New drug combo shows promise for tough stomach cancers

NCT ID NCT04053205

Completed Disease control Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called gentuximab combined with the chemotherapy drug paclitaxel in 76 people with advanced stomach or gastroesophageal junction cancer that had worsened after initial treatment. The goal was to find a safe and effective dose and see if the combination could shrink tumors or slow the cancer's growth. The trial focused on safety and early signs of benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gentuximab (a drug) combined with paclitaxel (a chemotherapy drug)
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced gastric cancer that has stopped responding to initial chemotherapy.
What could go wrong: This is an early-phase trial with only 76 participants, so results may not apply to everyone. The combination may cause significant side effects, and it is not yet known if it improves survival compared to standard treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED GASTRIC OR GASTROESOPHAGEAL JUNCTION CANCER

Contacts and locations

Locations

Fujian Tumor Hospital

Fuzhou, Fujian, China
Jiangsu Province Hospital

Nanjing, Jiangsu, China
Shanghai East Hospital

Shanghai, China
Shanghai First People's Hospital

Shanghai, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The Affiliated Tumor Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China
The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The First Hospital of Jilin University

Changchun, Jilin, China
The Sixth Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

Hangzhou, Zhejiang, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

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