New drug shows promise in early trial for kids with deadly brain cancer
NCT ID NCT04295759
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking a protein that helps tumors grow. While not a cure, this research is a first step toward a new treatment option for a difficult-to-treat childhood cancer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60614, United States
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Children Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90026, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02245, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Stanford University and Lucile Packard Children's Hospital
Palo Alto, California, 94304, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a parasite drug fight childhood brain tumors?
- Can mapping the Blood-Brain barrier in brain tumors unlock new clues?
- Can a pill that starves tumors of oxygen help fight advanced cancer?
- Brain cancer vaccine targets survivin protein to boost immune attack
- Engineered immune cells target deadly brain tumors in children
- AI reads brain scans to predict tumor survival before surgery