Aerosol chemo shows promise for Hard-to-Treat stomach cancer

NCT ID NCT05644249

Completed Disease control Sponsor: Vilnius University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new treatment for stomach cancer that has spread to the lining of the abdomen. The approach combines standard chemotherapy with a procedure called PIPAC, which delivers chemotherapy as a pressurized aerosol directly into the abdomen during a keyhole surgery. The study included 37 patients and aimed to see if this combination is feasible and safe as a first-line treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin, plus systemic FOLFOX chemotherapy
What this could lead to: If this approach proves effective, it could offer a new first-line treatment option for gastric cancer that has spread to the lining of the abdomen, potentially improving outcomes.
What could go wrong: This was a small, early feasibility study with only 37 participants and no comparison group. The results may not apply to all patients, and the combination treatment carries risks from both chemotherapy and the PIPAC procedure.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm peritoneal carcinomatosis peritoneal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER PERITONEAL CARCINOMATOSIS

Contacts and locations

Locations

Nationa Cancer Institute

Vilnius, Vilniaus, 08406, Lithuania
Vilnius University hospital Santaros Klinikos

Vilnius, Vilniaus, 08661, Lithuania

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