New drug combo shows promise for rare breast cancer
NCT ID NCT03620643
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a combination of two drugs, crizotinib and fulvestrant, in 33 people with advanced lobular breast cancer that had lost a protein called E-cadherin. It also tested crizotinib alone in people with diffuse gastric cancer, triple-negative lobular breast cancer, or other tumors with a CDH1 gene mutation. The main goal was to see if the treatment could shrink tumors and to check for side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
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Guys and St Thomas NHS Foundation Trust
London, United Kingdom
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Royal Marsden NHS Foundation Trust
London, SW3 6JJ, United Kingdom
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The Christie NHS Foundation Trust
Manchester, United Kingdom
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University College London Hospital
London, United Kingdom