New combo attack on stomach cancer shows promise in small trial

NCT ID NCT05379972

Completed Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested a combination of radiation, a targeted drug (olaparib), and an immunotherapy (pembrolizumab) in 9 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if this approach could shrink tumors that were not directly irradiated. The study is complete, but results are not yet widely available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pembrolizumab (Keytruda), Olaparib (Lynparza), and Stereotactic Body Radiation Therapy (SBRT)
What this could lead to: If successful, this combination could point toward a new treatment option for advanced gastric and GEJ cancers that have not responded to prior therapy.
What could go wrong: This is a very small, early-phase trial with only 9 participants. Results may not apply to all patients, and the combination may cause significant side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER GASTROESOPHAGEAL CANCER

Contacts and locations

Locations

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States
UCHealth Memorial Hospital Central

Colorado Spring, Colorado, 80909, United States
UCHealth Memorial Hospital North

Colorado Springs, Colorado, 80909, United States
University of Colorado Health

Aurora, Colorado, 80045, United States

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