New drug combo shows promise in early cancer trial
NCT ID NCT05867121
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested a new drug called RO7496353 combined with an immunotherapy (atezolizumab) and sometimes chemotherapy in 102 people with advanced lung, stomach, or pancreatic cancer. The main goal was to check safety and side effects. Researchers also looked at how the drug moves through the body and whether it shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RO7496353 (a drug) combined with atezolizumab (an immunotherapy) and/or chemotherapy drugs like capecitabine, S-1, or nivolumab
What this could lead to
If it works, this could point toward a new treatment option for people with advanced solid tumors that are hard to treat.
What could go wrong
This is an early Phase 1 trial, so the main goal is safety, not effectiveness. The combination may not work well or could cause serious side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda
Milan, Lombardy, 20162, Italy
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Ankara City Hospital
Ankara, 06800, Turkey (Türkiye)
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Asan Medical Center
Seoul, 05505, South Korea
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Auckland City Hospital
Auckland, 1023, New Zealand
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Centro Ricerche Cliniche Di Verona
Verona, Veneto, 37134, Italy
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Clinica Universidad de Navarra-Madrid
Madrid, 28027, Spain
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Clinica Universitaria de Navarra
Pamplona, Navarre, 31008, Spain
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Dokuz Eylul Universitesi Tip Fakultesi
Lzmir, 35340, Turkey (Türkiye)
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Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
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Fondazione Policlinico Universitario A Gemelli
Rome, Lazio, 00168, Italy
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Hospital de Câncer de Barretos
Barretos, São Paulo, 14784-400, Brazil
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Kanagawa Cancer Center
Kanagawa, 241-8515, Japan
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NEXT Oncology-Hospital Quironsalud Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
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National Cancer Center Hospital
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East
Chiba, 277-8577, Japan
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Samsung Medical Center - PPDS
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System - Clinical Trials Center Pharmacy
Seoul, 120-752, South Korea
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Shizuoka Cancer Center
Shizuoka, 411-8777, Japan
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St Vincent'S Hospital
Darlinghurst, New South Wales, 2010, Australia
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The Cancer Institute Hospital of Japanese Foundation For Cancer Research
Tokyo, 135-8550, Japan
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591, South Korea
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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UCLA University of California Los Angeles
Los Angeles, California, 90095, United States
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Yale School of Medicine
New Haven, Connecticut, 06510-3206, United States