HIV infectious disease

This study tested an experimental HIV vaccine in 132 healthy, HIV-negative adults. The vaccine uses a harmless virus (ALVAC) to deliver HIV proteins, plus a protein boost (gp120) with an adjuvant to strengthen the immune response. The main goals were to check safety and measure w…

This study tests an experimental vaccine called GBS-NN/NN2 against Group B Streptococcus (GBS), a bacteria that can cause serious infections in newborns. The trial includes pregnant women both with and without HIV, giving two doses between 26 and 30 weeks of pregnancy. Researcher…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study looks at children and teens with HIV to find the best number of HPV vaccine doses. Researchers are comparing one, two, or three doses to see if fewer shots can still provide strong protection against HPV. The goal is to simplify vaccination and improve health outcomes …

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This study tested an experimental HIV vaccine in 117 healthy, HIV-negative adults to see if it is safe and triggers an immune response. Participants received several injections of the vaccine or a placebo. The main goals were to check for side effects and measure antibody levels.…

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an upda…

This study tested four different HIV vaccine combinations in 92 healthy volunteers at low risk of HIV infection. The goal was to see which combinations were safest and best at triggering an immune response. Researchers used a prime-boost approach, giving an initial vaccine follow…

This study tested two different schedules of an experimental HIV vaccine in 147 healthy adults to see which one triggers a stronger immune response. Volunteers received either three DNA shots followed by one booster, or two DNA shots followed by two boosters. The goal was to find…

This study tested whether a double-dose hepatitis B vaccine (40 micrograms) works better than the standard dose (20 micrograms) in people with HIV who did not respond to earlier hepatitis B shots. The goal was to see if the stronger dose could help their immune system produce eno…

This study tested three different ways of giving the hepatitis B vaccine to 437 people with HIV whose CD4 counts were above 200. The goal was to see which schedule—standard dose, double dose, or skin injections—works best to protect them from hepatitis B, a virus that can cause s…

This study tested different COVID-19 booster vaccines (Janssen, Moderna, Pfizer, Novavax) in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. Some participants had HIV, and others did not. The goal was to see if mixing vaccine t…

This study tested an experimental HIV vaccine in 65 healthy adults to see if it is safe and triggers an immune response. The vaccine includes two HIV proteins (A244 and B.63521) plus an adjuvant (ALFQ) to boost the immune system. Participants received three shots over two months,…

This early-stage trial tested an experimental HIV vaccine in 38 healthy infants born to HIV-positive mothers. The vaccine was designed to teach the immune system to recognize HIV. The main goal was to see if it was safe and whether it triggered an immune response. The study is co…

This early-stage trial tested an experimental HIV vaccine called Trimer 4571 in 32 adults with HIV who were already on effective antiretroviral therapy (ART). The main goal was to check if the vaccine is safe and tolerable, and to see if it helps the immune system produce broadly…

This early-stage trial tested two experimental HIV vaccines in 34 healthy, HIV-negative adults. The goal was to see if the vaccines were safe and whether they triggered an immune response. The vaccines use a harmless chimpanzee virus to deliver HIV proteins, followed by a booster…

This study looked at how well the Pfizer mRNA vaccine triggers an immune response in people with weakened immune systems compared to healthy individuals. About 539 adults received two doses of the vaccine, and researchers measured antibody levels and side effects. The goal was to…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

Researchers are testing whether switching from a standard three-drug HIV regimen to a two-drug regimen keeps the virus under control just as well. The trial enrolls 134 adults whose HIV is already suppressed on a three-drug regimen and randomly assigns them to continue that regim…

Researchers are testing whether a telehealth counseling program can reduce heavy drinking and improve HIV viral control in people with HIV. Participants receive either a single brief alcohol counseling session or that session plus a referral to a program with multiple video couns…

This study adapts a wellness program called Chetana to help men who have sex with men (MSM) and transgender women (TGW) in India who are living with HIV stay engaged in care. The program includes yoga, nutrition, legal advice, mental health support, and peer navigators who provid…

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

Researchers at the University of Miami are testing two ways to help men who have sex with men take their HIV prevention medication, known as PrEP, more consistently. One group receives four weekly counseling sessions with a nurse, using techniques from cognitive behavioral therap…

Researchers are studying whether trained community workers can safely deliver HIV treatment outside clinics in Cambodia. The trial enrolls about 4,000 people living with HIV who have stable treatment and no complications. Community action workers receive training to dispense drug…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

Researchers at UT Health San Antonio are testing a mobile app called PL4Y to see if it helps young people recently diagnosed with HIV stay connected to medical care. The pilot study enrolls 29 participants who either have a recent diagnosis, a high viral load, or have missed HIV …

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

Researchers are testing whether a once-daily form of raltegravir can keep HIV suppressed in adults who already have the virus under control with standard antiretroviral therapy. The trial enrolls about 100 adults with HIV-1 who have been on stable treatment for at least six month…

In sub-Saharan Africa, tuberculosis often causes sepsis in people living with HIV, and many die within days. This phase 3 trial tests two changes to standard care: starting anti-TB therapy right away instead of waiting for test results, and using a higher, sepsis-specific dose in…

Researchers are testing whether a daily pill combining dolutegravir and lamivudine keeps HIV suppressed in adults whose virus is already under control but who have a history of resistance to lamivudine. The study enrolls 167 participants who switch from their current HIV treatmen…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study evaluates a program for HIV-positive adolescent girls and young women who are pregnant or parenting. The program offers education on sexual health, support groups, skills development, mentorship, and involvement of young fathers. Researchers will measure resilience and…

This trial tests whether kidneys from deceased HIV-positive donors can be safely transplanted into people living with HIV. Researchers track major complications like graft failure, serious side effects, and HIV progression. The goal is to see if using these organs is a safe way t…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

Researchers are testing a smartphone game called MyGoals to see if it can help adolescents living with HIV in Kenya stay engaged in their care. The game includes role-playing, mini-games, and personal goal-setting to boost knowledge, attitudes, and confidence around treatment and…

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study is testing two mobile health tools—a computer-delivered program and motivational text messages—to help young adults (ages 18-24) in Zambia better manage their HIV and cut down on alcohol use. The goal is to see if these tools are easy to use and acceptable to participa…

This pilot study tests whether people with HIV who receive routine care at a community center, instead of a hospital, feel more satisfied with their care. Researchers will compare satisfaction between two groups: one getting care at the community facility and one continuing usual…

This trial tests a counseling program called ImpACT+ for women in South Africa who have HIV and a history of sexual trauma. The program combines HIV treatment adherence support with coping skills to address traumatic stress. Researchers will compare viral suppression rates and ca…

This early-phase trial tests whether a combination of two experimental vaccines, an immune booster, and two powerful antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. Eleven participants will receive the regimen while on ART,…

This study tests whether adding video to home telehealth services helps people with HIV stay engaged in their medical care, which is crucial for managing the illness. Participants use VA Video Connect on their own devices to attend appointments with their care team. The trial als…

Severe acute malnutrition affects millions of children worldwide and often leads to death after hospital discharge. This phase 3 trial tests whether giving a combination of antibiotics (rifampicin, azithromycin, isoniazid, and vitamin B6) for several weeks can lower the risk of d…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is an acceptable and feasible way to treat cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it a…

This study tests whether a structured transition-of-care program can improve support for adults in Malawi who are hospitalized with both HIV and a chronic condition like high blood pressure. The program includes discharge planning, nurse home visits within a week, and community f…

This study tests whether two lab-made antibodies can safely control HIV in people who stop their regular antiretroviral therapy for a short time. Thirty-two adults in Sub-Saharan Africa who are currently on HIV treatment will receive either the antibodies or a placebo. The goal i…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests a community-based program called VINA STEAM, designed to help gay and bisexual men in Ho Chi Minh City cope with stress and HIV-related stigma. Participants join small peer-led groups to build skills that may reduce minority stress and stigma. The study measures …

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This study in Zambia evaluates whether dedicated 'viremic clinics'—where people with HIV who have high viral loads receive extra support from a team of healthcare providers—can improve viral suppression. The trial includes 548 participants aged 15 and older who have been on first…

This phase 3 trial asks whether a dolutegravir-based HIV regimen works as well as or better than an efavirenz-based regimen in pregnant women living with HIV-1. The study compares how well each treatment suppresses the virus at delivery and checks safety for both mothers and thei…

This study tested a program called SYV (The Voice of Youth) to see if supporting mental health helps young people with HIV take their medication regularly. 690 youth aged 10-24 in Tanzania took part. The goal was to improve viral suppression by addressing mental health challenges…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This study looks at how well the drug ibalizumab works for people with multidrug-resistant HIV in everyday medical practice. It compares patients who receive ibalizumab plus other HIV drugs to similar patients who do not receive ibalizumab. The goal is to understand long-term vir…

This study looked at two strategies to help Ugandans living with HIV and high blood pressure get better care. One strategy provided free blood pressure medicines and equipment, while the other added extra staff and support. Over 87,000 patients took part. The goal was to see whic…

This trial tests whether giving small cash payments to HIV-positive pregnant women in Nigeria can encourage them to stay in care and reduce the chance of passing HIV to their babies. Women who register their pregnancy, pick up their medication, deliver at a clinic, and get their …

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study surveys HIV-positive adults who switch from taking two or three pills to a single pill containing the same three medicines (tenofovir, emtricitabine, and efavirenz). Researchers want to know if the simpler regimen improves how well patients take their medication, how t…

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This study looked at whether taking vitamin D3 for 3 months can lower inflammation and boost immune cells in people with HIV who are already on antiretroviral therapy. Twenty adults with early-stage HIV took vitamin D3 supplements. Researchers measured changes in inflammation mar…

This study looks at whether CABENUVA, a long-acting injectable HIV medication, is safe and effective for people with HIV who also have severe kidney impairment, including those on dialysis. Participants receive the drug as monthly or every-2-month injections. The goal is to see h…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study looked at how safe and tolerable the drug bedaquiline is for children and teens with rifampin-resistant tuberculosis, including those also living with HIV. Fifty-four participants received bedaquiline along with their regular TB treatment for 24 weeks. Researchers meas…

This study looked at whether adults aged 50 and older living with HIV could safely switch from a three-drug pill to a simpler two-drug pill (DTG/3TC) while keeping the virus under control. About 200 participants who already had undetectable virus levels made the switch and were f…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tests different ways to help people with HIV take their medication regularly. Researchers will enroll 534 people starting HIV treatment in Cape Town. They will use a device to track pill-taking and try different outreach methods, like calls or texts, to support adheren…

This study tests a program called Maisha (Swahili for 'life') that aims to reduce HIV stigma among pregnant women and their male partners entering antenatal care in Tanzania. The program includes a video and counseling session before HIV testing, plus extra support for those who …

This trial tests a community-based approach to HIV prevention for young people aged 15-30 in rural KwaZulu-Natal, South Africa. Peer navigators guide participants to mobile clinics that offer sexual health services, including HIV testing, PrEP, and contraception. The goal is to r…

This study tests a mobile app designed specifically for Black adults living with HIV who smoke daily. The app includes culturally tailored content and anxiety-reduction techniques to support quitting. Participants are randomly assigned to use either the tailored app or a standard…

This study tests whether a synbiotic supplement (a mix of a prebiotic called 2'-FL HMO and a probiotic called B. infantis) can reduce infections and improve growth in infants who were exposed to HIV but are not infected themselves. About 140 infants will receive either the supple…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study in Kenya tests different behavioral strategies to help 880 adolescents and young adults (ages 14-24) with HIV stay engaged in care. Participants first get either standard care or electronic navigation. If they miss appointments or have unsuppressed virus, they are re-r…

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This study looked at whether starting antiretroviral therapy (ART) immediately (within 48 hours) versus waiting until an opportunistic infection is under control affects death rates in HIV/AIDS patients hospitalized with such infections. Researchers enrolled 114 adults with HIV a…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested a program where HIV nurses were trained to also manage high blood pressure in people living with HIV. The goal was to see if this approach could lower blood pressure over 12 months. The study involved 830 adults at 30 primary health centers in Lagos, Nigeria.

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tests a combination of three HIV drugs (amprenavir, lopinavir, and ritonavir) in patients whose current treatments are no longer working. The goal is to see if this new mix can lower the amount of HIV in the blood over 26 weeks. Participants are HIV-positive adults who…

This trial compares a once-daily combination of three HIV drugs (emtricitabine, didanosine, and efavirenz) to the standard multi-pill regimen containing a protease inhibitor. The goal is to see if the simpler daily pill works just as well at keeping the virus undetectable, while …

This study tested a once-daily combination of three HIV drugs (FTC, ddI, efavirenz) in 39 adults who had never taken HIV medication before. The goal was to see if this simpler, once-a-day pill routine worked well and had fewer side effects than older treatments. Participants had …

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This completed Phase 4 trial tested the HIV drug Biktarvy in 202 people who were newly diagnosed with HIV and had low CD4 counts (under 200), meaning they started treatment late. Participants received either Biktarvy or a standard three-drug combination. The main goal was to see …

This study tested whether personalized text message reminders can help young people with HIV take their medication consistently. 210 participants from 12 clinics received either standard care or tailored text reminders for 6 months. The goal was to see if the texts improved medic…

This study tested whether starting HIV treatment on the same day and providing care in community centers for people who inject drugs improves viral suppression. 800 participants were randomly assigned to same-day or standard treatment start, and to community or government-based c…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested whether daily cassava root and sesame seed granules, along with nutrition education, could improve the nutritional health of adults with HIV. Sixty-four participants took part, receiving either the granules plus education or education alone for 16 weeks. The goa…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study looked at two ways to control HIV in 171 adults who had never been treated before. Everyone started with a daily pill (dolutegravir/lamivudine). Once the virus was undetectable, participants could choose to switch to a shot (cabotegravir plus rilpivirine) given every t…

This study tested a simple tool that helps doctors choose the right stop-smoking medicines for people living with HIV. 371 smokers from three clinics took part. The goal was to see if the tool helped more people quit smoking for at least a week.

This study tested the safety and how the body processes the HIV drug dolutegravir in newborns whose mothers have HIV. A total of 48 mother-infant pairs from four countries participated. Infants received either a liquid or tablet form of the drug during their first weeks of life, …

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This early study tested a lab-made antibody called 3BNC117-LS in 43 people, some with HIV and some without. The goal was to see if it is safe and how long it stays in the body. If it works, this antibody might one day help control HIV with less frequent dosing.

This study tested a combination of peginterferon alfa2a and ribavirin in 17 HIV-positive people with chronic hepatitis C who had not responded to earlier treatment. Participants received weekly injections and daily pills for 48 weeks. The main goal was to see if the virus became …

This early-stage study tested a single injection of a new drug, lipovirtide, in 46 HIV-positive adults who had never taken antiviral medication. The main goal was to check if the drug is safe and how the body processes it. This is a first step toward finding new treatments to con…

This early-stage trial tested multiple doses of an injectable drug called lipovirtide in 24 adults with HIV who had never taken antiretroviral therapy. The main goal was to check safety and how the drug moves through the body, with a secondary look at whether it can lower HIV lev…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This pilot study tested a text-message game called iTAG that uses points, a scoreboard, and motivational messages to encourage young people with HIV in Ghana to take their medication regularly. Twenty-one participants aged 18-24 received the game for 90 days. Researchers measured…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested whether the BCG vaccine, normally used to prevent tuberculosis, could reduce the hidden HIV reservoir in people living with HIV who are on antiretroviral therapy. Sixty participants received either a single BCG shot or a placebo. Researchers measured changes in …

This study tested whether two lab-made antibodies, VRC01LS and 10-1074, could keep HIV under control in 30 children in Botswana who started treatment early. The children received the antibodies by infusion and stopped their regular HIV medication. Researchers monitored how many k…

This study looked at HIV-positive adults who switched from a standard three-drug therapy to either a two-drug or a three-drug regimen. Researchers wanted to see if the two-drug option could reduce long-term side effects while keeping the virus under control. The main focus was on…

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program aimed to improve HIV medication adherence and viral suppression through relationship strengthening.

This study tested a program that combined mobile health tools and peer support to help 541 Nigerian adolescents with HIV stick to their treatment and keep the virus under control. Participants were already on antiretroviral therapy and received the program for up to 48 weeks. The…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study tested whether special cookies made from Golden Rice and an herb called Piper crocatum could lower fasting blood sugar and improve quality of life in 102 people living with HIV who also have high blood sugar. Participants ate either the Golden Rice cookies or plain con…

This study tested whether people with well-controlled HIV can safely take their antiretroviral drugs only 4 days in a row each week, instead of every day. Over 600 adults with stable HIV participated. The main goal was to see if the 4-day schedule kept the virus suppressed just a…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study tested whether adding Interleukin-2 (IL-2) to standard HIV drugs could increase CD4 immune cells in patients whose current treatment was failing and who had very low CD4 counts (≤200). Fifty-seven adults with HIV-1 took part. The main goal was to see if their CD4 count…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study tested two versions of the H1N1 flu vaccine in 306 people living with HIV. One vaccine included an adjuvant (a booster ingredient) and the other did not. The goal was to see which vaccine was safer and better at protecting against the flu. Participants were followed fo…

This study tested two different once-daily HIV medication combinations in 101 people who had just been infected with HIV-1. The goal was to see which combo better lowered the amount of hidden virus in immune cells after 48 weeks. Both treatments are standard HIV therapies, so thi…

This study tested whether adding the drug maraviroc to standard HIV treatment could help improve immune function in people whose CD4 counts remain low even when the virus is well-controlled. It involved 60 HIV-positive adults with low CD4 counts and little recent immune improveme…

This study tested a more intensive hepatitis C treatment in 58 adults who have both HIV and hepatitis C (genotypes 1 or 4) and had not responded to previous therapy. Participants received higher doses of two drugs, peginterferon alfa-2a and ribavirin, for up to 18 months. The goa…

This study tested whether HIV patients with long-term viral suppression could switch to a single boosted drug (darunavir/r) instead of staying on a standard combination of drugs. 225 adults with well-controlled HIV took part. The goal was to see if the single-drug approach could …

This study tested whether adding an extra HIV drug (enfuvirtide) to standard treatment for 6 months helps people with very low CD4 counts recover their immune system faster. It included 195 adults newly diagnosed with HIV who had a high risk of getting AIDS. The goal was to see i…

This study looked at how the HIV drug raltegravir works in people with severe liver disease who need a liver transplant. It included 14 HIV-positive adults with end-stage liver failure. Researchers checked how the drug behaves in the body and how it interacts with anti-rejection …

This study looked at whether people with HIV who have their virus under control can switch from the injectable drug enfuvirtide to the oral pill raltegravir. 170 participants were randomly assigned to either stay on their current treatment or switch to raltegravir. The goal was t…

This study looked at 35 people with HIV who had never taken HIV drugs before. They all received a daily combination of three medications (atazanavir, ritonavir, tenofovir/emtricitabine) in special bottles that recorded every time they opened them. The goal was to measure how much…

This study tested whether a single HIV drug, darunavir/ritonavir, could replace the usual combination therapy in pregnant women with well-controlled HIV. The goal was to prevent mother-to-child transmission without using a class of drugs called NRTIs. 91 pregnant women already on…

This study tested whether people with HIV who have high immune cell counts (CD4 above 500) can safely take antiretroviral drugs in 6-month cycles—6 months on treatment, then 6 months off—instead of taking them every day. The goal was to see if this approach could keep their immun…

This study tested a two-drug combination of raltegravir and etravirine in 170 adults with HIV who were at least 45 years old and already had the virus well-controlled. Participants switched from a standard three-drug regimen to this simpler two-pill combo. After 96 weeks, over 98…

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This study tested a three-drug combination (raltegravir, emtricitabine, and tenofovir) as a first treatment for people with HIV-2, a less common form of HIV found mainly in West Africa. The goal was to see if this combination could control the virus better than standard treatment…

This study tested whether alendronate, a drug used for osteoporosis, can improve bone density in people with HIV. 140 participants received either alendronate or a placebo, along with calcium and vitamin D, for 2 years. The goal was to see if the drug could strengthen bones and r…

This study tests whether interleukin-2 (IL-2) can help maintain CD4 cell counts in people with HIV who have not yet started antiretroviral therapy. 130 participants with CD4 counts between 300 and 500 will receive IL-2 injections. The goal is to see if IL-2 can delay the need for…

This study looked at whether a lower daily dose of the HIV drug darunavir (400 mg instead of 800 mg) can keep the virus suppressed in people whose HIV is already well-controlled. The trial involved 100 adults with HIV who had undetectable viral loads for at least a year. The goal…

This study tested two different two-drug combinations in 61 HIV patients who had never taken protease inhibitors before. The goal was to see if these combinations could lower the amount of virus in the blood to very low levels (below 50 copies/mL) after 16 weeks. The study also c…

This phase 2 study tested a combination of three drugs—telaprevir, peginterferon, and ribavirin—in 70 adults with both HIV and hepatitis C who had not been helped by standard treatment before. The goal was to see if this triple therapy could clear the hepatitis C virus from the b…

This study tested two statin drugs, rosuvastatin and pravastatin, in 86 people with HIV who also had high cholesterol. The goal was to see which drug lowered LDL (bad) cholesterol better and was safer when taken with HIV medications. Participants took one of the two statins for 4…

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This phase 3 trial tested whether people with HIV whose virus is already suppressed can safely switch to a new two-drug pill (doravirine/islatravir) instead of staying on their current three-drug regimen (BIC/FTC/TAF). About 643 participants were randomly assigned to either switc…

This study tested two different drug combinations for people with HIV whose first treatment stopped working. 558 participants received either standard second-line drugs plus a newer integrase inhibitor (raltegravir) or the standard second-line drugs alone. The main goal was to se…

This study tested a program for 160 HIV-positive fisherfolk in Uganda who were heavy drinkers and struggling to stick with their HIV medication. The program combined individual and group counseling with help opening savings accounts and building social support. The goal was to re…

This study tested a smartphone app called LetSync designed to help Black men who have sex with men and their partners stay engaged in HIV care and take their medications as prescribed. About 144 participants (80 couples) used the app for up to 14 months. The researchers measured …

This early-stage trial tested a therapeutic DNA vaccine called ICVAX in 45 people with HIV who were already stable on antiretroviral therapy (ART). The goal was to see if the vaccine is safe and whether it can boost the immune system to better control the virus. Participants rece…

This completed study tested a behavioral program called WeCare for men who have sex with men (MSM) in South Africa. The program included individual sessions to identify problems and create action plans, plus group sessions for social support and coping with stigma. The goal was t…

This study tested whether a weekly injection of PRO 140 (Leronlimab) could keep HIV under control in people whose virus was already suppressed by daily pills. Over 500 participants switched from their regular medication to the shot alone for 48 weeks. The goal was to see how many…

This study tested a new combination of three HIV drugs (dolutegravir, emtricitabine, and tenofovir alafenamide) in 53 children aged 28 days to 10 years in Africa. The goal was to find a dose that gives enough medicine in the blood and is safe. If it works, this could lead to a si…

This study tested a low-cost tool to help health workers in Mozambique better diagnose and manage high blood pressure in people with HIV. The tool uses cycles of evaluation and improvement to streamline care. Researchers worked with 18 health facilities to see if this approach co…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, some living with HIV and some without. The goal was to see if the vaccine is safe and produces an immune response in these children. The trial has been c…

This study tested a smartphone app called START to help men with HIV who use stimulants like methamphetamine take their medication regularly. The goal was to lower their viral load and improve health. The app provided support and reminders, and the study measured how well it work…

This completed Phase 3 study tested whether switching to a once-daily combination pill (doravirine/islatravir) works as well as staying on standard HIV therapy. 672 adults with HIV whose virus was already suppressed took part. Results showed the new pill kept the virus under cont…

This study tested a type of talk therapy (CETA) in 399 women in South Africa who have HIV, experienced intimate partner violence, and had trouble keeping the virus under control. The goal was to see if the therapy could help more women achieve an undetectable viral load and reduc…

This study looked at 33 adults with well-controlled HIV who switched from a monthly injectable treatment (CAB+RPV) to a daily oral pill (B/F/TAF). The main goal was to check if the switch was safe, especially for those who couldn't or didn't want to continue injections. Over 12 w…

This study tested whether a mobile care van linked to a needle exchange program could improve HIV prevention and treatment for people who inject drugs. 720 participants received services like HIV testing, treatment, and risk reduction through the van. The goal was to see if this …

This study tested the safety and dosing of long-acting injectable HIV medications (cabotegravir and rilpivirine) in 168 children and adolescents whose HIV was already well-controlled with daily pills. Participants first took oral versions to check tolerance, then switched to shot…

This study looked at whether the HPV vaccine can help prevent high-grade cervical lesions (precancerous growths) in women living with HIV who were already being treated for HPV. About 536 women took part, receiving either the HPV vaccine or a placebo. The goal was to see if the v…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested the HIV medication Genvoya (a single daily pill) in 129 teenagers and children with HIV. The goal was to check how the drug is processed in the body, confirm the right dose, and see if it is safe. Participants included teens new to HIV treatment and children who…

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This study tested whether people with HIV who have a low viral reservoir can safely switch from a three-drug regimen to a two-drug regimen (Truvada alone) while keeping the virus under control. The goal is to reduce long-term side effects and treatment costs. The trial involved 2…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This study compared two different HIV drug combinations in 447 people with advanced HIV (late presenters). One group received a protease inhibitor combo (Symtuza), the other an integrase inhibitor combo (Biktarvy). The goal was to see which works better and has fewer side effects…

This study tested a program called iSTRIVE for 42 adults with HIV who also use opioids or stimulants and were not well engaged in HIV care. The program combined emotion regulation and communication skills training with video check-ins and small rewards to encourage daily HIV medi…

This pilot study tested whether screening pregnant women with HIV for their risk of dropping out of care, then offering tailored support (counseling sessions in person or by phone), could help them stay in treatment and keep the virus under control. The study involved 120 women i…

This study tested whether training healthcare teams to share tasks can help people living with HIV better control their high blood pressure. It involved 960 adults across 30 clinics. The approach included measuring blood pressure, providing lifestyle advice, and starting medicati…

This early-stage study tested a new gene therapy in 2 HIV-positive people with high-risk lymphoma. The therapy involved taking their own stem cells and immune cells, adding a gene to block HIV, and giving them back after chemotherapy. The main goal was to see if the procedure was…

This study tested three football-based programs for teen girls in Zambia to improve HIV testing, birth control use, and mental health. Over 2,100 girls from 32 schools took part. The programs aimed to make it easier for girls to get sexual health services and stick with HIV treat…

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This study tested a 4-session program called PARTNER for young men who have sex with men (ages 18-29) and are in a relationship. The program uses motivational interviewing and video exercises to improve communication about drug use, PrEP (HIV prevention pills), and safer sex. 196…

This pilot study tested a new urine test that measures tenofovir levels to see how well HIV-negative women are taking their daily PrEP medication. Researchers provided real-time feedback based on the test results, along with standard counseling, to 100 women. The goal was to see …

This early-stage trial tested a therapeutic HIV vaccine made from each patient's own white blood cells. The goal was to see if it is safe and can boost the immune system to better control HIV. Forty adults on stable HIV treatment took part, receiving either a vaccine loaded with …

This study tested a program called HOLA (Happy Older Latinos are Active) in 30 Latino adults aged 50+ living with HIV. The program included one-on-one sessions with a community health worker, group walks three times a week, and planning pleasant activities. The goal was to see if…

This study tested a program where people living with HIV who use stimulants (like methamphetamine) could earn rewards for staying drug-free and taking their HIV medications. 37 adults took part in a primary care clinic. The goal was to see if this reward system was practical and …

This pilot study tested whether metformin, a common diabetes drug, can reduce blood vessel damage in the brain of people living with HIV who also have metabolic syndrome (a cluster of conditions like high blood pressure and cholesterol). The study enrolled 30 adults in South Afri…

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The goal was to see if the new pill can control HIV just as well as the current standard treatment. The study measure…

This completed Phase 2a trial tested two experimental oral drugs, VH4004280 and VH4011499, in 44 adults with HIV who had never taken antiretroviral therapy. The goal was to see how well these capsid inhibitors could lower the amount of virus in the blood over 10 days. The study a…

This study tested a program where Black and Hispanic young adults (ages 18-29) with HIV used video calls to talk with trained peer health coaches. The goal was to help them take their HIV medication regularly and lower the amount of virus in their blood. The program included eigh…

This study tested a program that pairs peer support with a mobile app to help Hispanic and Black people with HIV stay on treatment. 309 participants were randomly assigned to the program or standard care. The goal was to see if the program helps more people achieve an undetectabl…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This study tested a short video shown in HIV clinic waiting rooms to encourage patients to start and stick with their HIV medications, stay in care, and protect their partners. Over 4,000 patients from clinics serving mostly African American and Hispanic communities took part. Th…

This completed Phase 4 trial tested a herbal supplement called AntiCov-220 in 82 people with underlying health conditions, including HIV and cancer. The goal was to see if it could prevent and treat COVID-19 by boosting the immune system and fighting the virus. The study compared…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

This study looked at whether the HIV drug dolutegravir is safe and effective in pregnant women who have not yet been treated for HIV. Sixty women in late pregnancy were randomly assigned to receive either dolutegravir or standard HIV medicines. The goal was to measure drug levels…

This study tested whether taking capsules containing healthy donor stool (fecal microbiota transplantation, or FMT) can reduce gut inflammation in people with HIV who are on antiretroviral therapy (ART) but have a low CD4/CD8 ratio. Twenty participants were randomly assigned to r…

Researchers are studying whether a point-of-care nucleic acid test can diagnose HIV faster than standard lab testing and help people get into care or prevention services sooner. The trial enrolls adults at a Seattle HIV clinic, including people living with HIV and those seeking t…

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This pilot study tested whether low-dose CT scans can help find lung cancer early in HIV-positive people who are heavy smokers. Researchers scanned 450 participants to see how many had lung cancer and what types were found. The goal was to learn if this screening method is useful…

This study tested whether using augmented reality (AR) on a smartphone can help men who have sex with men perform HIV self-tests better than using paper instructions. 349 participants in Hong Kong were randomly assigned to use either AR guidance or standard instruction sheets. Re…

This study tested a new rapid HIV test for infants in Zambia that gives results in under an hour, compared to standard lab tests that take weeks. Researchers wanted to see if faster diagnosis would lead to more babies starting treatment sooner. Over 1,600 HIV-exposed infants were…

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

Researchers are testing a field-based sexual health program for people recently exposed to HIV who were notified by New York City's partner services program. The program adds four services to standard contact tracing: HIV and STI testing in the field, same-day start of HIV preven…

Researchers follow more than 1,200 HIV-positive pregnant and postpartum women in Kigali, Rwanda, who receive standard HIV care through prevention of mother-to-child transmission programs. The study tracks whether their babies remain HIV-free through 18 to 24 months of age while m…

This trial tests whether mobile phone communication helps HIV-positive pregnant women in Kenya complete the steps that prevent passing HIV to their babies. Twenty-six health facilities are assigned to either standard care or standard care plus phone-based support for mothers, mal…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

Researchers are testing two lab-made antibodies, CAP256V2LS and VRC07-523LS, given as shots under the skin to young women who do not have HIV. The phase II trial enrolls about 990 women aged 18 to 30 in Zambia and nearby countries. It measures whether the shots cause serious reac…

Researchers at George Washington University are testing a program called Juntas Adelante to see if it helps Latina transgender women in the Washington DC area learn about and use HIV prevention medicines. The program includes five short online videos and up to two virtual coachin…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study is testing a computer-based program called MES-PrEP to help young transgender women in Thailand start and stick with HIV pre-exposure prophylaxis (PrEP). The program provides personalized feedback and information based on each person's confidence and motivation. Resear…

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

This trial tests a strategy called expedited partner therapy (EPT) for men who have sex with men in Peru. When a participant is diagnosed with gonorrhea or chlamydia, they receive antibiotic packets to give to their recent sexual partners, so those partners can get treated withou…

This study tests whether offering a long-acting injectable HIV prevention drug called cabotegravir (CAB-LA) as one of several options in a person-centered 'dynamic choice' model can increase prevention coverage and reduce new HIV infections compared to standard care. The trial en…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults from an STI clinic in Lilongwe, Malawi, will either get the program or usual care. The goal is to see if the program reduces heavy drinkin…

This early trial tests a new long-acting injectable combination of three antiretroviral drugs in healthy adults without HIV. The goal is to see how the body absorbs and clears the medication and whether it is safe. If the approach works, it could lead to a platform for long-actin…

This trial tests whether a community-based program can help reduce HIV infections among people who move into rural Ugandan communities. Migrants often have higher HIV rates but are less likely to use prevention and care services. The program, called WIN, trains community voluntee…

This study tests whether a single counseling session aimed at reducing stigma can help Black men who have sex with men and use substances stay on PrEP, a daily pill that prevents HIV. Participants receive the counseling and are monitored for PrEP adherence through biological test…

This study tested a simple checklist and peer coaching program for people who inject drugs and are hospitalized with serious infections. The goal was to see if these tools could help start HIV prevention medication (PrEP) and addiction treatment. Sixty HIV-negative adults with op…

This study looks at whether US women at risk for HIV can and will take Truvada, a daily pill that prevents HIV infection. Researchers will measure how well women stick to the pill regimen over 24 weeks and explore their attitudes toward this prevention method. The goal is to see …

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This trial tests a tablet-based decision support tool designed to help women learn about their HIV risk and prevention options, including PrEP. Women aged 18-45 who are not living with HIV will be randomly assigned to use the tool before a clinic visit or to receive standard coun…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study tests whether giving HIV prevention pills (PrEP) on a medical van is a good way to reach people who inject drugs and are at high risk for HIV. The researchers will enroll 20 adults who use drugs or are sexually active and see how many start and stay on PrEP. The goal i…

This study tests a program called Start the Conversation, designed to help Black cisgender women learn about and start taking PrEP—a daily pill that prevents HIV. The program includes training for gynecology residents to discuss PrEP with patients, plus a social media campaign. R…

This study tested a communication tool to help women in rural Alabama learn about PrEP (a daily pill that prevents HIV). 67 HIV-negative women at risk for HIV took part. The goal was to see if the tool helped more women get referred to and start PrEP.

This study expands on a previous mobile van HIV/STI testing program for men who have sex with men (MSM) in online spaces. Researchers will add a peer health navigator to help participants get PrEP or HIV care after testing. The study will compare this navigator approach to a refe…

This study tests a counseling program called ACTPrEP, designed to help young Black men who have sex with men (ages 18-34) start and continue taking PrEP, a daily pill that prevents HIV. The program uses acceptance and commitment therapy to address thoughts and feelings that might…

This study tested a mobile app called eSTEP designed to help men who have sex with men and transgender women at high risk for HIV start and continue taking PrEP, a daily pill or injection that prevents HIV. 113 participants were randomly assigned to use the app plus usual care or…

This completed trial in South Africa tested four support strategies—case management, food vouchers, peer buddies, and community PrEP pick-up points—to help female sex workers and young women stay on PrEP, a daily pill that prevents HIV. 304 participants were randomly assigned to …

This study looks at how often cisgender women in Kenya need to take the HIV prevention pill Truvada (TDF-FTC) to keep protective drug levels in their blood. Participants are randomly assigned to take 2, 4, or 7 doses per week for up to 16 weeks, and their drug levels are measured…

This study tests whether a proven HIV prevention education program can be delivered through Facebook to reach high-risk rural women in Appalachia. Participants are women leaving jail who have a history of drug use and risky sexual behavior. The goal is to see if social media can …

This study tested whether a couples-focused counseling and testing program could help prevent HIV and improve care. 544 couples from rural South Africa took part. The goal was to see if this approach increases viral suppression and engagement in HIV care.

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This study tested four practical strategies—training providers, educating patients, improving electronic health records, and offering patient navigation—to increase use of HIV prevention pills (PrEP) among Black women. Over 700 women from 12 community clinics in the Midwest and S…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This completed study tested a van-based program in Baltimore that offered drug checking and HIV prevention medication (PrEP) to people who use drugs. Nearly 500 participants were recruited to see if the program helped them start or stay on PrEP and reduce risky behaviors. The goa…

This study evaluated a program called PALMS that uses live movement and sound to teach HIV prevention to high-risk minority male teens aged 12-18 in juvenile justice or drug treatment centers. The goal was to see if the program reduces risky sexual behaviors and encourages HIV te…

This study tested a program called PARTI to help gay and bisexual men who use stimulants (like meth or cocaine) take their daily HIV prevention pill (PrEP) consistently. The program combined positive affect skills training with a smartphone-based reward system for taking PrEP. Re…

This large study tested an experimental HIV vaccine in over 5,400 healthy South African adults at risk of HIV. The vaccine was designed to teach the immune system to fight HIV. Unfortunately, the vaccine did not prevent HIV infection, and the trial was stopped early. The results …

This study looked at different ways to help young women in South Africa, ages 18-25, take their daily HIV prevention pill (PrEP) consistently. The goal was to find the best support strategies to keep them protected from HIV. 360 women took part in the study, which tested a step-b…

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP (a daily pill to prevent HIV). 118 participants joined the pilot study. The program provided information, motivation, and skills to encourage HIV testing and PrEP use. T…

This study tested a program to help Latino men who have sex with men get access to PrEP (HIV prevention pills), HIV testing, and mental health services. The program included one-on-one outreach sessions and a website with stories from other Latino men. The goal was to see if this…

This study looked at whether men who have sex with men (MSM) in Burkina Faso, Côte d'Ivoire, Mali, and Togo would accept and use PrEP (a daily or on-demand pill) to prevent HIV. Over 600 HIV-negative men at high risk took part, receiving regular check-ups, STI testing, and suppor…

This study tested a special program called 'Estoy PrEParado' designed to help Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. The program provided information, motivation, and skills tailored to this community. Researchers enrolled 105 particip…

This study tested whether a quarterly HIV prevention program is practical and helpful for men who have sex with men in four African countries. Over 800 men received regular check-ups, STI testing and treatment, counseling, and condoms. The goal was to see if this approach could l…

This large study in South Africa tested whether offering HIV treatment to everyone right after diagnosis, instead of waiting until their immune system weakened, could reduce new HIV infections across entire communities. Over 28,000 people from 22 communities took part. The idea i…

This study tested whether a community-based program offering flexible HIV prevention and treatment options could lower the number of new HIV infections. Over 80,000 people aged 15 and older in East African communities took part. The approach focused on delivering the right care t…

This study tested whether a simpler HIV drug combination (lopinavir/ritonavir alone) could safely prevent mothers from passing HIV to their babies during pregnancy, compared to the standard three-drug combo. About 105 pregnant women with well-controlled HIV took part. The goal wa…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested whether training siblings to talk about HIV PrEP helps Latino men who have sex with men start taking it. 288 participants were split into two groups: one where siblings learned to discuss PrEP, and another where siblings discussed vaccines instead. The goal was …

This study tested a smartphone app designed to help Black women in the southern U.S. learn about and access HIV prevention tools, like PrEP, and other sexual health resources. Fifty-six women used the app or received standard information. The goal was to see if the app was easy t…

This study tested two strategies to encourage HIV prevention pill use among adults who visit or work at drinking venues in Kenya and Uganda. Over 9,000 people took part. One approach focused only on HIV testing, while the other offered broader health screenings. The goal was to s…

This study tested two HIV prevention programs for African immigrant women: one-on-one counseling (Dada Kwa Dada) and group sessions (DADA). The goal was to see which approach increases condom use and PrEP uptake. 149 HIV-negative women from the Boston and New York areas took part…

This study tested a program called Manas por Manas to help transgender women in São Paulo, Brazil, overcome stigma and access HIV testing and PrEP (a daily pill that prevents HIV). The program included group sessions led by peers and one-on-one support. Researchers compared HIV t…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested three different daily doses of the HIV prevention pill PrEP in 54 pregnant women in Sub-Saharan Africa. The goal was to find the dose that gives the best protection without harming the mother or baby. Researchers measured drug levels in the blood and tracked any…

This study tested a combination HIV prevention approach for 120 men in Kisumu, Kenya, who had recently exchanged sex for money or goods. Participants took daily PrEP pills and received real-time feedback from a urine test, HIV self-test kits, and text reminders. The goal was to s…

This study tested a new way to help young men who have sex with men (ages 18-30) take their daily HIV prevention pills consistently. Participants provided a urine sample that was tested right away for the HIV prevention drug, and then received a short counseling session based on …

This completed phase 4 study looked at how to best offer cabotegravir PrEP (a long-acting injection and tablets) to Black cisgender and transgender women in the US who do not have HIV. About 370 women took part, and researchers measured how well different delivery strategies work…

This study tested an experimental oral drug called MK-8527, taken once a month, to see if it is safe and how it works in the body for HIV prevention. 352 HIV-negative adults at low risk for infection participated. The main goals were to check for side effects and measure drug lev…

This study tested a program to help women get information and access to PrEP, a daily pill that prevents HIV. The program included training for clinic staff, educational materials, and a navigator to guide patients. About 745 women receiving care at the clinic took part, and rese…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This completed study looked at how to best offer cabotegravir, an HIV prevention shot, in US clinics. About 287 men and transgender men at risk for HIV took part. Researchers compared two ways of rolling out the shot to see which worked better in busy and less busy clinics.

This study tested whether a personal helper (a systems navigator) could help heterosexual men in Malawi keep taking HIV prevention medication (PrEP). 199 men who were getting care for sexually transmitted infections took part. The navigator provided support and reminders to help …

This pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …

This study tested two strategies to prevent HIV among young couples (ages 18-30) in Cape Town who use alcohol or drugs. One strategy was a community workshop to reduce stigma around HIV and drug use. The other was a couples program that provided HIV testing and counseling to help…

This early-stage study tested a vaginal ring that slowly releases the HIV drug tenofovir over 90 days. Researchers wanted to see if the ring is safe and delivers enough drug to the body. 49 healthy women took part, and the study measured drug levels in blood, vaginal fluid, and t…

This study tested different ways to deliver HIV testing and counseling to young men who have sex with men (ages 15-24) and their partners. The goal was to see which approach helps couples communicate better and reduce risky behaviors like condomless sex with casual partners. 71 c…

This study tested a new way to help young women in Kenya start PrEP, a daily pill that prevents HIV. Young women already taking PrEP were trained to refer their friends and give them HIV self-test kits. The goal was to see if this peer-led approach could increase PrEP use among t…

This study tested whether barbershops in the Kalangala islands of Uganda could be a good place to offer HIV prevention services to heterosexual men. Researchers enrolled 250 men and had barbers provide HIV education, hand out self-test kits, and share information about prevention…

This study tested whether home visits by male-female pairs of health workers could encourage pregnant women and their male partners to get tested for HIV together. About 1,600 couples in Kenya took part. The goal was to increase couple HIV testing and prevent transmission from mo…

This study tested whether offering HIV PrEP (a daily pill that prevents HIV) through telehealth visits could help more Black and Latino men who have sex with men start and stay on the medication. Researchers enrolled 75 HIV-negative men and provided PrEP care remotely. The goal w…

This study tested whether a registered nurse could help women at risk for HIV learn about and start PrEP (a daily pill that prevents HIV) during OB/GYN visits. 440 women were randomly assigned to either standard care or a nurse-led program that included counseling and lab tests. …

This study tested a program to help healthcare providers prescribe HIV PrEP (pre-exposure prophylaxis) more effectively. The program included a web-based tool and a coordinator to support doctors. Ten clinics in San Francisco participated. The goal was to see if the program incre…

This completed trial tested a digital program called LuvHub for male couples. The program includes modules on HIV/STI prevention, communication, and relationship goals. Over 16 months, 778 couples used the tool to create personalized prevention plans and agreements. The study mea…

This study looked at whether a three-drug HIV pill called Delstrigo can prevent HIV infection when taken for 28 days after a possible exposure. About 400 adults who came to the emergency room after a potential HIV contact took the pill daily. Researchers tracked how many complete…

This large phase 3 trial tested whether a daily statin (pitavastatin) can reduce the risk of heart attacks, strokes, and other cardiovascular events in adults with HIV who are on antiretroviral therapy. Over 7,700 participants from multiple countries took either the statin or a p…

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This study tested a resilience-building program called RISE+ in 106 people over 50 living with HIV. Participants watched videos and did activities to improve coping skills, optimism, and social connections. The goal was to see if the program helps them handle daily stress better …

This pilot study tests a brief intervention for people with HIV who take five or more medications and drink alcohol. A clinical pharmacist will have one-on-one conversations using motivational interviewing to discuss how alcohol can interact with medications and worsen symptoms. …

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This pilot study tests a digital decision aid designed for people who have experienced sexual assault and are considering HIV post-exposure prophylaxis (PEP). The tool helps patients and providers weigh risk, effectiveness, side effects, and personal priorities together. Research…

This study explores whether combining mindfulness meditation with transcutaneous nerve stimulation (TENS) can reduce foot pain in people living with HIV who have peripheral neuropathy. Participants use a home TENS device and practice guided meditation over several weeks. The goal…

This study tested a tablet-based app called COPPEhR designed to help older adults with HIV (age 50+) connect with others, access resources, and reduce loneliness. Sixty-eight participants either got the app or a tablet without it. The main goal was to see if the app was easy to u…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study tested a training program for people living with HIV to help them become more active in managing their health. The program was delivered by psychologists and aimed to improve treatment adherence, quality of life, and emotional well-being. 75 participants took part in t…

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study looked at whether a 16-week program of aerobic and resistance exercise could improve physical function and reduce inflammation in HIV-infected veterans aged 50 and older. Thirty-three participants completed the program, and researchers measured changes in heart and mus…

This pilot study tested a short form of Acceptance and Commitment Therapy (ACT) in 49 people living with HIV who were hazardous drinkers. The therapy uses mindfulness and values-based action to reduce drinking and improve medication adherence. Researchers measured drinking days, …

This study looked at whether Tai Chi, a gentle mind-body exercise, can help adults over 45 living with both HIV and chronic pain. Researchers tested the program with 36 participants to see if it was practical and liked by patients. The goal was to find a non-drug way to reduce pa…

This study tested two programs to reduce the shame and stigma that adolescents with HIV often face. 89 teens aged 10-14 in Uganda took part in either group therapy, family sessions, or standard care. The goal was to see if these programs could help them feel better about themselv…

This study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…

This study tested whether Eye Movement Desensitization and Reprocessing (EMDR) therapy, a proven treatment for trauma, can help people recently diagnosed with HIV. Forty participants were split into two groups: one received standard medical care plus weekly EMDR for up to 6 month…

This study tested whether two short training sessions on resilience and medication adherence could improve the quality of life for 130 HIV-positive mothers and their children in China. The training focused on coping skills, stigma management, and communication. Researchers measur…

This study tested an 8-week group program that uses Buddhist principles and cognitive behavioral therapy to help people with HIV in Myanmar cope with stigma. Nineteen participants joined group discussions led by a trained facilitator. The goal was to see if the program could redu…

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults (50+) living with HIV. The program teaches skills to manage stress related to aging and HIV, and encourages healthy habits like physic…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

Researchers are collecting health records from young people with HIV in ten African countries who have taken the drugs darunavir, etravirine, or both. The study follows their demographics, clinical and laboratory profiles, and HIV drug resistance over time. The goal is to underst…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

Researchers in Ethiopia are studying how HIV spreads among people with different treatment histories. They compare newly diagnosed individuals who have never taken antiretroviral therapy with those on therapy who have not achieved viral suppression, and with those who are virally…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looks at how cumulative stress and trauma influence alcohol use and HIV self-management in young people living with HIV, ages 18 to 29. Researchers will track drinking patterns and viral load to identify modifiable targets for future interventions. The goal is to find …

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This completed study tested whether analyzing social media messages (like WhatsApp and Instagram) from 400 young women aged 18-24 in Kisumu, Kenya could help identify those at risk for HIV. Researchers used AI to look at language patterns and compared them to standard HIV risk sc…

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

This study will check 300 people living with HIV for oral HPV infection and mouth lesions using a simple swish-and-spit sample. Researchers will compare those who test positive and negative, and look at factors like age, sex, tobacco use, and HIV lab results to see what might pre…

This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. …

This study asks whether common antacids or multivitamins change how the body absorbs raltegravir, an HIV medication. Healthy adult volunteers will take raltegravir alone and alongside different antacids or a multivitamin, with blood samples measuring drug levels over 12 hours. Th…

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This trial asks whether a single tablet combining three HIV medications (ACC017, emtricitabine, and tenofovir alafenamide) is absorbed by the body just as well as taking the same drugs separately. Healthy adult volunteers will receive both versions in a random order under fasting…

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This completed study tested an online program designed to encourage HIV and syphilis testing, condom use, and PrEP uptake among young American Indian men and gay/bisexual men in rural Oklahoma. Researchers worked with community advisors to tailor health materials to local culture…

This study investigates whether telling others about an HIV diagnosis affects how consistently people take their HIV medications. Researchers believe that disclosure might lead to social support, which could improve adherence. The study follows 120 people with HIV who are already…

This study examines how consistently pregnant women with HIV take their antiretroviral medication during pregnancy and after childbirth. Using electronic monitoring devices, pill counts, and interviews, researchers track changes in adherence and record the barriers and facilitato…

This study tests a program to help caregivers tell children (ages 7-18) their HIV status in a supportive way. It involves 747 children and their caregivers across 12 clinics in Ghana. The goal is to see if this approach improves medication adherence and overall health.

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This early-stage trial tested whether a combination of two HIV-1 activators is safe for people with HIV subtype B who are on standard antiretroviral therapy and have undetectable virus levels. Nine men participated, and the study focused on tracking side effects. The goal was to …

This study looked at 777 people with HIV in Brazil who failed their first treatment with tenofovir, lamivudine, and dolutegravir. Researchers wanted to understand what types of drug resistance and virus subtypes were involved. The goal is to improve treatment choices for people i…

This study tested whether giving HIV self-test kits to HIV-negative pregnant women for their male partners would increase the number of men who get tested for HIV. Two hundred women in Malawi were split into two groups: one where partners got a clinic referral slip, and another w…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This early-stage trial tested a single injection of JL18008, a lab-made protein designed to boost immune cells, in 40 healthy adults. The main goal was to check safety and how the body handles the drug. Researchers also measured changes in immune cell counts over 56 days. This is…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study looked at how people living with HIV in rural Uganda experience stigma, including feelings of shame, loss of self-respect, and mistreatment by others. Researchers surveyed 180 adults to understand these experiences better. The goal was to gather information, not to pro…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at how not having enough healthy food (food insecurity) can lead to insulin resistance in people living with HIV. Researchers tested a community-based "food as medicine" program that provided healthy food and taught cooking and self-care skills. The goal was to …

This study tested a more concentrated version of the long-acting HIV drug cabotegravir in 138 healthy adults. Researchers gave the injection in different ways (into muscle or under the skin) to see how the body processes it and to check for side effects. The goal was to gather sa…

This study tested a streamlined HIV care approach for pregnant and postpartum women and their infants at a hospital in Kenya. The goal was to see if offering simpler, more flexible services could reduce clinic wait times and keep mothers and babies healthy. Researchers tracked vi…

This study examined how veterans with HIV use My HealtheVet (MHV), an online health portal, to manage their condition. Researchers reviewed medical records and interviewed 123 veterans to understand the impact of MHV on HIV care. The goal was to develop and test an intervention t…

This first-in-human study tested a single dose of LP-98 injection in 36 healthy adults to see if it is safe and how the body processes it. Participants received either LP-98 or a placebo by injection under the skin or into a vein. The study is complete, but it only looked at safe…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers used a special blood test to measure how well participants were taking their pills and whether that predicted if the virus stayed under control. The goal was to see if this test could …

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This study tested a 4-session program that helps HIV+ Asian Pacific American men manage their health with support from family. Nineteen men took part to see if the program was acceptable and practical. The goal was to learn if this approach could help this community better manage…

This completed study tested a small-group discussion program called SISTA-P for Black women at high risk for HIV. The program covered self-care, HIV and PrEP education, and assertiveness skills. Researchers enrolled 23 women in Washington D.C., Atlanta, and New Orleans to see if …

This study tested simple toolkits to encourage women living with HIV in Ghana to collect their own samples for HPV testing, which can help prevent cervical cancer. About 108 women took part, and the researchers checked if they completed and returned the self-sampling kit or got a…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study investigates why the gut immune barrier remains damaged in people with HIV even after successful antiretroviral therapy. Researchers collected blood and intestinal biopsies from 80 participants to measure immune cells and inflammation. The goal is to understand why the…

This study looked at 167 men who have sex with men and are on HIV treatment with undetectable virus in their blood. Researchers took blood and semen samples to see if the virus could still be found in semen. The goal was to understand if there is still a risk of passing HIV to ot…

This study looked at a genetic variation in the TLR7 gene, which helps the immune system detect viruses like HIV-1. Researchers compared 90 women—some with HIV and some without—to see if this gene difference is more common in infected women. The goal was to understand how this va…

This study looks at why HIV remains in the body even when standard treatment keeps virus levels undetectable in the blood. Researchers will take small tissue samples from the gut and blood of 30 HIV-positive adults on effective therapy. The goal is to understand how the virus per…

This early-stage study tested whether a working memory training program is practical and acceptable for people aging with HIV. Researchers enrolled 100 participants aged 50-85, including those with and without HIV, to see if the training could improve memory and thinking skills. …

This study looked at how pregnancy changes the levels of the HIV drug doravirine in the blood. Seven pregnant women living with HIV took a single dose of doravirine during their second and third trimesters, and again after giving birth. The goal was to find the right dose for pre…

This study tested a 5-month group program called Sweekar to reduce stigma and increase HIV testing and medication adherence among transgender and gender-diverse adults in Nepal. 31 participants joined group sessions to address social stigma and HIV prevention needs. The study mea…

This study looked at how five common HIV drugs enter breast milk in 20 healthy women who were finishing breastfeeding. The goal was to find out if the drug levels could be too high (risking infant side effects) or too low (risking drug resistance if the baby gets HIV). Participan…

This study looked at whether it is possible and practical to offer rapid HIV testing to men who have sex with men (MSM) in community settings, rather than only at clinics. Researchers worked with teams in France and Canada to test this approach with 357 participants. The goal was…

This study looked at 20 men with HIV who were stable on a common drug combination. Researchers took samples of blood, lymph nodes, rectal tissue, fat, and semen to measure how much of the drugs reached these areas. The goal was to understand why HIV can still hide in some tissues…

This study surveyed 596 people in France who were newly diagnosed with HIV. The goal was to find out why they did not use pre-exposure prophylaxis (PrEP), a medicine that prevents HIV infection. By understanding these missed opportunities, researchers hope to improve how PrEP is …

This study looked at how a single dose of methamphetamine affects the HIV virus in people who are already on effective HIV treatment. Fourteen HIV-positive adults with no history of meth use took part. The goal was to see if meth causes the virus to become more active and increas…

This completed Phase 1 trial from Johns Hopkins University enrolled 13 transgender women to see how the HIV prevention drug Truvada interacts with feminizing hormones like estrogen. Participants took Truvada alone and then with added hormones or a testosterone blocker. The goal w…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This completed study examined blood samples from 65 children aged 0 to 18 who were taking common HIV medications. The goal was to create computer models that show how these drugs behave in children, helping doctors adjust doses for each child's age, weight, and other factors. The…

This study followed 450 transgender people (300 HIV-negative and 150 living with HIV) from community health centers in Thailand, Vietnam, and the Philippines for 24 months. Researchers tracked new HIV infections, mental health, and social factors like stigma and violence using su…

This study looked at how many hospital patients have undiagnosed HIV. Researchers offered a rapid finger-prick HIV test to 300 patients who had certain medical conditions or behaviors that increase HIV risk. The goal was to find hidden infections and understand how common they ar…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This study follows 179 volunteers who received an experimental HIV vaccine about 10 years ago. Researchers want to see if the vaccine's immune effects and virus control have lasted. No new treatment is given; this is just an observation to gather long-term data.

This study tested whether a nurse-led education program could improve women's knowledge about HPV and its effects on health. 84 women aged 30-49 with active sexual lives took part. The program aimed to help them make informed decisions about their reproductive health.

This study measured how common Mycoplasma genitalium (MG) infection is among HIV-positive men in Hong Kong and checked for antibiotic resistance. Researchers collected samples from 573 men attending an HIV clinic. The goal was to understand the spread of MG and whether common ant…

This study looked at whether giving extra training and support to staff at Boys and Girls Clubs helps them run teen sexual health programs better. About 900 youth aged 10-14 took part. The goal was to see if this support leads to better attitudes and behaviors around sex, pregnan…

This study looked at whether an experimental antibody called VRC01 could help people with HIV control the virus after they stop taking their daily HIV medication. Thirteen people who had received VRC01 or a placebo in an earlier study and later got HIV took part. They paused thei…

This study looked at health records of over 2,000 people with HIV from racial and ethnic minority groups to see if seeing a heart specialist (cardiologist) helps prevent heart disease. Researchers tracked who visited a cardiologist and for how long, up to 5 years. The goal is to …

This study tested whether a smartphone app called eWrapper could help young adults with HIV wear an alcohol biosensor for 30 days. Sixty-six participants in Florida used the app, which offered rewards and personalized feedback to encourage sensor use. The goal was to see if these…

This pilot study tested a three-session couple-based program for male couples where one partner has HIV and the other does not. The program focused on seeing HIV as a shared challenge, improving communication, and supporting each other. Researchers measured changes in quality of …

This study asked 36 women about their opinions and use of vaginal products designed to prevent HIV and other sexually transmitted infections. Participants completed questionnaires about their sexual behavior and how often they would use such products. The goal was to gather insig…

This study tested a reproductive health education program designed for women living with HIV. The program aimed to increase knowledge about reproductive health and encourage healthy behaviors. Sixty women participated, and researchers measured changes in their knowledge and attit…

This study looked at whether people with HIV can receive their long-acting injectable medication at general day hospitals instead of only at specialized HIV clinics. 90 patients who were already prescribed the injections were randomly assigned to one of the two settings. The main…

This study followed about 1,900 pregnant women and their babies for two years to see how HIV and the medication dolutegravir affect weight gain and overall metabolic health. Researchers compared women with HIV to those without, and also looked at differences between women who sta…

This study tested whether a set of strategies—including community teamwork, tech-based training, and peer support—could improve HIV testing and substance use care for people about to be released from jail. Researchers worked with 65 incarcerated individuals in one New York county…

This study developed and tested a digital intervention for pregnant unmarried adolescents aged 15-19 living with HIV in Kenya. The app uses stories and lessons to help them understand stigma, build confidence to disclose their HIV and pregnancy status to family, and seek support.…

This study followed 10 people with HIV and AIDS-related Kaposi sarcoma in Tanzania to see how their quality of life changed during treatment with vincristine and bleomycin. Participants filled out questionnaires about their physical, emotional, social, and daily functioning over …

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at how young men who have sex with men search for information about PrEP (a pill or shot that prevents HIV). About 314 participants browsed a mock Google results page, and researchers tracked which links they clicked and how long they stayed. The goal was to fin…

This study tested two different long-acting versions of the HIV drug cabotegravir in 56 healthy adults. The goal was to see how safe they are and how the body processes them. No treatment was given for HIV; the study simply gathered information to help develop better formulations…

This study looked back at 30 people with HIV who received a special cancer treatment called CAR T-cell therapy for certain blood cancers. Researchers collected information from medical records to see what side effects occurred and how the immune system changed over time. The goal…

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and …

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study followed 200 transgender and non-binary people living with HIV across Europe for 18 months. Researchers collected data from routine blood tests to see how well HIV treatment was working. The goal is to use these findings to create better treatment guidelines and design…

This study tested 350 detainees in Nîmes, France for HIV, hepatitis B, and hepatitis C using rapid diagnostic tests. Many detainees come from areas where these infections are common and often don't know their status. The goal was to find out how many are infected so that care can…

This study tested a training program for family medicine doctors in Alabama to help them talk about HIV and STI prevention with teenage girls and young women. 46 doctors took part and completed surveys before and after training to see if their knowledge and practices changed. The…

This study looked at 16 mothers with HIV who chose to breastfeed while taking antiretroviral medication. Researchers measured drug levels in the mothers' blood and breastmilk, and in the babies' blood, to see how much medicine the infants received. The goal was to gather informat…

This study aimed to understand the barriers to treating high blood pressure in people living with HIV in South Africa and to design a better care program. Researchers gathered input from healthcare workers and patients at nine clinics to create a practical intervention. The goal …

This completed Phase 1 trial studied 16 healthy volunteers to see if the HIV drug dolutegravir affects insulin sensitivity, fat metabolism, and hormone levels. Researchers aim to understand why some HIV patients gain weight while taking this medication. Participants took dolutegr…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study tested whether an online mindfulness program is practical and well-liked by young gay, bisexual, and queer men who are at risk for HIV. About 60 participants were randomly assigned to either the mindfulness program or a control group. The main goal was to see if the pr…

This study looked at over 1,100 people with HIV whose dolutegravir-based treatment stopped working. Researchers collected blood samples to find drug-resistance mutations in the virus. The goal is to understand why some treatments fail and how to better manage HIV in the future.

This study tested a method called public deliberation to improve how researchers get consent from teens for HIV prevention studies. 128 participants from diverse communities discussed ethical conflicts around parental permission versus teen self-consent. The goal was to see if th…

This study tested a program called CJC-TraC, where a nurse case manager helps incarcerated individuals with HIV, hepatitis C, or substance use disorder prepare for release and connect to community healthcare. The program involved up to 4 in-person or telehealth visits before rele…

This study tested a new gender-affirming program called STARS for transgender women who have experienced intimate partner violence. The goal was to see if it could help reduce HIV risk and improve safety. Thirty-seven participants were randomly assigned to either the STARS progra…

This completed study tested a tablet-based screening system for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. Patients who screened positive were offered behavioral treatments like motivational interviewing and cognitive b…

This study followed over 1,300 people with HIV in England and Ireland to understand how ageing affects their health. Researchers compared older HIV-positive adults (over 50) with younger HIV-positive adults and HIV-negative older adults. The goal was to identify common medical is…

This completed study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Participants wore sleep trackers, kept sleep diaries, and underwent pain tests. The goal was to understand if poor sleep drives pain and inflammation, which could ma…

This completed study tested whether using genetic information and measuring drug levels in the blood can help doctors choose the right dose of HIV medications (efavirenz or atazanavir) for each patient. 190 adults starting HIV treatment for the first time took part across four si…

This study tested how acceptable HIV pre-exposure prophylaxis (PrEP) is among men who have sex with men and transgender individuals who agreed to HIV/STI testing through a community-based outreach program, both online and in person. Researchers recruited 209 participants via a ge…

This completed study in France looked at 248 people taking PrEP (a daily pill to prevent HIV) to see how their sexual behaviors and rates of other sexually transmitted infections (STIs) changed over time. Researchers compared those on PrEP for over a year to those on it for less …