Can a common bile acid pill reverse stomach changes that lead to cancer?

NCT ID NCT06610760

Recruiting now Disease control Sponsor: Yongquan Shi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether ursodeoxycholic acid, a bile acid medication, can reverse gastric intestinal metaplasia—a condition where the stomach lining changes and raises cancer risk. Researchers will give 196 adults without H. pylori infection either the drug or a placebo for 6 months, checking every 4 weeks. The goal is to see if the drug can make the abnormal tissue regress or prevent it from worsening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ursodeoxycholic acid
What this could lead to: If it works, this could offer a non-invasive way to reverse a precancerous stomach condition, potentially reducing stomach cancer risk.
What could go wrong: This is a phase 4 trial, but the condition is hard to reverse and previous treatments have had mixed results. The benefit may be small or absent, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric intestinal metaplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC INTESTINAL METAPLASIA

Contacts and locations

Locations

989 Hospital of PLA Joint Logistics Support Force
RECRUITING

Pingdingshan, Henan, China
Ankang Central Hospital
RECRUITING

Ankang, Shaanxi, China
Hanzhong 3201 Hospital
RECRUITING

Hanzhong, Shaanxi, China
Shangluo Central Hospital
RECRUITING

Shangluo, Shaanxi, China
Xi'an Central Hospital
RECRUITING

Xi'an, Shaanxi, China
Xijing hospital
RECRUITING

Xi'an, Shaanxi, 710032, China

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