Triple threat before surgery: could a new combo wipe out stomach cancer cells?
NCT ID NCT05941481
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether giving a three-part treatment before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. The treatment combines an immunotherapy drug (tislelizumab) with standard chemotherapy and a short course of radiation. The goal is to see if this approach can completely eliminate the tumor before surgery, potentially leading to better long-term results. The trial enrolls adults with specific stages of the disease who are healthy enough for surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tislelizumab (PD-1 antibody) combined with chemotherapy (capecitabine and oxaliplatin) and hypofractionated radiotherapy
- What this could lead to
- If successful, this approach could increase the chance of complete tumor removal during surgery and improve long-term survival for patients with locally advanced gastric cancer.
- What could go wrong
- This is a small Phase 2 trial, so results may not apply broadly. Combining treatments raises risks of side effects like immune reactions, fatigue, or digestive issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Jiangsu Cancer Hospital
Nanjing, Jiangsu, 210009, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a modified stomach bypass speed up recovery in advanced gastric cancer?