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Which mesh placement is safer for hernia repair? new trial investigates

NCT ID NCT07401446

Disease control Sponsor: Hayat Abad Medical Complex, Peshawar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed trial compared two surgical techniques for repairing incisional hernias: placing mesh on top of the abdominal muscle (onlay) versus behind it (sublay). 350 adults were randomly assigned to one of the two procedures and followed for three months. The goal was to see which method leads to fewer complications like infection, fluid buildup, or hernia recurrence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
polypropylene mesh
What this could lead to
If one method proves safer, it could become the preferred surgical approach for incisional hernia repair, reducing complications like infection and recurrence.
What could go wrong
This is a single-center trial with short follow-up (3 months), so results may not apply to all patients or predict long-term outcomes. Individual surgeon skill may also affect results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

350 people

The number who actually took part.

Started

Aug 2020

Finished

Sep 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-60 years. * Patients diagnosed with primary incisional hernia on clinical examination. * Hernia suitable for open surgical repair with mesh. * Both male and female patients. * Patients able and willing to provide written informed consent. Exclusion Criteria: * Obstructed or strangulated hernia on presentation. * Recurrent incisional hernia. * Patients with BMI \> 40. * Patients with debilitating chronic diseases, including: * Chronic liver disease * Chronic renal impairment * Chronic cardiac disease * Chronic pulmonary disease * Patients with American Society of Anesthesiologists (ASA) physical status ≥ 3. * Patients unfit for general anesthesia. * Patients unable or unwilling to follow up for postoperative assessment.

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Conditions

The condition(s) this trial relates to.

Hernia Hernia, Abdominal hiatus hernia Incisional Hernia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal wall hernia Hernia Incisional hernia repair Synthetic mesh Ventral hernia repair

Contacts and locations

Locations

  • Hayatabad Medical Complex

    Peshawar, KPK, 25000, Pakistan

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