed or recently unem…

This study tests whether a special tri-layer amnion graft or a single-layer amnion graft can help heal diabetic foot ulcers and venous leg ulcers that have not improved with standard care. About 165 adults with wounds between 2 and 25 cm² that have been open for over 4 weeks will…

This Phase 3 study tests whether a gel called ENERGI-F703 can help close diabetic foot ulcers better than a placebo gel. About 230 adults with diabetes and a foot ulcer that hasn't healed for at least 4 weeks will receive either the active gel or a placebo, along with standard wo…

This study compares surgery (arthroscopic stabilization) to non-surgical care for people who have dislocated their shoulder for the first time. Researchers will track 100 participants aged 14 to 40 over two years to see which approach leads to fewer repeat dislocations and better…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This study tests whether adding live microalgae to a standard skin-regeneration scaffold helps deep wounds heal faster and with fewer infections. Twenty adults with full-thickness skin wounds will receive both the standard scaffold and the algae-enhanced version on different part…

This study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury. 120 children aged 1 month to 18 years will either receive up to 80 rectal ozone sessions plus standard rehab, or rehab alone. The main goal is to …

Researchers at a Baghdad hospital are comparing four trauma severity scoring systems, ISS, NISS, RTS, and TRISS, to see which one best predicts whether an injured patient will die in the hospital. The study follows 150 trauma patients admitted to the emergency department, calcula…

This study tests whether a bedside ultrasound (called FAST) can safely reduce the number of CT scans in children who have suffered a blunt injury to the belly. About 4,300 children will be randomly assigned to get either the FAST exam or standard care without it. The goal is to s…

This pilot study tests a new device called WounDx that gives surgeons information about a wound to help them decide when it's ready to be surgically closed. The study will enroll 40 people with large extremity wounds. The goal is to see if the device can be used smoothly in a hos…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

This study looks at whether a special ultrasound (CEUS) can find hidden bleeding pockets (pseudoaneurysms) in the liver, spleen, or kidneys after an injury, just as well as the standard CT scan. About 385 adults with abdominal trauma will be followed over time with both tests. If…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This study tests whether a special dye called ICG, used with a new imaging device, can help surgeons see how healthy a patient's bone is during surgery. Ten adults with open fractures or bone infections will receive the dye and be imaged. The goal is to see if this technique can …

This study tests a blue dye called Bludigo™ to help surgeons see if the tubes from the kidneys to the bladder (ureters) are open during surgery. About 116 adults having certain surgeries will get either a smaller or larger dose of the dye. The goal is to see which dose works bett…

This study tests a blue dye called Bludigo to help surgeons see if the tubes from the kidneys to the bladder (ureters) are open during surgery. About 48 adults with different levels of kidney function will receive either the dye or a saltwater placebo. The goal is to see if the d…

This study looks at whether a special ultrasound with contrast dye can find internal belly injuries in children after a hard hit or fall, just as well as a CT scan. CT scans use radiation and require moving the child, while this ultrasound can be done at the bedside with no radia…

This trial tests whether giving an inhaled medication called dornase alfa to severely injured patients on breathing machines can lower their risk of developing acute respiratory distress syndrome (ARDS), a serious lung condition. The drug is thought to break down DNA fragments re…

This trial tests whether altering sex hormone levels can make muscles, tendons, and bones more resilient to the physical and mental stress of military-style training. Healthy adults aged 18-40 will undergo a 4-week training program, with some receiving goserelin to suppress hormo…

This study tests if teaching people how to use mobility devices like crutches or walkers before foot or ankle surgery can lower their risk of falling after the operation. About 250 adults having elective foot or ankle surgery will take part. The goal is to see if this simple trai…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study tests a community violence prevention program for adults who have been hospitalized with a gunshot wound in Central Arkansas. The program offers bedside support, peer mentoring, and case management to help people stay safe and address mental health needs. Researchers w…

This study tests an online program called Store Safely that teaches rural families with children how to store firearms more safely. The program includes videos, facts, and a personalized action plan. Researchers will check if families lock up more guns after using the program. 60…

This study tests whether a brief counseling program called BeSMART, given to parents while their child is in the hospital, can improve how they store firearms at home. About 400 caregivers of hospitalized children will be randomly assigned to receive the counseling or usual care.…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests a community-driven program to reduce gun violence in seven high-risk New Haven neighborhoods. It provides housing financial assistance and financial education to recently incarcerated people and their families, and trains local residents in trauma-informed counse…

This study looks at whether taking antibiotics for just one day after a cat bite to the hand or forearm works as well as the usual five-day course, or even a placebo. About 72 adults who are bitten and seek care within 24 hours will be randomly assigned to one of three groups. Th…

This study tests smart textile socks that monitor foot pressure and movement in youth football players aged 14 to 18. The socks provide instant feedback to help players adjust their technique and reduce the risk of lower limb injuries. Researchers will compare injury rates and mo…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study looks at whether playing music of a patient's choice during wound dressing can lower stress and make the experience better. About 50 hospitalized adults will be randomly assigned to either listen to music or receive standard care. Researchers will measure heart rate, b…

This study compares three different wrist positions (bent back, straight, or bent forward) in a 3D-printed hand splint used after flexor tendon repair. About 64 people who had surgery on finger tendons will be randomly assigned to one of three splint positions and follow the same…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study tests whether adding regional anesthesia, such as nerve blocks, to standard pain treatment can reduce opioid use and pain after pelvic or acetabular fracture surgery. Adults undergoing surgery for these fractures may receive ultrasound-guided nerve blocks with a long-a…

This study tests whether a 4-week exercise program delivered through a smartphone app works as well as supervised sessions with a physical therapist before anterior cruciate ligament (ACL) knee surgery. Sixty-six adults aged 18 to 45 with an ACL tear will be split into three grou…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a special care program designed for older adults (65+) who live alone and have limb injuries. The program, led by a nurse practitioner, includes six educational units to support recovery. Researchers will measure whether it helps reduce pain, depression, and lone…

This study tests an injection called IS-001 that makes ureters glow under special imaging during robotic colorectal surgery. The goal is to help surgeons see the ureters more clearly and avoid accidentally injuring them. About 146 adults having robotic-assisted colorectal surgery…

This study tests a sleep program for people hospitalized after a leg injury that needed surgery. The program includes sleep medicine, melatonin, and sleep tips. Researchers want to see if it helps patients sleep longer and better, and if it reduces the need for strong painkillers…

This trial tests whether infrared laser therapy can relieve pain and speed healing in people with chronic venous leg ulcers — slow-healing wounds on the lower leg caused by poor blood flow. About 20 adults with ulcers lasting more than four weeks will receive either real laser tr…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…

This study tests two types of ankle foot orthoses (AFOs) — advanced braces that store and release energy versus conventional ones — in veterans and warriors with lower limb injuries. Researchers will measure mobility, balance, and confidence in daily activities to see if the newe…

This study looks at whether surgically repairing a nail bed injury leads to better nail appearance and less pain compared to just cleaning and bandaging the injury. About 100 people with nail injuries will be randomly assigned to one of the two treatments. The goal is to find out…

This study looks at whether a special prosthetic ankle that reads muscle signals can help people with below-knee amputations improve their balance and stability. About 50 adults who have had an amputation for at least two years will train with this powered ankle and be compared t…

This study tests whether a device that delivers high-frequency radiofrequency electrical currents (called TECAR) can reduce pain and improve movement in people with muscle injuries or low back pain. Researchers will measure pain, flexibility, and function before and after a singl…

This study tests the Point Mini, a mechanical finger prosthetic, in 14 children aged 3-17 with partial hand differences from amputation or birth. Each child uses their current device for one month, then the Point Mini for two months, to compare hand function, ease of use, and how…

This study tests whether a walking program on uneven surfaces can improve walking skill and confidence for people who use a lower-limb prosthesis. Thirty-five adults with leg amputations will practice walking on flat and uneven treadmills for four weeks. Researchers will measure …

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have ongoing pain after a serious orthopedic injury. Researchers want to see if it's possible to run a larger study by checking how many people sign up, attend sessions…

This study compares two ways of delivering cognitive processing therapy (CPT) to pregnant women with posttraumatic stress disorder (PTSD). One group receives standard weekly therapy sessions for 12 weeks, while the other gets an intensive schedule of 10 sessions over just 5 days.…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study looks at mothers who feel severe pain during a C-section despite spinal or epidural anesthesia. It compares giving general anesthesia versus extra pain medicine to see which better prevents post-traumatic stress disorder (PTSD). The goal is to find a way to reduce trau…

This study tests a silk-based wound dressing against a standard adhesive dressing in 50 adults undergoing double-incision mastectomy for female-to-male gender affirmation. Each patient serves as their own control, with one side of the chest getting the silk dressing and the other…

This study tests whether adding virtual reality (VR) exercises to standard physical therapy can improve hand function, reduce pain, and speed recovery in adults with traumatic wrist or hand injuries. About 40 participants will receive either usual rehab alone or usual rehab plus …

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether hypnosis before getting stitches in the emergency room can lower pain and stress. 180 adults with stitchable wounds will either receive standard care or a short hypnosis session before the procedure. The main measure is heart rate variability, and patient…

This study looks at how older adults (ages 65-74) who live alone and have limb injuries experience recovery. Researchers are testing a special "Geriatric Trauma Care Program" to see if it can improve pain, daily function, mood, and loneliness. About 110 participants will join for…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study tests a special gel dressing called Plurogel against standard burn dressings in people with partial thickness burns on the face or one limb. The goal is to see if Plurogel helps burns heal faster, reduces pain, and lowers the need for skin grafts. About 25 adults will …

This study tests whether a structured prenatal yoga program can reduce how traumatic women perceive childbirth to be, and improve their self-image and delivery preferences. Forty-six pregnant women in their second trimester or later will attend eight yoga sessions over four weeks…

This pilot study tests whether a gel called PluroGel®, used with standard dressings, can help burn injuries heal better and reduce the need for skin grafting. Twenty adults with similar burns on both arms or legs will have one limb treated with the gel and the other with standard…

This pilot study tests whether a trauma-focused therapy (TF-CBT) adapted for autistic youth is practical and well-received in community mental health centers. About 24 autistic children and their therapists will participate. The goal is to see if the therapy is acceptable and fea…

This study tests whether adding shock wave therapy to standard hand rehab can improve movement, reduce pain, and increase grip strength after a flexor tendon injury. About 56 adults who had tendon repair surgery 8-12 weeks ago will take part. Half will get usual rehab, and the ot…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests whether a structured nutrition plan helps people recover physical function after abdominal trauma surgery. Participants are adults in the ICU who need nutrition through an IV. They are randomly assigned to either the structured plan (IV nutrition, then shakes for…

This study tests a 3D-printed adapter that snaps onto an Xbox controller, allowing children aged 7 to 17 with a one-sided upper limb difference to use almost all buttons with one hand. Researchers want to see if it improves gaming performance and enjoyment. Twenty participants wi…

This study looks at whether a new preservative-free eyelid cream helps people feel more comfortable after eyelid surgery. About 30 adults who are planning eyelid surgery will use the cream twice a day for 3 months. Researchers will measure how satisfied patients are with their ey…

This study tests Emotional Freedom Techniques (EFT), a stress-reduction method that involves tapping on specific body points, in smokers who have failed standard quit programs. Researchers want to see if EFT can improve quit rates by reducing anxiety and cravings. The trial enrol…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD or depression after a sexual assault. Researchers want to see if this brief treatment reduces distress and is helpful to participants. The study involves 45 adults in Ohio who experience…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This pilot study tests whether a topical diclofenac gel (Voltaren) works as well as oral ibuprofen for reducing pain in children aged 6-18 with ankle or knee sprains. Sixty participants will use either the gel or oral medicine three times a day for three days, then report their p…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using a medical glue (cyanoacrylate bioadhesive) instead of stitches to close the wound on the roof of the mouth after gum graft surgery leads to less pain and faster healing. Sixty-six healthy adults will be randomly assigned to receive either stitches o…

This study compares two sedation approaches—dormicum-ketamine versus dexmedetomidine—to see which better prevents emergence delirium (confusion and agitation) in children aged 3 to 16 with burns. Sixty kids undergoing burn dressing changes or minor procedures will be randomly ass…

This study aims to find out which parts of behavioral therapy work best for children aged 8-17 with PTSD after a traumatic event. Researchers will compare different therapy components, like emotion regulation and exposure, to a placebo. 200 children and their caregivers will part…

This study tests whether acupuncture can relieve symptoms of Gulf War Illness, a condition causing long-term health problems in veterans who served in the Gulf region. Two hundred veterans will be split into two groups: one gets acupuncture twice a week for six months, the other …

This study tests a new EEG neurofeedback system called Prism for treating PTSD in 250 US veterans and civilians. Participants do 15 sessions of Prism training over 8 weeks, plus two booster sessions. The goal is to see if Prism reduces PTSD symptoms more than a sham (fake) traini…

This study compares two blood-derived gels (Alb-PRF and PRF) against a standard gelatin sponge for reducing pain and improving healing after a gum graft. 39 adults needing a gum graft will be randomly assigned to one of three treatments applied to the wound. Pain, healing, and co…

This study tests whether a nasal spray of fentanyl or ketamine can relieve moderate to severe pain from limb injuries in children (ages 2-17) faster than oral morphine. About 300 children in the emergency room will be randomly assigned to one of the three medicines. The goal is t…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests whether providing medically tailored meals and shakes for 12 days after orthopaedic trauma surgery can improve healing and reduce wound complications. Researchers will track metabolic markers and wound issues in 75 patients over one year. The goal is to see if be…

This study tests whether an advanced balance perturbation training program can help warfighters with lower limb trauma—such as amputations or limb salvage—recover better. Researchers want to see if it increases weight-bearing on the injured limb and reduces stumbles and falls. Th…

This pilot study tests whether using a pelvic wand for perineal massage in late pregnancy and during labor can help women feel more in control and reduce pelvic injuries. Researchers will enroll 140 pregnant women at Beth Israel Deaconess Medical Center. Participants will either …

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study tests whether a kit containing perineal ice packs, medicated witch-hazel pads, and benzocaine spray can reduce pain after vaginal surgery. Seventy women undergoing perineorrhaphy or posterior colporrhaphy will use the kit alongside standard care. The goal is to see if …

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of opioids patients need after surgery. 70 adults with facial fractures will be randomly assigned to receive either the nerve block or a placebo. The goal is to se…

This study is checking how safe and effective a special dressing (3M V.A.C. Peel and Place) is when used with a standard wound vacuum therapy. About 90 adults with open wounds or surgical incisions will be treated and monitored. The goal is to see if the dressing helps wounds clo…

This early-stage study tests a topical spray called ELU42 on 15 adults with diabetic foot ulcers (Wagner grade 1-2) that have lasted 4 to 52 weeks. The spray is applied three times a week for six weeks. The main goals are to check safety and measure how much the wound shrinks. Th…

This study looks at whether core stabilization exercises can improve hand function and emotional health in men recovering from traumatic hand injuries. Fifty-one men aged 20-50 will be split into three groups: standard hand rehab alone, standard rehab plus supervised core exercis…

This study tests whether a cold plasma device applied during and after thyroid surgery can speed up wound healing and reduce pain and infection. About 26 adults having their thyroid removed will be randomly assigned to get either standard wound care or the plasma treatment. Resea…

This study looks at whether a prosthetic knee with a built-in computer (microprocessor-controlled) can help people with above-knee amputations have fewer fall-related problems, walk faster, and feel better overall. About 100 adults who already use a basic prosthetic knee will eit…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests a gel called Nano Bio Fusion (NBF) to see if it helps heal wounds on the roof of the mouth after gum graft surgery. About 36 adults will apply either the NBF gel or a placebo gel four times a day for four weeks. Researchers will measure wound size, pain, and infl…

This study tests whether a guided therapy using psilocybin (the active ingredient in magic mushrooms) can safely help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions combined with talk therapy. The goal is to reduce PTSD symptoms and improve long-…

This study looks at how well a special implant (IlluminOss) works for people with pelvic fractures from cancer that has spread or from aging. The goal is to see if it reduces pain and helps patients move better. About 100 adults will be followed for up to 2 years after surgery, r…

This study tests a new approach called PEARL that uses photography and reflective listening to help survivors of interpersonal violence. 40 women will either receive the intervention right away or after a 3-month wait. Researchers will check if it reduces barriers to seeking help…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study tests a short intervention called iCOVER, designed to help people quickly regain focus and calm after an acute stress reaction. The intervention takes just 60-120 seconds and can be given by peers or medical staff. Researchers will enroll 450 adults in an emergency dep…

This study tests two ways to temporarily move the gums so dentists can make better-fitting crowns or bridges. It compares a traditional retraction cord with an aluminum chloride gel in 66 adults aged 18-50. The goal is to see which method works faster, causes less bleeding, and g…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests a device that delivers oxygen to chronic leg ulcers caused by vein problems. About 212 adults will get either the real oxygen therapy or a sham treatment, along with standard compression bandages, for up to 16 weeks. The main goal is to see if the oxygen therapy …

This study compares a new powder dressing called Altrazeal to standard burn dressings in adults with partial thickness burns. The goal is to see if the new dressing reduces pain during changes and helps wounds heal faster. Sixty hospitalized patients will be randomly assigned to …

This study tests whether a single intravenous dose of allopregnanolone, compared to a placebo, can help people with PTSD better process and reduce the power of traumatic memories. The trial involves 96 adults with chronic PTSD and uses skin conductance and startle responses to me…

This study tests a short therapy program called EMPOWER for family members who make decisions for critically ill patients in the ICU. The therapy includes breathing exercises, mindfulness, and coping techniques delivered by a mental health professional. Researchers will compare i…

This study tests whether a closed incision negative pressure wound therapy (ciNPWT) device can reduce wound complications after breast reduction surgery. 92 women will have one breast treated with the device and the other with standard adhesive strips. The goal is to see if the d…

This study tests a new prosthetic foot called the Caesar foot in real-world settings. About 18 adults with below-knee amputations who want to run will use the foot at home for two months. Researchers will check if it improves mobility and daily activity compared to their usual fo…

This study is checking if a special collagen wound dressing called HealiAid is safe for people who have had breast tumor surgery. About 60 adults aged 18-70 with small breast tumors (benign or malignant) will receive the dressing right after their tumor is removed. Researchers wi…

This early study tests whether a new oxygen-delivery system using micro/nanobubbles can safely help heal different types of wounds. About 40 adults with acute or chronic wounds will receive either the oxygen bubbles or a standard saline treatment. Researchers will measure changes…

This study tests two sedative drugs, remimazolam and midazolam, in adults aged 65 and older having orthopedic surgery with regional anesthesia. The goal is to see which drug provides better sedation during surgery and causes fewer problems with thinking and memory shortly after. …

This study tests whether a combination of famotidine (Pepcid) pills and cromolyn sodium lotion can reduce itching from burn scars. 44 adults with itchy burn scars will take either the active combo or a placebo (plus a standard antihistamine) for 6 months. The main goal is to see …

This pilot study tests whether training obstetric clinicians in trauma-informed care can improve mental health and mother-child bonding in pregnant women who experienced childhood abuse. Sixty first-time mothers in Buenos Aires will receive care from trained providers, and resear…

This study tests a new cream made with ceramide, coconut oil, and cholesterol to see if it improves skin hydration, redness, and itch in people with mild skin barrier problems like eczema, psoriasis, or dry skin. 26 adults will apply either the new cream or plain petrolatum twice…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study tests whether brief educational videos delivered by text message can help young people aged 15-25 manage symptoms of post-traumatic stress disorder (PTSD). Participants are randomly assigned to receive the videos right away or after a 5-month wait. The study is fully o…

This study compares two breathing support methods for people with chest trauma who have low oxygen levels. One group gets a high flow nasal cannula, the other a standard oxygen mask. The goal is to see if the nasal cannula reduces the need for a breathing tube or pneumonia. About…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

Researchers at a hospital in Iraq are studying whether a chest injury scoring system can predict which trauma patients will die or need intensive care. The study enrolls about 166 patients over age 16 who arrive at the emergency department with chest trauma. Doctors score each pa…

This study looks at how well people recover 12 months after an Achilles tendon rupture treated without surgery, using a specific rehabilitation program called the SMART protocol. Researchers will measure ankle strength with a machine and ask participants about their daily functio…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

This study is a registry that will collect information from about 200 people who receive a total jaw joint (TMJ) replacement. Researchers will track their health, jaw function, and any complications for up to 5 years after surgery. The goal is to learn more about how these replac…

This study follows 1,000 caregivers and their high-risk infants who use the SNOO Smart Sleeper Bassinet at home. Researchers will track any serious injuries or deaths linked to the device to see how safe it really is. The goal is to gather real-world safety data for babies at hig…

Researchers at a French hospital are interviewing girls and young women aged 12 to 25 who receive care in child and adolescent psychiatry and who view pornographic content. Through semi-structured interviews, the study explores when and how participants first encountered pornogra…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

Researchers at Lille University are following 350 people, including cancer patients recently diagnosed with breast, gynecological, testicular or digestive cancer, their caregivers, and healthcare professionals. Over one year, participants answer questionnaires about post-traumati…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This study follows 185 adults in the Netherlands who are hospitalized with serious trauma injuries. Researchers will ask them to fill out short questionnaires about their quality of life, pain, fatigue, and daily functioning at several points over a year. The goal is to see wheth…

This study aims to understand the psychological and social factors that influence how well people accept and use an upper limb prosthesis after amputation. Researchers will interview and survey over 170 adults with unilateral arm amputations to build a model that predicts outcome…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells called myeloid cells. Researchers want to understand why these changes can lead to ongoing inflammation and a weakened immune system. The study will follow …

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study gathers information from trauma patients with a specific type of brain bleed called acute subdural hematoma. Researchers will look at standard surgeries and a newer procedure to see which works best. The goal is to learn from past cases to guide future treatment. No ne…

This study follows 100 people with advanced gum disease (Stage III or IV) who undergo regenerative periodontal surgery. Researchers track how the surgical site heals in the first one to two weeks and then check whether that early healing pattern relates to gum health and bone cha…

This pilot study explores whether an electrical impedance tomography (EIT) device can detect soft tissue injury in adults who have suffered high-energy fractures of the arms or legs. Participants will undergo EIT imaging in the emergency department, operating room, clinic, and ho…

This study tests whether a light-based imaging tool called optical coherence tomography (OCT) can spot bacteria or biofilm on bone, tissue, and surgical hardware during open fracture or infected fracture surgery. Researchers will enroll 40 adults to see if the technique is practi…

This study investigates how the community of bacteria in the mouth and gut changes after sepsis or severe trauma in people who have been in the intensive care unit. Researchers will compare these patients to healthy individuals to see if microbiome disruption is linked to ongoing…

This study aims to establish normal knee rotation values in healthy athletes who play pivot sports like soccer or basketball. Researchers will measure knee rotation in 482 athletes using a device called DYNEELAX. The goal is to better understand what is normal, so doctors can ide…

This study looks at whether a harmless thermal camera can help doctors see how surgical wounds are healing after skin surgery. About 120 adults having skin lesions removed will have their wounds photographed with the camera. The goal is to catch problems like infection or slow he…

This study compares carbon dioxide emissions from orthopedic surgeries performed with different materials and setups. Researchers will track waste, energy use, and sterilization methods for procedures like carpal tunnel release or wound revision. The goal is to identify ways to r…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study follows about 400 young rugby players (ages 12-18) from Rugby Club Toulonnais over two seasons. Researchers will record every injury that needs medical care, noting how often injuries happen, how serious they are, and what types occur. The goal is to understand injury …

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…

This study will review medical records of 100 trauma patients with colon injuries treated at Methodist Dallas Medical Center. Researchers want to see which surgical approaches lead to the best outcomes. No new treatments are being tested; instead, the goal is to learn from past c…

This study explores whether injecting special skin cells (fibroblasts) can change normal skin into the thicker skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. They will measure changes in cell …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study is observing nearly 2,700 active-duty service members to find out what makes them more likely to get muscle or bone injuries. Participants will do physical tests and answer questions to identify risk factors. The goal is to create better ways to prevent injuries and he…

This study tests whether keeping the thumb in a cast for four weeks after surgery reduces the risk of tendon rupture compared to the standard early active motion therapy. About 380 patients in Sweden will be randomly assigned to one of the two rehab programs. The goal is to find …

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study enrolls people who have already had a hand or arm transplant to collect information over time. Researchers will measure hand function, pain, quality of life, and mental well-being using questionnaires and tests. The goal is to better understand the long-term safety and…

This study looks at whether people with a torn ACL have weakness in the soleus, a calf muscle that helps protect the knee. Researchers will test leg strength in 55 participants with ACL tears and compare them to healthy individuals. The goal is to better understand muscle changes…

This study looks at how different laser energy levels affect skin damage and repair. Twenty healthy Chinese women will receive various laser doses on their forearms. Researchers will track changes in skin color, moisture, and healing over 10 days. The goal is to create a model fo…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This observational study will collect movement data from 5,000 healthy athletes aged 10 to 65 who play organized sports. Researchers will track participants for 12 months to see who gets injured, especially ACL tears. The goal is to build a database of normal movement patterns to…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study is evaluating a hospital-based violence intervention program called Turning the Tide for people treated after a violent injury. Researchers will track 220 patients to see if the program reduces PTSD, depression, and repeat injuries, and improves self-esteem and access …

This study looks at whether online driver training can help reduce crash risk for new teen drivers. Researchers will enroll 1,300 adolescents aged 16-17 in Pennsylvania who have a learner's permit. Participants will complete online safety education or skills training, and their d…

This observational study follows 30 women undergoing DIEP flap breast reconstruction after mastectomy. Researchers will measure inflammation and oxidative stress markers in blood samples taken before and after surgery. The goal is to understand how the body responds to the tempor…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study is a small pilot trial to see if giving older adults a nerve block (a numbing injection) before leg fracture surgery is feasible for a larger study. Researchers want to know if this approach can reduce complications and improve recovery, beyond just pain relief. About …

This study measures how loose the knee is during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. Researchers use a navigation system and a special device to track knee movement in real time. The goal is to gather data that may help improve surgical tech…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study checks how well a tool called the STUMBL score predicts serious outcomes like death or ICU need in people with blunt chest injuries (from car crashes or falls). About 188 adults in Iraq will be scored when they arrive at the ER, and their results will be tracked. The g…

This study will enroll 200 multiple trauma patients at a trauma center in Iraq to see which of two scoring systems—the Revised Trauma Score (RTS) or the MGAP score—better predicts who will die or have complications. Patients will be scored upon arrival and followed during their h…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study compares two scoring systems, MGAP and GAP, to see which better predicts outcomes like death, hospital stay length, and need for surgery in people with multiple injuries. About 522 adults with trauma will be scored when they arrive at the emergency department, and thei…

This study looks at the forces applied to the tongue and throat during laryngeal surgery. Researchers will measure these forces in 100 adults and see if they relate to pain, numbness, or tongue movement after surgery. In the second half of the study, surgeons will see real-time f…

This study looks at how past sports injuries and a sedentary lifestyle may lead to chronic disease, pain, and disability in former athletes. Researchers will compare strength, function, physical activity, and heart health among current and former college athletes and non-athletes…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study watches veteran football players (men over 35) to see how their training habits and overall health relate to getting injured. Participants fill out surveys about their training, lifestyle, and health, and report any injuries during the season. The goal is to find patte…

This study is collecting information from 11,000 people who have had a heart attack or heart muscle injury. Researchers want to learn more about these conditions to improve future treatment. The study does not test a new drug or procedure, but instead gathers data to better under…

This study aims to understand how a concussion changes the way people move, which may increase their risk of muscle and bone injuries. Researchers will compare movement patterns in 148 military members who have had a concussion with those who have not. The goal is to find specifi…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why some have worse outcomes, including death. Researchers will track health events and build a risk score to identify those most at risk. The goal is to better understand the disease and improve…

This study aims to improve emergency care for injured children in Tanzania by finding and fixing delays in the healthcare system. Researchers will work with local clinics and hospitals to create a better triage process, helping kids get the right care faster. About 284 patients, …

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks are involved. The goal is to learn how therapy works in the brain, which cou…

This study looks at how changing the stiffness of the footplate in a carbon fiber leg brace (called a custom dynamic orthosis) affects foot pressure, walking mechanics, pain, and comfort. Twenty healthy adults will wear the brace with different footplate stiffness levels while re…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at what happens to blood and bone marrow after a severe injury. Researchers want to understand why some trauma patients develop a weakened immune system and get serious infections like sepsis. About 255 adults with severe fractures will give blood and a small bon…

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study looks at whether a special combination of blood products and medication (fibrinogen, plasma, and tranexamic acid) can be given to trauma patients with life-threatening bleeding while still in the ambulance. The goal is to see if this approach is practical and safe. Onl…

This pilot study is testing whether two established trauma therapies—Prolonged Exposure and EMDR—can be safely used in young adults with psychotic disorders who also have PTSD symptoms. Twenty participants from the OPUS early-intervention program will receive one of the therapies…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study looks at how the jawbone changes right after a tooth is pulled and a bone graft is placed. Researchers want to see if the bone expands or stays the same right after extraction, and how that affects bone width and height four months later. The goal is to better understa…

This study collects plucked hair follicles from 100 healthy volunteers to see if cells from them can be grown and turned into stem cells. Researchers will then try to turn those stem cells into pancreatic or blood cells for disease modeling and future cell replacement therapies. …

This study examines the link between psychological readiness, knee function, and muscle strength in athletes who had ACL reconstruction surgery. Researchers will measure mental readiness using a special scale and test knee strength with a machine. The goal is to understand why so…

This study looks at how trauma experienced by parents can affect their children, both biologically and behaviorally. Researchers will compare families directly exposed to a traumatic event with those who were not. Using brain scans, interviews, and tests, they aim to understand h…

This study looks at how connective tissue in muscles and tendons repairs itself after an injury. Forty people scheduled for knee surgery will receive either growth hormone or a placebo, with or without electrical stimulation to their hamstring muscles. Researchers will measure pr…

This study tests a new computer tool that creates a 3D model of a broken shinbone to help surgeons plan where to place screws and plates before surgery. The tool uses the patient's own CT scan to simulate different repair options. About 40 adults with a lower leg fracture will ta…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study follows 110 adults with acute tears or holes in the esophagus or rectum who are treated with a medical device called Suprasorb CNPendo. Researchers will track how long it takes for patients to start eating again or have their stoma closed. The goal is to see how well t…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …

This study aims to find the best way to place sensors on a prosthetic socket to improve how well people with below-elbow amputations can control their powered arm. Researchers will compare different numbers of sensors (4, 8, or up to 16) and whether targeting specific muscles hel…

This study tests whether powered prosthetic knees help people with above-knee amputations walk more and feel more confident than standard non-powered knees. Twenty-six adults who already use a mechanical knee will try both types at home for three months each. Researchers will tra…