Stomach disorder

This study tests whether giving a three-part treatment before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. The treatment combines an immunotherapy drug (tislelizumab) with standard chemotherapy and a short course of ra…

This study tests a new drug called MBX 1416 in 10 people who have low blood sugar episodes after weight loss surgery. Participants receive two injections of the drug, a low dose and a high dose, about two weeks apart. The goal is to see if the drug can raise the lowest blood suga…

This study compared two ways to fix a failed mitral heart valve replacement: a less invasive procedure called valve-in-valve (using a catheter to place a new valve inside the old one) versus repeat open-heart surgery. The trial included 150 adults with severe valve problems. Rese…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This early-phase trial tested a new drug called RO7496353 combined with an immunotherapy (atezolizumab) and sometimes chemotherapy in 102 people with advanced lung, stomach, or pancreatic cancer. The main goal was to check safety and side effects. Researchers also looked at how t…

This study tested two experimental drugs (AK104 and AK117) together, sometimes with chemotherapy, in 128 people with advanced solid tumors. The goal was to see if the combination is safe and can shrink tumors. It focused on patients with stomach, esophageal, or other advanced can…

This study tested a new way to reconnect the stomach and small intestine after removing the lower part of the stomach in people with advanced stomach cancer. The goal was to see if the new stapling method was safe and worked well. One hundred patients took part, and the researche…

This phase 2 trial tested personalized immunotherapy combinations for advanced gastric cancer that had worsened after initial chemotherapy. Researchers matched treatments to tumor genetics: patients with certain genetic features received atezolizumab plus ipatasertib, while other…

This study tested a new drug called MK-1200 in 13 people with advanced solid tumors, including stomach, esophageal, bile duct, and pancreatic cancers. The goal was to find safe doses and see if the drug could shrink tumors. The study is complete, but results are not yet available…

This phase 2 trial tested a combination of radiation, a targeted drug (olaparib), and an immunotherapy (pembrolizumab) in 9 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if this approach could shrink tumors that were not dir…

This phase 2 study tested a combination of two drugs, pembrolizumab and ramucirumab, in 26 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if the combo could shrink tumors or slow the disease. Participants received both drugs …

This phase II trial tested a combination of three treatments: specially engineered natural killer cells (PD-L1 CAR-NK cells), an immunotherapy drug (pembrolizumab), and an immune booster (N-803) in 18 adults with advanced gastric or head and neck cancer that had not responded to …

This phase 3 trial tested whether adding a targeted drug called bemarituzumab to standard chemotherapy helps people with advanced stomach or gastroesophageal junction cancer that has a specific protein (FGFR2b). The study enrolled 547 adults whose cancer could not be removed by s…

This study tested whether adding intravenous (IV) nutrition to standard oral supplements helps patients who had stomach cancer surgery recover better. 55 adults were randomly assigned to get either the combined nutrition or standard care. The main goal was to see if the combo app…

This study tested a new drug called gentuximab combined with the chemotherapy drug paclitaxel in 76 people with advanced stomach or gastroesophageal junction cancer that had worsened after initial treatment. The goal was to find a safe and effective dose and see if the combinatio…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study looked at whether a specific keyhole surgery (Toupet fundoplication) can help people with a hiatal hernia that causes heartburn but doesn't show up on X-rays. 100 adults with this condition had the surgery and were followed to see if their symptoms came back or if they…

This pilot study tested a combination of chemotherapy drugs (FOLFIRINOX plus paclitaxel and carboplatin) along with proton beam radiation before surgery in 25 people with gastroesophageal cancer. The goal was to see if this intense pre-surgery treatment could shrink tumors and be…

This study tested a new oral drug called HMPL-453 tartrate, either alone or combined with chemotherapy or an immunotherapy (toripalimab), in 190 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and see if th…

This study tested a drug called savolitinib in 110 people with advanced stomach or esophagus-stomach junction cancer whose tumors have a specific genetic change (MET gene amplification). The goal was to see if the drug could shrink tumors and how safe it was. Participants receive…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This study tested whether adding the immunotherapy drug spartalizumab to standard chemotherapy (FLOT) helps shrink stomach cancer before surgery and prevent it from coming back. 67 adults with resectable stomach or gastroesophageal junction cancer received the combination before …

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested whether adding a crural repair and gastropexy to standard sleeve gastrectomy reduces acid reflux in people with severe obesity. Fifty patients were randomly assigned to either the standard surgery or the enhanced version. After one year, the group with the extra…

This study tested a new drug called PRL3-ZUMAB in 14 people with advanced solid tumors (like stomach or liver cancer) that stopped responding to standard treatments. The drug was given every two weeks to see if it could shrink tumors or stop them from growing. Researchers also lo…

This study tested a special collagen mesh for hernia repair in 30 patients who were at high risk for complications, such as those with diabetes or infections. The mesh is designed to be absorbed by the body and help tissue heal naturally, avoiding problems linked to permanent syn…

This study tested a mix of three drugs—trastuzumab deruxtecan (a targeted therapy), nivolumab (an immunotherapy), and chemotherapy—in 30 people with untreated HER2-low stomach or gastroesophageal junction cancer. The goal was to first find a safe dose and then see how well it shr…

This early-phase study tested a new treatment using immune cells from cord blood, modified to target a protein called Claudin18.2 found on some cancer cells. Ten adults with advanced stomach or pancreatic cancer who had no other options received these cells to find the safest dos…

This completed study by Pfizer tested a biosimilar (a near-copy) of trastuzumab in 8 people with advanced or recurrent HER2-positive gastric cancer that could not be removed by surgery. The goal was to check safety and how well the drug worked in real-world use. Participants rece…

This study tested whether tracking daily steps with a simple pedometer could help identify cancer patients at high risk of being hospitalized during chemoradiotherapy. 40 adults with head and neck, lung, esophageal, or stomach cancer wore a pedometer and received extra support li…

This small pilot study tested a biological mesh called SurgiMend during laparoscopic hiatal hernia repair in 9 adults. The goal was to see if the mesh helps prevent the hernia from coming back and improves quality of life. Participants were followed for 6 months with X-rays and s…

This early-phase trial tested a combination of two targeted drugs (regorafenib and nivolumab) plus standard chemotherapy in 30 adults with advanced or recurrent stomach, gastroesophageal junction, or esophageal adenocarcinoma that could not be surgically removed. The goal was to …

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This phase 2 trial tested adding the immunotherapy drug durvalumab to a standard chemotherapy regimen (docetaxel, oxaliplatin, S-1) before and after surgery in 68 patients with resectable stomach or gastroesophageal junction cancer. The main goal was to see how many patients had …

This phase 2 trial tests the drug utidelone in 126 people with advanced solid tumors (excluding breast, lung, and colorectal cancers) that have not responded to standard treatments. The study aims to see if the drug can shrink tumors and how safe it is. Participants receive utide…

This phase II study tested whether adding trastuzumab (a targeted therapy) to standard chemotherapy could help people with advanced stomach or gastroesophageal junction cancer. Unlike typical patients, these participants had tumors that tested negative for HER2 in tissue but posi…

This completed Phase 2 trial tested whether a special DNA-based test could predict how well patients with stomach or rectal cancer respond to immunotherapy (tislelizumab) combined with chemotherapy and/or radiation. 189 adults with advanced cancer participated. The goal was to se…

This study tested a new cancer drug called brigimadlin (BI 907828) in 266 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. Brigimadlin is an MDM2 inhibitor tak…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This completed Phase 2 study tested a combination of chemotherapy (FOLFIRI) and radiation with 5-fluorouracil in 63 patients with gastric cancer. The treatment was given either before or after surgery to remove the tumor. The goal was to see if this approach is feasible and less …

This study looked at 20 adults who had weight-loss surgery (sleeve gastrectomy) and also needed hiatal hernia repair. Surgeons used a mesh to strengthen the hernia fix. The goal was to see if this lowers the chance of the hernia coming back. Results suggest mesh repair may help c…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This study tested a new drug called BI 3706674 in 47 adults with advanced stomach or esophageal cancer that had not responded to prior treatment. The drug is a tablet that blocks growth signals in cancer cells. The main goals were to find a safe dose and see if the drug could shr…

This study tested whether a personalized nutrition plan, including extra amino acids, could improve muscle quality and recovery in 40 men undergoing surgery for gastric cancer. Half received standard care, and half received a tailored supplement. The goal was to see if this appro…

This phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy before and after surgery helps people with stomach or gastroesophageal junction cancer. Over 1,000 participants received either pembrolizumab plus chemo or placebo pl…

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This study tested whether adding the drug pembrolizumab to standard chemotherapy helps Chinese adults with stomach or gastroesophageal junction cancer. Participants received the drug combination or a placebo before and after surgery. The goal was to see if the combination improve…

This study tested a combination of two experimental drugs, AK112 and AK117, with or without chemotherapy, in 154 people with advanced solid tumors. The goal was to see if the combo could shrink tumors and control the disease. The trial has finished, and researchers are now lookin…

This phase 2 study tested a combination of two drugs, TAS 102 (Lonsurf) and ramucirumab (Cyramza), in 23 patients with advanced stomach or gastroesophageal junction cancer that had stopped responding to other treatments. The goal was to see if the combo was safe and could help pa…

This study tested whether a longer intestinal bypass during stomach cancer surgery improves diabetes control better than the standard method. It included 94 adults with early-stage gastric cancer and type 2 diabetes. Researchers measured blood sugar and hormone levels one year af…

This large Phase 3 trial tested adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy for people with advanced stomach cancer that cannot be removed by surgery. Over 1,500 participants received either pembrolizumab plus chemo or a placebo plus chemo. The…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This study compared two types of surgery for stomach cancer: laparoscopic (keyhole) and open surgery. The goal was to see if keyhole surgery leads to a shorter hospital stay and fewer complications. The trial included 210 patients with resectable stomach cancer and is now complet…

This study tested whether adding a traditional Chinese herbal formula (Banxiaxiexin decoction) to standard antibiotics can better treat H. pylori infection and related indigestion. 104 adults with both conditions took either the herbal combo or standard therapy for 14 days. The m…

This completed trial compared two surgical techniques for repairing incisional hernias: placing mesh on top of the abdominal muscle (onlay) versus behind it (sublay). 350 adults were randomly assigned to one of the two procedures and followed for three months. The goal was to see…

This early-phase study tested a new drug called SHR-A1811 in 101 people with advanced stomach or colorectal cancers that have a specific protein called HER2. The main goals were to check the drug's safety, find the best dose, and see early signs of tumor shrinkage. Participants h…

This study tested two drugs, olaparib and ramucirumab, in 51 people with advanced stomach or gastroesophageal junction cancer that had spread or could not be removed. The goal was to find the best dose and see how well the combination worked. The trial is complete, and results ma…

This early-phase study tests two experimental drugs, BI 765049 and ezabenlimab, in adults with advanced solid tumors like colorectal, lung, and pancreatic cancer. The main goal is to find the highest safe dose of BI 765049 alone and in combination with ezabenlimab. Participants r…

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This early-phase trial tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, gastric, pancreatic, or ovarian) that had returned or spread despite prior treatments. The drug is designed to help the immune system attack cancer cells that carry a s…

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and nintedanib (a drug that blocks blood vessel growth)—in 196 adults with advanced solid tumors that had worsened after standard treatment. The main goal was to find the safest dose of nint…

This study tested a special stapler during a combined weight-loss and anti-reflux surgery called Nissen Sleeve. It involved 167 people with obesity and GERD. The goal was to see if the surgery reduces acid reflux and if the stapler works safely.

This completed study in Laos tested over 1,200 adults for H. pylori, a stomach bacteria linked to cancer. Those infected received a 14-day course of antibiotics and acid-reducing medication. The study also screened high-risk participants for early signs of stomach cancer. The goa…

This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking …

This study tested an experimental drug called RC88 in 198 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors or slow their growth. The study was completed and looked at sid…

This study tested whether transplanting specific stomach bacteria (probiotics) could relieve symptoms of functional dyspepsia, a common digestive disorder. 74 adults with indigestion but no H. pylori infection received either the probiotic or a placebo. The main goal was to see i…

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omepr…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This early-phase trial tested an experimental drug called ezabenlimab, alone or combined with another drug (BI 754111), in 146 Asian patients with advanced solid tumors. The main goals were to check safety, find the right dose, and see if the combination shrinks tumors in cancers…

This study tested a drug called mizagliflozin in 15 people who had gastric bypass surgery and suffer from dangerously low blood sugar after eating. The goal was to see if the drug could reduce these episodes and improve safety. The trial is now complete, and results will help det…

This early-stage trial tested the safety of a new drug called SGN-B6A in 6 Chinese patients with advanced solid tumors (lung, head and neck, esophageal, stomach cancers). The main goal was to identify side effects and see how the body processes the drug. It is a first step to see…

This study tested several immunotherapy-based drug combinations in 214 people with advanced stomach, gastroesophageal junction, or esophageal cancer that could not be removed by surgery or had spread. Participants received either standard chemotherapy or chemotherapy plus the imm…

This study tested a new treatment combination (GEN-001 plus avelumab) in 42 people with advanced stomach or gastroesophageal junction cancer that had not responded to at least two prior therapies. All participants had a specific marker (PD-L1 positive) on their tumors. The goal w…

This study tested a new drug (TJ004309) combined with an approved immunotherapy (atezolizumab) in 25 people with advanced ovarian, head and neck, lung, gastrointestinal, or triple-negative breast cancers. The goal was to see if the combination could shrink tumors. Participants ha…

This phase 2 trial tested a combination of two drugs—telatinib (a pill that blocks tumor blood vessels) and Keytruda (an immunotherapy that helps the immune system attack cancer)—in 16 people with advanced stomach, gastroesophageal junction, or liver cancer. The goal was to see i…

This large Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard trastuzumab plus chemotherapy could improve outcomes for people with advanced HER2-positive stomach or gastroesophageal junction cancer. The study enrolled 738 participants …

This study tested whether adding radiation to chemotherapy before surgery improves outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 204 adults with operable tumors received either chemotherapy alone or chemotherapy plus radiation before…

This study tested whether adding fruquintinib to standard chemotherapy (paclitaxel) helps people with advanced stomach cancer live longer. It included 703 patients whose cancer had worsened after initial treatment. The goal was to see if the combination improves survival and slow…

This study tested a combination of the immunotherapy drug tislelizumab and chemotherapy (XELOX) given before surgery to 28 people with locally advanced stomach or gastroesophageal junction cancer. The goal was to see if this approach could shrink tumors more effectively and be sa…

This phase 3 trial tested whether adding an immunotherapy drug called AK104 to standard chemotherapy helps people with advanced stomach or gastroesophageal junction cancer live longer. About 610 participants received either AK104 plus chemo or a placebo plus chemo. The study is c…

This early-phase trial tested a combination of three drugs—afuresertib, sintilimab, and chemotherapy—in 22 adults with solid tumors (including lung, cervical, and stomach cancers) that had stopped responding to prior immunotherapy. The goal was to find a safe dose and see if the …

This study tested whether adding a gut-brain neuromodulator (Flupentixol-Melitracen) to standard acid-reducing therapy (Lansoprazole) helps people with gastroesophageal reflux disease (GERD) who still have symptoms on acid suppressants alone. The trial enrolled 164 adults with GE…

This phase 2 trial tested a combination of two chemotherapy drugs (capecitabine and oxaliplatin) plus two targeted antibodies (bevacizumab and trastuzumab) in 37 people with HER2-positive stomach or esophageal cancer that had spread. The goal was to see how safe and effective the…

This study tested dupilumab, a drug that calms certain immune reactions, in 41 people aged 12-70 with eosinophilic gastritis, a condition where too many immune cells build up in the stomach lining. Participants received either dupilumab or a placebo injection every two weeks for …

This study tested a combination of two drugs, crizotinib and fulvestrant, in 33 people with advanced lobular breast cancer that had lost a protein called E-cadherin. It also tested crizotinib alone in people with diffuse gastric cancer, triple-negative lobular breast cancer, or o…

This study tested a combination of an oral bacterial product (VE800) and the immunotherapy drug nivolumab in 56 people with advanced or metastatic cancers like melanoma, stomach, and colorectal cancer. The goal was to see if the bacteria could help the immune system fight tumors …

This early-stage trial tested a new drug called vibostolimab, either alone or combined with other cancer drugs, in 474 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the dr…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study compared two endoscopic treatments for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal was to see which procedure—radiofrequency ablation or hybrid argon plasma coagulation—causes less pain and is safer from the patient's viewpoint. Sixty-…

This study tested a new device called the Tiara valve, which is implanted through a small tube in the chest to replace the leaky mitral valve without open-heart surgery. It enrolled 157 people with severe mitral regurgitation who were considered too high-risk for traditional surg…

This early study tested a device called the Edwards PASCAL system, which is threaded through a blood vessel to repair the tricuspid valve in the heart. The valve can leak, causing symptoms like shortness of breath and swelling. The study included 65 people with severe leakage who…

This study tested a new drug called SAR444245 combined with other cancer treatments in 138 adults with advanced gastrointestinal cancers, including esophageal, stomach, liver, and colorectal cancer. The goal was to see if the combination could shrink tumors. The study is complete…

This study checked the safety of taking BLI5100 daily for up to 12 months in 400 adults with gastroesophageal reflux disease (GERD). Participants had either non-erosive reflux disease or healed erosive esophagitis. The main goal was to track any side effects. This is a disease co…

This study tested a new treatment for stomach cancer that has spread to the lining of the abdomen. The approach combines standard chemotherapy with a procedure called PIPAC, which delivers chemotherapy as a pressurized aerosol directly into the abdomen during a keyhole surgery. T…

This phase 2 study tested a new drug, FLX475, combined with the immunotherapy pembrolizumab (Keytruda) in 20 people with advanced or metastatic stomach cancer. The goal was to see if the combination could shrink tumors in patients who had already tried other treatments. The study…

This Phase 3 trial tested whether adding the immunotherapy drug camrelizumab to standard chemotherapy, followed by camrelizumab plus the targeted drug apatinib, helps people with advanced stomach or gastroesophageal junction cancer live longer. The study enrolled 885 participants…

This study tested a new drug called zanidatamab (ZW25) combined with standard chemotherapy in 74 people with advanced HER2-positive cancers of the stomach, bile duct, or colon. The goal was to see if the combination is safe and shrinks tumors. Results will help decide if larger s…

This early-phase study tested an experimental drug called TPST-1495, taken as a pill, either alone or combined with the immunotherapy Keytruda (pembrolizumab). The trial included 89 people with advanced solid tumors like colorectal, lung, head and neck, and endometrial cancers wh…

This study tested an experimental drug called ESG401 in 156 people with advanced solid tumors (including breast, lung, and colorectal cancers) who had no other treatment options. The goal was to check the drug's safety, find the right dose, and see if it could shrink tumors. The …

This study tested whether adjusting the dose of a common acid reflux medicine (lansoprazole) based on a child's genes could improve asthma control. 41 children aged 6-17 with uncontrolled asthma and mild reflux participated. Researchers measured changes in asthma symptoms and ref…

This early-phase trial tested a new drug called PTX-100 in 25 people with advanced cancers like multiple myeloma, lymphoma, and certain solid tumors. The goal was to find safe doses and understand how the drug behaves in the body. Participants received the drug by IV for five day…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study tested a new, faster way to diagnose GERD (heartburn disease) using a special probe during a routine endoscopy. The test takes only one minute and may be more comfortable than current methods. Fifteen adults with known reflux participated, and their results were compar…

This pilot study tested a new radioactive tracer called 89Zr-DFO*-trastuzumab in 6 people with HER2-positive breast or gastric cancer. The tracer is designed to attach to HER2 proteins on cancer cells and show up on PET scans. Participants received one injection and had up to 4 P…

This study tested a special capsule with a magnet inside that doctors can control from outside the body. The capsule takes pictures of the stomach to see how it moves and digests food. Researchers wanted to see if this device could help diagnose conditions like gastroparesis and …

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This completed study looked at whether a special PET scan using 18F-FDG can help doctors more accurately diagnose, stage, and track stomach cancer. Researchers studied 50 patients with confirmed gastric cancer, comparing scan results to other tests. The goal was to see if this im…

This study tested an artificial intelligence model that combines CT scans, digital pathology images, and patient history to improve diagnosis and risk prediction for gastrointestinal stromal tumors (GISTs). Researchers enrolled 300 patients with suspected stomach tumors. The AI a…

This study looked at a new test called OSNA to find free cancer cells in the belly fluid of 108 people with stomach or colon cancer who had no visible spread. The goal was to see if OSNA could detect cancer cells better than the usual lab method. If successful, this could help do…

This study tested a new radioactive tracer called [18F]FAPI-74 for PET scans in people with gastrointestinal cancers, including liver, bile duct, stomach, pancreatic, and colorectal cancers. The goal was to see if the tracer can accurately detect cancer cells by comparing scan re…

This study tested a new type of PET scan (FAPI) in 20 people with stomach or gastro-esophageal junction cancer. The goal was to see if FAPI scans are more accurate than standard scans for determining the cancer stage before and after chemotherapy. By comparing scan results with t…

This study tested a training system for confocal laser endomicroscopy (CLE), a technique that lets doctors see cells in real time during an endoscopy. 147 patients with stomach lesions were examined by both experts and trainees. The goal was to see if the training helped doctors …

This study tested whether a special endoscopy technique called ME-NBI (magnifying endoscopy with narrow band imaging) can better diagnose early stomach cancer than the standard white light biopsy. Researchers looked at 211 patients with suspicious stomach lesions. They compared t…

This study tested whether the drug fexuprazan can prevent or control stomach inflammation (gastritis) in people who need to take systemic steroids for at least 4 weeks. 42 adults with respiratory diseases were randomly assigned to take either fexuprazan or the standard drug lanso…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This trial compares two minimally invasive surgical techniques for removing the lower part of the stomach in people with gastric cancer: laparoscopy-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG). The goal is to see which approach leads to b…

This study tests whether a chair-based yoga program is practical and acceptable for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will attend two one-hour yoga sessions and practice at home. Researchers will…

This study tests whether giving IV lidocaine during paraesophageal hernia surgery can reduce pain and speed recovery. About 50 adults having elective laparoscopic hernia repair will receive either lidocaine or a placebo alongside standard pain management. Researchers will measure…

This study tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, bloating, and pain. Twenty-seven adults with idiopathic gastroparesis received CBT sessions and were assessed before an…

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study tested whether PepZinGI, a zinc-L-carnosine supplement, can reduce heartburn triggered by food. Fifty adults with frequent heartburn completed two one-week treatment periods (PepZinGI and placebo) remotely, using wearable devices and surveys to track symptoms and sleep…

This study tested whether Phycocare, a supplement made from spirulina, can reduce nerve damage caused by the chemotherapy drug oxaliplatin in people with metastatic gastrointestinal cancers. 73 participants took either Phycocare or a placebo daily for 9 months. The goal was to se…

This study compared two methods of pain control after open stomach surgery: a nerve block (rectus sheath block) using bupivacaine versus standard epidural pain relief. Sixty adults scheduled for elective open gastrectomy were randomly assigned to one of the two groups. The resear…

This study looked at whether a swaddle blanket with a gentle abdominal band can reduce acid reflux, breathing pauses, heart rate drops, and low oxygen levels in premature infants. About 50 babies in the NICU were observed to see if the blanket helped. The goal was to find a simpl…

This study tested a new disposable bite block for people having routine upper endoscopy. The goal was to see if it reduces complications like dental injury and improves how well the procedure goes. 45 adults took part, and researchers measured how often procedures were completed …

This study looked at whether a special physical therapy program for the core muscles could help people recover after surgery for a ventral hernia. 138 adults who were scheduled for hernia repair took part. The main goal was to see if the therapy improved their mobility and physic…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study tested whether a low-FODMAP diet could help people with gastro-esophageal reflux disease (GERD) whose symptoms persist despite taking standard acid-reducing drugs (PPIs). Thirty-one adults with confirmed reflux were randomly assigned to either a low-FODMAP diet or a st…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether six weeks of supervised Pilates exercises could reduce symptoms of gastroesophageal reflux disease (GERD) in 33 adults. Participants did 18 sessions of posture-focused Pilates or continued their usual daily activities. Researchers measured changes in ref…

This study tested whether Polaprezinc (Zinc-L carnosine) can reduce reflux symptoms in infants aged 1-12 months. Sixty babies were given either the supplement or a thickened formula twice daily for 8 weeks. Researchers measured changes in a reflux symptom questionnaire to see if …

This study tested a new syrup, called Fibroin Syrup, to see if it is safe and can help reduce symptoms of gastroesophageal reflux disease (GERD), like heartburn and regurgitation. The study included 47 adults with non-erosive reflux disease (NERD) who had symptoms for at least 8 …

This study tested whether a special anesthesia plan using dexmedetomidine and ketamine could reduce the need for opioid painkillers after laparoscopic hiatal hernia repair. Fifty adults having elective surgery were randomly assigned to receive either the opioid-sparing protocol o…

This study compared two medications, esomeprazole and vonoprazan, for treating gastroesophageal reflux disease (GERD). Researchers enrolled 824 adults aged 18 to 65 with GERD and measured how many achieved sufficient symptom relief. The goal was to find which drug works better fo…

This study looked at 60 people with a common stomach condition called functional dyspepsia, which causes pain and fullness after meals. Participants were split into two groups: one followed standard advice (small meals, avoid fatty/spicy foods), and the other tried a low FODMAP d…

This study looked at whether placing tiny needles under the skin (intradermal needle therapy) can reduce pain after a stomach procedure called endoscopic submucosal dissection (ESD). 76 patients were randomly assigned to receive either standard care or standard care plus the need…

This study tested whether alginate (Gaviscon) or sucralfate (Ulsanic) provides better symptom relief for people with GERD who are already taking acid-reducing medication (PPIs). 140 adults with frequent severe heartburn took one of the two syrups before meals. Researchers measure…

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study tested if taking itopride once daily works as well as taking it three times a day for people with ongoing stomach discomfort (functional dyspepsia). Over 500 adults participated, and researchers measured symptom changes over 8 weeks. The goal was to see if a simpler do…

This study tested whether a device that sends small electrical pulses to the stomach can help children with severe, long-lasting nausea and vomiting. Thirty kids who hadn't gotten better with standard treatments took part. Each child had a temporary pacing lead placed through a t…

This phase II trial tested a concentrated plant dietary supplement (made from foods like taro, rice, and carrots) in 30 people with gastrointestinal cancers who had diarrhea from chemotherapy. Participants received the supplement alongside standard anti-diarrheal treatment. The g…

This study tested a new way to remove early-stage stomach cancer using a special knife that sprays water to help cut and seal tissue at the same time. The goal was to see if this method (called SPEED) is faster and safer than the usual procedure. The study involved 548 adults wit…

This study looked at 112 adults with stomach blockage caused by advanced cancer. It compared two less invasive procedures: one using an ultrasound-guided bypass and the other using a stent to open the blockage. The goal was to see which method better prevents the blockage from co…

This study looked at whether progressive relaxation exercises can help people with lumbar disc herniation (a slipped disc in the lower back) feel less afraid of moving, have less pain, and enjoy a better quality of life. About 96 adults with confirmed slipped discs were randomly …

This study tested a drug called DLBS2411 in 106 adults with functional dyspepsia, a condition causing stomach pain and fullness without a clear cause. Participants took either the drug or a placebo twice daily for 4 weeks. The goal was to see if the drug improves quality of life …

This small study tested whether taking glutamine powder three times a day can reduce stomach symptoms and improve gut barrier health in people with functional dyspepsia (chronic indigestion without a clear cause). Twelve participants were randomly assigned to receive either gluta…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This early-stage trial tested a new drug called DW4421 in 24 healthy adults to see how food changes the way the body absorbs it. The goal is to learn whether the drug should be taken with or without food for future studies. This is a safety and dosing study, not a test of whether…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested whether taking artemisia and green tea extracts for 8 weeks can improve stomach health in adults with functional dyspepsia (indigestion without a clear cause). 100 participants were randomly assigned to receive the extracts or a placebo. The main goal was to see…

This study tested whether fexuprazan, a new drug, can relieve heartburn and acid reflux as well as the commonly used esomeprazole. 145 adults with GERD took either fexuprazan or esomeprazole once daily for 4 weeks, with an option to continue for another 4 weeks if symptoms didn't…

This study looked at whether having a palliative care team work alongside surgeons improves quality of life for patients with gastrointestinal cancers like pancreatic or liver cancer. About 379 patients and their family members took part. The main goal was to see if this team app…

This study looks at whether a 4-week pre-surgery program of exercise, nutrition advice, and mental support, combined with a standard enhanced recovery plan, can reduce complications after stomach cancer surgery. About 136 patients aged 18-75 who had chemotherapy before surgery wi…

This study tested an experimental drug called CIN-102 (deudomperidone) to see if it can reduce nausea, vomiting, and other stomach symptoms in adults with diabetic gastroparesis—a condition where the stomach empties too slowly. About 382 participants took either the drug or a pla…

This study tested a new procedure that uses an endoscope to create a bypass around a stomach blockage caused by advanced cancer. The goal was to help people eat and drink without major surgery. Fifty-one participants with inoperable cancer and severe blockage were enrolled. The p…

This study tested a non-instrumental biofeedback technique to help people with irritable bowel syndrome or dyspepsia who experience visible abdominal bloating after meals. 41 participants were taught to control their abdominal and chest muscles using a video guide, then practiced…

This study tested whether a high-flow nasal cannula (HFNC) can reduce the risk of low oxygen levels during sedated gastrointestinal endoscopy in 80 adults with high-risk obstructive sleep apnea. Participants had a STOP-Bang score of 5 or higher and were undergoing gastroscopy, co…

This study tested a new way to remove early-stage stomach cancer using a special knife that sprays water while cutting. The goal was to make the procedure faster and safer than the standard method. Researchers looked at 548 patients to compare the new water-injecting technique wi…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This study tested whether gut-directed hypnotherapy (GDH) delivered via telehealth could help manage gastrointestinal symptoms in adults with disorders of gut-brain interaction. Eleven participants completed sessions of general relaxation hypnosis and GDH, plus a 3-month follow-u…

This study looked at whether taking zinc supplements can improve quality of life for people with advanced gastrointestinal cancers (like stomach, liver, or pancreatic cancer) who are receiving chemotherapy. Seventeen patients participated, and researchers measured their quality o…

This completed Phase 3 trial tested whether ENO Lime, a fruit salt powder, can quickly ease symptoms of indigestion, acidity, and nausea. Forty adults with recent symptoms took a single dose, and their discomfort was measured before and 15 minutes after. The study aimed to see if…

This study looked at whether applying a topical diclofenac gel to the hands and feet could prevent or delay hand-foot syndrome in patients with colorectal or gastric cancer taking capecitabine. About 150 patients were observed at two cancer centers in Turkey. The goal was to see …

This study tested whether a liquid dietary supplement called Anvitra Gastric Suspension can reduce heartburn, regurgitation, and indigestion in people with GERD. Twenty-seven adults took the supplement three times daily for 14 days. Researchers measured symptom changes using a st…

This study tested whether aromatherapy (breathing lavender oil) or acupressure (gentle thumb pressure on specific points) could reduce pain and improve sleep in 100 children aged 6-12 after abdominal surgeries like appendix or hernia repair. The goal was to find simple, non-drug …

This completed study looked at whether FEXUCLUE (fexuprazan) tablets can improve heartburn and acid reflux symptoms in people with erosive gastroesophageal reflux disease (GERD). Over 2,800 adults took the medication for 4 to 8 weeks and reported their symptom changes. The goal w…

This study tested a wearable device that delivers mild electrical pulses through the skin, similar to acupuncture, to help relieve stomach symptoms in people with diabetic gastroparesis. 41 participants used the device at either a treatment point or a sham point for 84 days. Rese…

This trial tests whether presenting a cancer screening appointment as a pre-selected default option (opt-out) makes people at high risk for lung or stomach cancer more likely to accept it, compared to a standard opt-in approach. Participants complete an online questionnaire and d…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This study checks if Fitbit devices can accurately measure heart rate, breathing, oxygen levels, sleep, and activity in patients admitted to a general medicine ward. About 100 adults will wear a Fitbit alongside standard monitors to see how well the wearable matches medical-grade…

This study looked at how well a combination of nivolumab (an immunotherapy drug) and chemotherapy works for people with advanced or recurrent stomach cancer who haven't had treatment before. It involved 500 patients in Japan and tracked things like how long the cancer stayed unde…

This early-phase trial tested the safety and tolerability of a drug called X842 in 39 healthy adults. Participants received either single or multiple doses of X842 to see how the body handles it and what side effects may occur. The study is complete and does not aim to treat any …

This study looked at 100 patients who had sleeve gastrectomy for severe obesity. Researchers checked how many developed Barrett's esophagus, a condition that can lead to esophageal cancer, five or more years after surgery. They also examined whether routine endoscopy (a camera te…

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) before surgery helps prevent breathing complications in infants with hypertrophic pyloric stenosis. The condition causes a blockage in the stomach outlet, leading to forceful vomiting.…

This study reviewed medical records of 500 adults treated for benign or malignant pancreatic and stomach diseases from 2005 onward. Researchers looked at overall survival after various treatments. The goal was to understand real-world outcomes, not to test a new drug or procedure…

This study followed 300 adults with functional dyspepsia (chronic stomach discomfort) who were taking standard medications like acid reducers or antidepressants. The goal was to see which factors—such as anxiety or sleep problems—might predict whether symptoms improve after 6 mon…

This study looked at 60 people having stomach cancer surgery to see if adding an epidural to general anesthesia changes how much muscle relaxant is needed and how fast it wears off. Half got general anesthesia alone, half got general anesthesia plus a thoracic epidural. Researche…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This completed study looked at how meals with different amounts and types of fat and carbohydrates affect digestion and blood sugar/fat levels in 12 healthy adults. Participants ate test meals and had blood samples taken over 5 hours. The goal was to understand how meal compositi…

This study created a new tool called the SAH Index to fairly evaluate how well hospitals and surgeons perform gastric cancer surgery. Gastric cancer is serious and often requires major surgery, but comparing results is tricky because patients have different health risks. The rese…

This study followed 280 adults who came to the hospital with a painful hernia needing urgent care. Researchers wanted to see how doctors decide between surgery and non-surgical management, and how patients fared afterward. The goal is to gather real-world data to improve future t…

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study tested whether adding omentopexy — stitching the omentum to the stomach — during sleeve gastrectomy changes stomach shape and emptying. Thirty-six adults having weight-loss surgery were randomly assigned to get the extra stitch or not. Researchers measured stomach angl…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study tracked 295 adults who had high-risk surgery for stomach, esophagus, pancreas, or liver cancer. Researchers measured quality of life before surgery and again at 6 and 12 months after. They also asked patients and their family members if they regretted the decision to h…

This study tested whether using a mask to help patients breathe during anesthesia affects the surgeon's view and bowel condition in robotic colorectal surgery. Sixty adults were randomly assigned to receive mask ventilation or no mask ventilation before intubation. The researcher…

This study tested whether pressing on the esophagus with ultrasound guidance during face-mask ventilation can prevent stomach bloating. 103 adults having laparoscopic surgery were split into two groups: one with the pressure technique and one without. The goal was to see if the t…

This study looked at why many critically ill children develop gut problems like slow digestion and leaky gut. Researchers measured certain proteins linked to inflammation in 99 children to see if they cause these issues. The goal was to better understand the problem, not to test …

This study looked at 13 people undergoing a standard esophagus pressure test to see which breathing positions or maneuvers create the highest pressure at the junction between the esophagus and stomach. The goal is to learn how to better contract the diaphragm, which may help with…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This study looked at whether routinely measuring leftover stomach volume in patients on breathing machines and feeding tubes helps prevent pneumonia. Researchers compared patients who had these checks every six hours to those who did not. The goal was to see if skipping the check…

This early study looked at how two approved constipation drugs, plecanatide and linaclotide, affect a chemical called cGMP in the small intestine. Researchers compared tissue samples from 43 adults with Barrett esophagus or GERD who took either drug or no drug. The goal was to me…

This study looked at 18 women who had sleeve gastrectomy surgery 2-3 years earlier. Researchers compared stomach emptying rates between those who lost a lot of weight (over 35% of total weight) and those who lost little (under 25%). They used MRI and a special scan to measure how…

This pilot study looked at whether repeated FDG-PET/CT scans can help select patients and evaluate how well a special chemotherapy (PIPAC) works for cancer that has spread to the lining of the abdomen. 34 patients with various abdominal cancers were included. The goal was to see …

This completed study from the University of Virginia looked at whether having a hiatal hernia (a stomach issue) is linked to early, undetected lung scarring. Researchers collected blood and lung fluid samples from 14 adults before surgery to measure signs of lung injury. The goal…

This study looked at how many people in Xiamen have gastroesophageal reflux disease (GERD) and what factors might increase their risk. Researchers surveyed 1625 adults who had typical reflux symptoms like heartburn. The goal was to better understand the disease's impact and help …

This completed study looked at 100,000 patient records to find out if people with eosinophilic esophagitis (EoE) are more likely to develop esophageal cancer. The researchers wanted to see if any increased risk is due to EoE itself or to other conditions like acid reflux or Barre…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This study looked at whether routine blood tests taken before surgery can help predict complications and long-term survival in people with gastric cancer. Researchers analyzed data from 3,400 patients across multiple hospitals. The goal was to create a simple tool that helps doct…

This early-stage study looked at how a new GERD drug, linaprazan glurate, changes the way the body processes the antibiotic amoxicillin. Twelve healthy adults took amoxicillin alone and then again after a week of the GERD drug. The goal was to measure drug levels in the blood, no…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study looked at whether injecting botulinum toxin (Botox) into the side belly muscles before large hernia repair surgery can improve breathing. Large hernias can push organs out of place, making surgery tricky and affecting lung function. The study measured lung capacity in …

This completed study looked at 51 adults with stomach cancer in Portugal to see how many carry inherited gene changes linked to the disease. Researchers used a multigene panel test to check for these mutations. The goal was to understand how common these genetic factors are in th…

This completed study examined the mouth bacteria of 30 people, some with gastritis (stomach inflammation) and some without, to see if gum disease and stomach issues are connected. Researchers collected saliva samples and used advanced DNA technology to compare the types and amoun…

This completed study examined how to best manage early-stage upper gastrointestinal cancer in patients who also have liver cirrhosis and enlarged veins in the esophagus (varices). Researchers compared outcomes of a keyhole-like endoscopic surgery (ESD) between 206 patients with a…

This study looked at 186 adults taking GLP-1 RA drugs (like Ozempic) who were scheduled for surgery. Researchers used ultrasound to measure stomach contents at different times after the last dose. The goal was to find out how long it takes for stomach emptying to return to normal…

This study looked at why many cancer patients lose muscle and weight, a condition called cachexia. Researchers collected samples of muscle, fat, blood, and urine from 282 people during cancer surgery and compared them with samples from non-cancer patients. They also measured phys…

This study looked at whether GLP-1 medications (used for diabetes and weight loss) increase the risk of having food or liquid in the stomach before surgery, even after the recommended fasting period. Researchers used a quick ultrasound to check stomach contents in 94 adults sched…

This study tested two types of glottis mask airways (a tube placed in the throat to help patients breathe during anesthesia) to see which one reduces the risk of stomach acid backing up into the throat. The tulip-shaped tip is designed to fit the larynx better than the classical …

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either intravenous propofol or inhaled sevoflurane. Researchers measured pain right after surgery and over …

This study looked at 43 patients who had stomach tumors removed through a scope (no large cuts). Doctors used special clips to stitch the wound closed. The goal was to see if the clips could fully close the hole and how long the procedure took. Results help improve this minimally…

This study looked at 258 adults with untreated oeso-gastric cancer to understand how factors like income, education, and personal beliefs affect the time between first noticing symptoms and seeing a doctor. Researchers measured the median delay from symptom onset to first consult…

This study looked at whether two easy-to-use frailty checklists (FRAIL and FiND) can predict severe side effects from chemotherapy in adults aged 65 and older with gastrointestinal cancers. Researchers followed 84 patients who had already had surgery and were receiving standard c…

This study compared a generic vonoprazan 20 mg tablet to the brand-name Voquezna in 28 healthy adults. Participants took a single dose of each under fasting conditions to see if the generic releases the same amount of drug into the bloodstream. The goal was to check bioequivalenc…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study analyzed blood and tumor tissue samples from 28 people with stomach cancer to find biological markers that predict how well immunotherapy (tislelizumab) combined with chemotherapy works before surgery. The goal was to build a model that uses RNA and other factors to fo…

This study looked back at medical records of 260 adults in China with advanced stomach or gastroesophageal junction cancer who received nivolumab as their first treatment. The goal was to see how well the drug worked in everyday practice and what treatment patterns were used. No …

This study looked at nearly 500 people with stomach and bowel problems to see if a low-FODMAP diet helps reduce symptoms. Researchers also checked for joint hypermobility (very flexible joints) and how the gut microbiome might be linked. The goal is to better understand who benef…

This completed study from Fudan University used a deep learning model to predict whether stomach cancer will come back after surgery. Researchers analyzed data from 5,000 patients across multiple hospitals in Eastern Asia. The model showed strong ability to identify early recurre…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study tested a risk scoring model to predict whether stomach cancer might spread to the liver after surgery. Researchers followed 120 patients who had their stomach cancer removed to see if the model could accurately identify those at higher risk. The goal is to help doctors…

This study looked at whether giving a carbohydrate drink 2 hours before surgery is safe for people with well-controlled type 2 diabetes. 76 adults were split into two groups: one got the drink, the other fasted as usual. Researchers measured blood sugar and checked stomach conten…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked back at 96 patients with advanced stomach cancer who had either partial or total stomach removal. Researchers compared survival rates and recovery to see which surgery might be better. The goal is to help doctors and patients choose the best surgical approach.

This completed study surveyed over 700 primary care doctors, gastroenterologists, and patients across seven U.S. health systems. The goal was to find out what knowledge gaps, attitudes, and practical barriers prevent people from getting screened for Barrett's esophagus, a conditi…

This study tested over 1,000 people in Bhutan for H. pylori, a stomach infection that can lead to stomach cancer. Researchers measured infection rates and stomach damage to understand the problem and plan a national prevention program. Participants were from rural villages, and t…

This study looked at over 8,500 people with stomach cancer in Brandenburg, Germany, from 2000 to 2020. Researchers wanted to understand how the disease and survival differ between men and women. They used cancer registry data to analyze these differences, without giving any new t…

This early-stage study tested two different tablet versions of a drug for gastric ulcers in 46 healthy adults. Participants received a single dose of each formulation on separate occasions to compare how the drug moves through the body and to check for side effects. The goal is t…

This completed study looked at 179 patients with advanced stomach cancer who had chemotherapy and surgery. Researchers used CT scans and genetic data from tumors to build a model that predicts how long patients might stay cancer-free. The goal was to improve survival predictions,…

This completed Phase 1 study tested whether vitamin C (ascorbic acid) tablets can temporarily reduce stomach pH (increase acidity) in 11 healthy young men whose stomach acid was lowered by the drug omeprazole. Participants took vitamin C once and had their stomach pH monitored fo…

This study compared two common positions for a digital rectal exam: lying on your side (lateral decubitus) versus lying on your back (supine). The goal was to see which position allows doctors to perform a more complete exam. The study involved 320 men with conditions like colon …

This study tested whether dexmedetomidine, a sedative often used during surgery, changes how quickly the stomach empties in people having their gallbladder removed. Researchers used ultrasound to measure stomach volume in 80 patients before and after surgery. The goal was to see …

This study tested how two types of soluble fiber—fructooligosaccharide and partially hydrolyzed guar gum—affect how fast food leaves the stomach and moves through the intestines. Twenty-five healthy adults each tried both fibers and a placebo on separate days. The goal was to see…

This study tested a risk scoring model that predicts whether stomach cancer has spread to nearby lymph nodes before surgery. Researchers looked at data from 120 patients who had their stomach cancer removed. The goal was to see if the model could help doctors make better treatmen…

This study used bedside ultrasound to see if people taking semaglutide (Ozempic, Wegovy) have more food or liquid in their stomachs before surgery, despite fasting. Researchers compared 88 adults on semaglutide to those not taking it. The goal was to help anesthesiologists decide…

This study looked at whether waiting 10-12 weeks instead of the usual 4-6 weeks after chemoradiation before surgery helps patients with esophageal or gastric cardia cancer. 202 participants were randomly assigned to one of the two timing groups. The goal was to see if a longer de…