Can a common supplement reverse stomach cancer risk?
NCT ID NCT07129460
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether berberine, a natural compound, can reverse gastric intestinal metaplasia—a precancerous condition in the stomach lining. Researchers will give 204 adults without H. pylori infection either berberine or a placebo daily for 6 months, checking every 4 weeks to see if the condition improves or worsens. The goal is to find a safe, effective way to lower stomach cancer risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- berberine hydrochloride
- What this could lead to
- If it works, this could point toward a simple, low-cost treatment to reverse precancerous stomach changes and reduce stomach cancer risk.
- What could go wrong
- This is a Phase 4 trial with only 204 participants, so results may not apply to everyone. Berberine may not work better than placebo, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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