New combo attack on stomach cancer shows promise in small trial
NCT ID NCT05379972
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tested a combination of radiation, a targeted drug (olaparib), and an immunotherapy (pembrolizumab) in 9 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if this approach could shrink tumors that were not directly irradiated. The study is complete, but results are not yet widely available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pembrolizumab (Keytruda), Olaparib (Lynparza), and Stereotactic Body Radiation Therapy (SBRT)
What this could lead to
If successful, this combination could point toward a new treatment option for advanced gastric and GEJ cancers that have not responded to prior therapy.
What could go wrong
This is a very small, early-phase trial with only 9 participants. Results may not apply to all patients, and the combination may cause significant side effects without improving outcomes.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for GASTRIC CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, 80129, United States
-
UCHealth Memorial Hospital Central
Colorado Spring, Colorado, 80909, United States
-
UCHealth Memorial Hospital North
Colorado Springs, Colorado, 80909, United States
-
University of Colorado Health
Aurora, Colorado, 80045, United States