Which works better for h. pylori? triple vs quadruple therapy showdown
NCT ID NCT07312721
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omeprazole, metronidazole, tetracycline, bismuth). Six weeks after treatment, a stool test checked if the infection was gone. The goal is to find which regimen works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Omeprazole, amoxicillin, clarithromycin (triple therapy) or omeprazole, metronidazole, tetracycline, bismuth subsalicylate (quadruple therapy)
What this could lead to
If one regimen proves more effective, it could become the preferred standard treatment for H. pylori infection, reducing ulcers and gastritis.
What could go wrong
This is a completed Phase 4 trial, so results are already in. However, the study was done at a single center in Pakistan, so findings may not apply everywhere. Both regimens have side effects like nausea or diarrhea.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shahida Islam Medical College, Lodhran
Lodhran, Punjab Province, 59320, Pakistan