Gastric intestinal metaplasia

This study tests whether the drug pyrvinium can reverse gastric intestinal metaplasia, a condition that raises the risk of stomach cancer. Thirty-two adults with high-risk features will take pyrvinium or a placebo for 14 days. Researchers will compare biopsies before and after tr…

This study tests whether ursodeoxycholic acid, a bile acid medication, can reverse gastric intestinal metaplasia—a condition where the stomach lining changes and raises cancer risk. Researchers will give 196 adults without H. pylori infection either the drug or a placebo for 6 mo…

This study is testing a new blood test called PanTum Detect to see how well it can find early signs of cancer or pre-cancer. The test looks for certain markers in immune cells. Researchers will compare the blood test results with standard PET/CT scans in 134 adults—half with susp…

This study tests an artificial intelligence system designed to automatically score precancerous changes in the stomach lining during endoscopy. Researchers will compare the AI's scores to those of expert doctors in 3,000 participants aged 40-75. The goal is to see if the AI can r…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is investigating whether exposure to microplastics is linked to the development of stomach cancer and its early stages. Researchers will ask 450 people with different stomach conditions to fill out a detailed questionnaire about their possible exposure to microplastics…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…

This study is building a registry of 3,200 people with early changes in the stomach lining that can lead to gastric cancer. Researchers will collect information on lifestyle, diet, and other risk factors through questionnaires. The goal is to better understand why some people dev…

This study follows 600 people at higher risk for stomach cancer to track precancerous changes in the stomach lining. Researchers collect tissue, blood, and saliva samples during routine endoscopies. The goal is to understand why some people's stomach changes progress to cancer wh…

This study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …