Experimental HIV vaccine trimer 4571 tested in small safety trial

NCT ID NCT04985760

Completed ⭐️ VACCINE ⭐️ Sponsor: Madhu Chhanda Choudhary Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage trial tested an experimental HIV vaccine called Trimer 4571 in 32 adults with HIV who were already on effective antiretroviral therapy (ART). The main goal was to check if the vaccine is safe and tolerable, and to see if it helps the immune system produce broadly neutralizing antibodies against HIV. Participants received either a low dose, high dose, or placebo vaccine, and were monitored for side effects and immune responses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trimer 4571 HIV vaccine with alum adjuvant
What this could lead to: If successful, this could help develop a vaccine that trains the immune system to produce broadly neutralizing antibodies against HIV, potentially leading to better HIV control or prevention strategies.
What could go wrong: This is a very early Phase 1 trial with only 32 participants, so results may not apply broadly. The vaccine is still experimental and may not produce the desired immune response or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIV INFECTIONS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

Locations

AIDS Clinical Trials Unit/The Ohio State University

Columbus, Ohio, 43210, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.