New drug combo shows promise for Hard-to-Treat breast cancer

NCT ID NCT03620643

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times

Summary

This study tested a combination of two drugs, crizotinib and fulvestrant, in 33 people with advanced lobular breast cancer or other cancers linked to a CDH1 gene mutation. The goal was to see if the treatment could shrink tumors and to check for side effects. While both drugs had been studied before, this was the first time they were used together.

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Contacts and locations

Locations

  • Beatson West of Scotland Cancer Centre

    Glasgow, United Kingdom

  • Guys and St Thomas NHS Foundation Trust

    London, United Kingdom

  • Royal Marsden NHS Foundation Trust

    London, SW3 6JJ, United Kingdom

  • The Christie NHS Foundation Trust

    Manchester, United Kingdom

  • University College London Hospital

    London, United Kingdom

Conditions

Explore the condition pages connected to this study.