Can a common supplement reverse stomach cancer risk?
NCT ID NCT07129460
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether berberine, a natural compound, can reverse gastric intestinal metaplasia—a precancerous condition in the stomach lining. Researchers will give 204 adults without H. pylori infection either berberine or a placebo daily for 6 months, checking every 4 weeks to see if the condition improves or worsens. The goal is to find a safe, effective way to lower stomach cancer risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
berberine hydrochloride
What this could lead to
If it works, this could point toward a simple, low-cost treatment to reverse precancerous stomach changes and reduce stomach cancer risk.
What could go wrong
This is a Phase 4 trial with only 204 participants, so results may not apply to everyone. Berberine may not work better than placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••