Vitamin c shown to briefly change stomach acidity in small study
NCT ID NCT04199624
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 1 study tested whether vitamin C (ascorbic acid) tablets can temporarily reduce stomach pH (increase acidity) in 11 healthy young men whose stomach acid was lowered by the drug omeprazole. Participants took vitamin C once and had their stomach pH monitored for five hours. The study also looked at how stomach pH changes might relate to gut bacteria and metabolites.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vitamin C (ascorbic acid)
- What this could lead to
- If successful, this could point toward a simple way to temporarily adjust stomach acidity for certain medical situations.
- What could go wrong
- This is a very small, early-phase study in healthy young men only, so results may not apply to patients or real-world conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States