Neurovascular disorder

This small Phase 2 study tested INV-102 eye drops in 19 people with diabetic macular edema, a swelling in the back of the eye caused by diabetes. Participants used the drops daily for 8 to 12 weeks. The goal was to see if the drops could improve retinal health and reduce swelling…

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

Researchers at Tanta University are testing whether a high-dose version of the eye injection aflibercept (8 mg) can improve vision in people with diabetic macular edema or retinal vein occlusion that has not responded well to earlier anti-VEGF treatments. The study enrolls 60 adu…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

Researchers compare two approaches for proliferative diabetic retinopathy, a condition where abnormal blood vessels grow in the retina and can cause vision loss. One group receives standard pan-retinal laser photocoagulation alone. The other receives the same laser treatment plus…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vis…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This completed Phase 4 trial tested whether adding a second drug (B55R2) to standard treatment (B55R1) works better for people with non-proliferative diabetic retinopathy, an early stage of diabetic eye disease. 52 adults with mild to severe disease took either the combination or…

This trial tests whether a home-based virtual reality rehabilitation program called Muvity can improve arm function, balance, and quality of life in people who had a stroke more than six months ago. Participants will be split into two groups: one doing the Muvity program at home …

This trial tests a virtual reality system called RGS that guides stroke survivors through reaching, grasping, and placing virtual objects to aid motor and cognitive recovery. The study enrolls adults who have had a first stroke with mild to moderate arm weakness. Participants use…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

This study tested a set of simple, affordable robots called Rehab CARES to help older adults who had a stroke improve arm and hand function. Twenty-seven participants used the robots for one-hour sessions, three times a week for four weeks, while also receiving standard therapy. …

This trial compares two types of technology-assisted balance training for people who had a stroke at least six months ago. One group trains balance using ankle movements, the other uses hip movements, and both also receive a standard rehabilitation program. The goal is to see whi…

This trial tests whether delivering electrical stimulation underwater can help people recovering from a stroke regain hand grip strength and arm movement. Participants who had a stroke within the past six months will receive either real underwater faradic stimulation or a sham ve…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This phase 2 trial tests whether taking colchicine, an anti-inflammatory drug, once daily can prevent major cardiovascular events like heart attacks and strokes in people who have just had a brain bleed (intracerebral hemorrhage). The study includes about 100 adults who have had …

This trial tests whether pairing vagus nerve stimulation (VNS) with rehabilitation can improve arm function in people who have had an ischemic stroke. Participants receive an implanted VNS device and undergo weeks of therapy, with some receiving active stimulation and others a sh…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This trial tests whether a rehabilitation technique called error-augmented walking can improve gait and brain activity in people who have had a stroke. Participants walk on a split-belt treadmill, which makes the two belts move at different speeds to create a deliberate mismatch,…

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This trial tests whether a four-week course of electroacupuncture changes tongue appearance in people recovering from an ischemic stroke. Researchers will use an automated tongue imaging system to capture and analyze tongue color, shape, and coating before and after treatment. Th…

This trial tests whether a specific acupuncture technique, called Xingnao Kaiqiao (or 'Brain Awakening'), can improve arm movement in people recovering from a stroke. It compares this method to standard electroacupuncture. The study involves 66 adults aged 40-80 who had a stroke …

This trial tests whether adding respiratory muscle training to a standard post-stroke wellness program improves breathing strength, physical activity, and quality of life more than the wellness program alone. Stroke survivors who are at least six months post-stroke will participa…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This trial tests whether giving the clot-busting drug alteplase directly into the brain artery, right after a mechanical thrombectomy has reopened a blocked vessel, can improve recovery from acute ischemic stroke. The study enrolls adults with large-vessel blockages in the front …

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This trial tests whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain to help people recover arm and hand function after a stroke. Researchers will try different intensities and frequencies of ultrasound in stroke survivors to find the best settings that…

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery, right after a standard procedure to remove a clot, can help people who have had a severe ischemic stroke. The study includes adults aged 18-85 with a blocked artery in the fron…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This study tests whether an implanted device that stimulates the vagus nerve, combined with physical therapy, can improve arm movement in people who have had a stroke. The trial includes adults with chronic upper-limb weakness who have already received the implant and completed r…

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls…

This trial investigates whether adding a dexamethasone implant (Ozurdex) to standard aflibercept (Eylea) injections can better control diabetic macular edema that has not responded to anti-VEGF therapy alone. Adults with persistent retinal swelling will receive either the combina…

This study compares two ways to perform carotid artery stenting—a procedure that opens narrowed neck arteries to prevent stroke. The standard method uses an artery in the groin, while the experimental method uses an artery in the wrist. Researchers will enroll 3000 adults with si…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests a drug called Ir-CPI in 23 people who have had a bleeding stroke (intracerebral hemorrhage). The drug is given once through a vein over 48 hours, alongside standard care. The goal is to see if it is safe and can reduce swelling and further brain damage around the…

This study follows over 500 adults with migraine who have not responded well to other preventive treatments. Participants take atogepant as prescribed by their doctor and are monitored for a year to see how well it reduces headache and migraine days, and how long they stay on the…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) within 6 hours after a stroke procedure (thrombectomy) could prevent early neurological worsening. 60 adults with large-vessel stroke were randomly assigned to receive either the drug plus standard…

This study tested a new device called the Millipede System in 246 stroke patients with large blood clots in the brain. The device is designed to remove clots and restore blood flow. Researchers measured how often blood flow was successfully restored and tracked any side effects. …

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This clinical trial tests whether adding the drug glenzocimab to standard endovascular therapy (a procedure to remove blood clots) improves recovery in people with acute ischemic stroke. The study includes adults aged 18 and older who are eligible for clot removal within 24 hours…

This study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…

This study tests whether a robotic hand device can help people recovering from a stroke improve hand strength and dexterity better than standard physical therapy. Thirty adults with sub-acute stroke (2 weeks to 6 months post-stroke) will be randomly assigned to receive either rob…

This trial tests whether an experimental drug called Y-3, given as an injection for 10 days, helps people recover better after an acute ischemic stroke. The study includes Chinese adults who had a stroke within the past 48 hours and have moderate to severe symptoms. Participants …

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This study tests whether adding a traditional Chinese herbal decoction (Buyang Huanwu Decoction combined with Wuling Powder) to standard stroke care helps people recover better after an acute ischemic stroke. Participants receive either standard care alone or standard care plus t…

This study tests whether a structured nursing program, based on the Plan-Do-Check-Act quality improvement cycle, can reduce lung infections in stroke patients who have a tracheostomy (a breathing tube in the neck). The program includes careful airway care, suctioning, and early r…

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study compares a virtual reality (VR) rehabilitation program that combines movement and cognitive training in realistic everyday environments with conventional occupational therapy for people who have had a stroke. The goal is to see if the VR program leads to greater improv…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This phase 2 trial tests whether baricitinib, an anti-inflammatory drug, can improve neurological outcomes in people who have had a spontaneous intracerebral hemorrhage (a type of stroke caused by bleeding in the brain). About 110 adults in China will receive either baricitinib p…

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study looked at how well eptinezumab works and is tolerated for preventing migraines. It included 130 adults with episodic or chronic migraine. Researchers tracked changes in monthly migraine days over 3 to 12 months of treatment.

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested a new intensive therapy called I-ACQUIRE for infants aged 8 to 36 months who had a stroke around birth and have weakness on one side. The therapy involves guided play and movement exercises for either 3 or 6 hours a day, 5 days a week for 4 weeks. Researchers co…

This study tested a new eye medication called PRO-169 against a standard drug (ranibizumab) for people with diabetic macular edema, a condition that causes vision loss in people with diabetes. About 509 adults with diabetes took part, receiving injections into the eye over one ye…

This pilot study tested a device called Fesia Grasp that uses electrical stimulation to help people recovering from a stroke regain hand function. Sixteen participants with arm weakness after a subacute stroke received either Fesia Grasp therapy or standard physical therapy. The …

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This study tested a new way of caring for stroke patients that brings together doctors, nurses, and family members using technology and teamwork. About 1,200 adults who had a stroke took part. The goal was to see if this coordinated care helps people recover better and have a hig…

This study tested whether using social networks (like family and friends) can help people at high risk for stroke stick to their medications and control risk factors after leaving the hospital. Researchers enrolled 720 patients and compared standard care with a social network-bas…

This study looked at whether a procedure to remove a blood clot from the brain (endovascular therapy) works better than medication alone for people with mild stroke symptoms and a visible clot. About 4,800 adults with mild stroke were included. The goal was to see which approach …

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes i…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This pilot study tested whether low-frequency magnetic stimulation (rTMS) applied to the brain within 48 hours of an acute ischemic stroke could reduce the growth of damaged tissue and lower disability. Sixty adults aged 18–80 with moderate to severe strokes were enrolled. The tr…

This study looked at whether faricimab injections can help people with diabetic retinopathy, a diabetes-related eye disease. Over 12 months, 60 patients received the treatment and doctors measured changes in the back of the eye. The goal was to see if the drug could reduce abnorm…

This study tested whether low-frequency magnetic brain stimulation (rTMS) can improve recovery in 60 people who had a severe stroke and received emergency treatment to reopen blocked arteries. Participants received either real or sham stimulation for 3 days after their procedure.…

This study tested two blood thinners—tirofiban and aspirin—in 240 stroke patients who also had a severe blockage in the neck artery. The goal was to see which drug better prevents the artery from reclosing after emergency surgery, while also checking for bleeding risks. Results w…

This study tested a drug called faricimab in 179 people with non-proliferative diabetic retinopathy, a condition where diabetes damages blood vessels in the eye. The goal was to see if the drug could improve blood flow in the retina over 48 weeks. Participants received either mon…

This study tested whether using a special tongue brush (Orabrush) can lower the chance of aspiration pneumonia and improve swallowing in people who had a stroke. Researchers enrolled 252 stroke patients and compared those who used the brush to those who did not. The goal was to s…

This study tested whether using a balloon-guided catheter helps doctors remove blood clots more effectively in people having a stroke. 110 adults with acute ischemic stroke were randomly assigned to receive clot removal with either a balloon-guided or standard catheter. The main …

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study tested the drug upadacitinib (RINVOQ) in 429 people with giant cell arteritis, a condition causing inflamed blood vessels. Participants took the drug or a placebo along with steroids. The goal was to see if upadacitinib helps achieve remission faster and with less ster…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study tested whether special pelvic floor exercises can help stroke survivors who have weak pelvic muscles and sexual problems. 140 people who had a stroke at least a year ago took part. The goal was to see if these exercises improve muscle strength and sexual function over …

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study looked at the long-term safety of faricimab, a medicine injected into the eye, for people with diabetic macular edema (DME). About 1,500 patients who had completed earlier studies received faricimab at personalized intervals. The main goal was to track side effects, no…

This study tested a simple procedure called remote ischemic conditioning (RIC) in 100 people with narrowed neck arteries who were having surgery to clear the blockage. RIC involves briefly inflating a blood pressure cuff on both arms to temporarily stop blood flow, then releasing…

This study tested a device called the Lariat to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal was to reduce the risk of stroke. Nine participants were enrolled, and the study measured h…

This study looked at 30 adults who had brain surgery after a hemorrhagic stroke and needed blood pressure control in the ICU. Researchers compared two IV medicines, nicardipine and labetalol, to see which one better controlled blood pressure and heart rate during the first 24 hou…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study compares two ways to remove large blood clots from the brain during a stroke: direct aspiration (ADAPT) and using a stent retriever. About 381 adults with stroke caused by a blocked artery in the front part of the brain took part. The goal is to see which method clears…

This study tested whether giving two blood thinners (ticagrelor and aspirin) early, along with standard clot-busting treatment, helps people recover better after a stroke. Over 1,300 patients with mild to moderate stroke were treated within 6 hours of symptoms. The goal was to se…

This study tested whether eating one avocado and one cup of mango daily for 8 weeks could improve blood vessel health and thinking in 82 adults with pre-diabetes. Participants were randomly assigned to either a diet including these fruits or a matched control diet. Researchers me…

This study tested whether using a bronchoscope (a thin tube with a camera) to clean the lungs could help people who develop pneumonia and swallowing problems after a stroke. 50 patients were split into two groups: one received standard care, and the other also got 1-2 bronchoscop…

This study tested a procedure called TCAR to treat blocked carotid arteries (major neck arteries). 55 patients with severe blockages were treated, and researchers used brain scans to check for new small brain lesions after the procedure. The goal was to see how safe the procedure…

This Phase 2 trial tested the safety of an experimental drug called RNS60 in 83 people having a severe stroke caused by a large blood clot. Participants received either RNS60 or a placebo as a 48-hour infusion, starting within 30 minutes of consent. The main goal was to check for…

Researchers are studying how measurements from two different optical coherence tomography (OCT) machines compare when scanning the back of the eye. The trial includes 338 adults with diabetes and diabetic macular oedema. Participants receive OCT scans on both a Heidelberg Spectra…

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a new tool called BESTA, designed to quickly diagnose aphasia (language problems) in people who just had a stroke. Researchers compared BESTA to an existing test in 395 participants, including stroke patients and healthy volunteers. The goal was to see if BESTA …

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested whether a non-invasive device placed on the forehead (NIRS) can detect blood vessel spasms in the brain after a severe aneurysm rupture. Fifty patients were monitored continuously from day 4 to day 12 after their bleed. The goal was to see if this oxygen-measuri…

This study looked at whether a special type of CT scan (dual-energy CT) can more accurately tell the difference between bleeding and harmless contrast dye in the brains of stroke patients after treatment. About 189 adults who had a stroke and received clot-busting drugs or a clot…

This study tested whether chewing gum can help doctors diagnose giant cell arteritis (Horton's disease), a condition where blood vessels become inflamed. The idea is that chewing may trigger jaw pain in people with the disease, making it easier to spot. Researchers compared resul…

This study tested a device called NIRSITX that uses light to measure oxygen levels in the brain. Researchers compared oxygen readings from the injured side of the brain to the healthy side in 35 adults who had a stroke within the past week. The goal was to see if the device could…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study tested a new thinking test called CASP for stroke patients. The test is designed to work even for patients who have trouble speaking after a stroke. Researchers checked how well the test works by comparing it to other tests in 263 patients.

This study looked at whether a PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a type of blood vessel inflammation. Researchers compared the scan results to those from ultrasound and MRI in 70 patients suspected of having the condition. The goal was…

This study tested whether special MRI scans can better detect signs of central retinal artery occlusion (CRAO), also known as an eye stroke. Researchers enrolled 63 adults with CRAO and performed detailed brain and eye imaging. The goal was to find imaging clues that help diagnos…

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

Researchers are testing whether 24 weeks of Tai Chi training can prevent episodic migraines in Chinese women as effectively as standard preventive medication. The trial enrolls 220 women aged 18 to 65 who have two to six migraines a month. Participants in the Tai Chi group attend…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tested a new way to position the weak arm in stroke patients to prevent shoulder pain, a common problem that can slow recovery. 76 people who had a stroke within the last 48 hours took part. The program used special supports and slings, along with training for patients…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This completed clinical trial tested a procedure called ischemic postconditioning to prevent brain damage in 40 people undergoing carotid surgery for severe artery narrowing. The procedure involves briefly clamping and unclamping the carotid artery in cycles after surgery to prot…

This study looked at whether a simple oral hygiene routine could prevent a serious lung infection called aspiration pneumonia in people hospitalized after a stroke. Researchers compared 90 stroke patients who received structured mouth care from nurses to similar patients who got …

This study tested a drug called eptinezumab to see if it can prevent migraines in people with chronic migraine (15 or more headache days per month). About 981 adults took part, receiving either the drug or a placebo. The main goal was to see if the drug reduced the number of mont…

This pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …

Researchers are testing whether stroke patients can safely use a hand rehabilitation robot called ReHandyBot on their own, first in a clinic and then at home. The study enrolls 15 adults who recently had a stroke and have hand weakness. Participants learn to use the robot with a …

This study tests whether applying kinesio tape to the neck muscles can improve swallowing safety in people who have trouble swallowing after a stroke. Researchers will measure changes in swallowing using a special X-ray video before and right after the tape is applied. The study …

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers are testing whether certain ingredients in toothpaste can trigger migraines. Adults with migraine who do not take preventive medicines join one of two groups: one swaps toothpaste for saline solution when brushing, the other keeps using toothpaste. Both groups follow …

Researchers are testing a 12-week home-based programme that combines aerobic exercise, strength training, stretching, and self-management education for people who had a stroke more than six months earlier. The trial enrolls 30 community-dwelling survivors aged 20 to 59 who can wa…

Researchers are testing whether a dual-task exercise program helps stroke survivors walk while doing a mental task. The study compares dual-task training, which combines walking with cognitive activities, to single-task training, where walking and thinking are practiced separatel…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study tests whether dry needling (inserting thin needles into tight muscles) can reduce spasticity—stiffness that makes movement hard—in people who have had a stroke. About 28 adults who can walk independently will receive either real or sham (fake) needling once a week for …

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This trial tests a support package called CaknaStrok for people caring for a family member who just had a stroke. The package includes a mobile app with videos and tools, plus a guidebook, all tailored for Malaysian caregivers. Researchers compare caregivers who get the package w…

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 participants who had a stroke 3 months to 1 year ago will do either isokinetic knee exercises or standard rehab. The goal is …

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

Researchers are testing whether an electromyography-controlled functional electrical stimulator (FitFES) helps stroke survivors regain arm and hand function. The device reads muscle signals and delivers electrical stimulation during task-oriented exercises. Fifty adults who had a…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

Stroke often damages trunk control, balance and walking ability. Researchers are testing whether combining transcranial direct current stimulation, a mild electrical current applied to the scalp, with pelvic proprioceptive neuromuscular facilitation, a hands-on stretching and mov…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests a rehabilitation method called modified constraint-induced movement therapy (mCIMT) for people recovering from a stroke. Participants wear a mitten on their unaffected arm for several hours a day while practicing tasks with the affected arm. The goal is to see if…

This trial tests whether playing different types of music during retinopathy of prematurity (ROP) eye exams can reduce pain and improve comfort in premature infants. ROP exams are necessary but can be painful and stressful for babies. Researchers will compare pain and comfort sco…

This trial tests whether two types of talking therapy can help people with chronic migraine. One is standard cognitive behavioral therapy, and the other is a traditional Islamic psychotherapy that blends psychological methods with Islamic principles. Adults aged 18 to 40 with a n…

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This study looks at whether fremanezumab, a migraine prevention drug, can reduce the emotional burden on caregivers of people with migraine and depressive symptoms. Researchers will measure caregiver stress and the quality of the couple's relationship before and after six months …

This study tests whether wearable sensors and goal-setting sessions with a physiotherapist can help stroke survivors stay active after leaving inpatient rehabilitation. Participants wear sensors to track activity, sleep, and sedentary behavior, and some receive feedback and set g…

This study explores whether interactive music and guided imagery, delivered via telehealth, can help ease migraines. Researchers will check if the approach is practical and acceptable for Veterans, and whether it leads to meaningful changes in headache frequency and related outco…

This study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…

This study tests whether intensive robotic arm training can help people recovering from a stroke improve arm movement and reduce stiffness. Participants will use two types of robotic devices in 12 sessions over four weeks. Researchers will also use a technique called muscle syner…

This trial explores whether exposure to artificial light that mimics natural sunlight can improve brain activity, heart rate regulation, and movement in people who have had a stroke. Thirty chronic stroke survivors will undergo light sessions while their brain waves and heart rhy…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This trial investigates whether injecting Botox near a nerve bundle in the face, called the sphenopalatine ganglion, can reduce the number of severe headache days in people with chronic migraine that hasn't improved with other treatments. Participants receive either Botox or a pl…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. Fifty participants will receive ECT sessions with anesthesia, and researchers will m…

This pilot study tests whether manual lymphatic drainage, a gentle massage technique, can help people with migraine. Twenty adults aged 20-55 who have at least 4 migraines per month will receive either the massage or standard care. Researchers will measure pain, disability, and q…

This study tests whether online cognitive-behavioral therapy (CBT) for insomnia, combined with CBT for pain, can reduce headaches and improve sleep in adolescents aged 11-17 who have both migraine and insomnia. Participants receive internet-delivered programs focusing on sleep hy…

This study tests a new therapy that uses moving sounds to help stroke survivors with spatial neglect — a condition where they ignore one side of space. 18 participants will either get standard rehab or standard rehab plus dynamic auditory cueing for 4 weeks. The goal is to see if…

This study tests whether health education videos redesigned using semiotics—the science of signs and symbols—can help stroke survivors improve daily activities, sleep, anxiety, and depression. Two hundred stroke patients will be randomly assigned to watch either these optimized v…

This completed trial tested whether brief, moderate-to-vigorous physical activity sessions combined with health education could increase exercise in stroke survivors. 36 adults aged 50 and older who had a stroke and lived at home took part. Participants wore an accelerometer to t…

This study tests whether balance exercises that challenge the senses (like closing eyes or standing on uneven surfaces) can improve balance and reduce fall risk in people who had a stroke over 6 months ago. 46 participants will be split into two groups: one doing these special ex…

This study tested whether fast arm movement training helps people who had a stroke regain arm function better than standard accuracy training. 44 chronic stroke survivors with mild to moderate arm weakness participated. The training focused on moving quickly, and researchers meas…

This study tested whether adding mental practice of swallowing to standard therapy helps people who have trouble swallowing after a stroke. 43 adults were split into three groups: one watched swallowing videos then imagined the action, one just imagined swallowing, and one had on…

This study tested a new occupational therapy called HABIT, designed to help stroke survivors use their affected hand more in everyday activities. Eleven adults with mild hand weakness after stroke participated. Researchers measured hand use and satisfaction with daily tasks befor…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This study tested a mobile robot designed to help people who have had a stroke regain their ability to walk. 37 stroke survivors used the robot for 16 sessions along with their usual physical therapy. The goal was to see if the robot improved their balance and walking more than s…

This study tested whether combining somatotherapy (body awareness and movement exercises) with occupational therapy (training in daily tasks like dressing and cooking) could improve cognitive function in 50 adults who had a stroke. Participants received 35-minute sessions five da…

This study tested whether adding gentle sensory stimulation (like light touch and tapping) to standard physical therapy could improve facial symmetry and function in people with facial palsy after a stroke. Thirty-six participants were split into two groups: one received both sen…

This pilot study tested a wearable grasping neuroprosthesis in 6 people with hand weakness after a stroke. Participants used the device at home daily to help with gripping tasks. The study focused on how often people used it and whether it was practical and helpful in real life.

This study looked at 39 adults who had arm stiffness (spasticity) after a stroke. Researchers compared different types of transcranial magnetic stimulation (TMS) combined with Botox injections to see which worked best. The goal was to reduce muscle tightness and improve arm movem…

This study tested how well two approved migraine medications, ubrogepant (for acute attacks) and atogepant (for prevention), work together in real-world settings. 391 adults with migraine used both drugs as prescribed by their doctor for 30 days. The goal was to see if the combin…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This study tested whether a virtual reality shopping game could help stroke survivors improve their daily living skills. Twenty-nine adults who had a stroke 1 to 18 months earlier participated. One group practiced shopping in a virtual supermarket, while the other did standard co…

This study tested whether treating the greater occipital nerve on one side or both sides of the head with pulsed radiofrequency provides better migraine relief. 217 adults with episodic or chronic migraine who did not respond well to preventive medications received the procedure …

This pilot study tested whether adding virtual reality (VR) exercises to standard rehabilitation helps people who recently had a stroke recover their thinking skills and ability to do daily tasks. Thirty-six adults with acute stroke and mild cognitive impairment were assigned to …

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study looked at whether adding robot-assisted walking training to stationary cycling helps people who recently had a stroke and are losing muscle. 53 participants did either cycling alone or cycling plus robot walking for 4 weeks. The goal was to see if the combination impro…

This study tested whether a set of exercises called FAST (Fast muscle Activation and Stepping Training) can improve walking balance in people who had a stroke. 55 participants who had a first stroke within the past 6 months and had leg weakness took part. They did 12 sessions of …

This study tested whether 3 weeks of intensive language therapy (at least 2 hours daily, 5 days a week) helps people with long-term aphasia after a stroke communicate better in everyday situations. 156 participants with aphasia for at least 6 months were assigned to either immedi…

This study tested a powered hip exoskeleton for gait training in 32 people who had a stroke at least 3 months earlier. Participants used the device for 10 sessions over 5 weeks. The main goal was to check safety and see if walking speed improved.

This study tested a device called MyoRegulator® to see if it can reduce muscle stiffness (spasticity) in the lower leg after a stroke. 44 adults who had a stroke at least 6 months earlier took part. Half received real treatment and half received a sham (fake) treatment for 5 days…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study tested the safety and effectiveness of repeated MYOBLOC injections over one year in 187 adults with troublesome drooling caused by conditions like Parkinson's disease, stroke, or ALS. Participants received up to four treatment sessions, and researchers tracked side eff…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This study tested a new program called CATCHES for people who had a stroke and are afraid of falling. The program combines physical therapy at home with coaching to reduce fear. 30 adults who had a mild to moderate stroke took part. The goal was to see if the program is practical…

This study tested a device called recoveriX that uses a brain-computer interface, electrical stimulation, and virtual reality to help stroke survivors improve their walking. Thirty participants who had a stroke at least six months ago were split into two groups: one used the full…

This study tested whether mirror therapy can reduce pain and improve movement in stroke patients who also have complex regional pain syndrome (CRPS). Forty adults who had a stroke within the past year and were diagnosed with CRPS took part. They received either real mirror therap…

This study tested two methods to help people regain arm movement after a stroke: looking at a mirror to trick the brain, or using a robotic hand glove that mimics the healthy arm. Thirty adults who had a stroke within the past year took part. Both groups also received standard ph…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study looked at whether a mother's scent and a soft, knitted octopus toy could reduce pain in newborns who had a lack of oxygen at birth (asphyxia) and were receiving cooling treatment. The study included 45 full-term babies in intensive care. Researchers measured pain level…

This study tested a non-invasive brain stimulation technique called continuous theta-burst stimulation (cTBS) in 60 people who had a stroke within the past two weeks and had moderate to severe arm weakness. The stimulation was guided by brain scans to target areas involved in mov…

This study tested whether combining motor imagery (thinking about moving without actually moving) with a type of brain stimulation called TMS could help people who had a stroke regain arm function. 24 adults who had a stroke at least one month prior participated. The goal was to …

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This small pilot study tested whether a gentle electrical current applied to the brain (tACS) could improve naming ability in 11 people with chronic aphasia after a stroke. Participants received either real or sham stimulation during language training over two weeks. The goal was…

This study tested whether specialized sexual nursing care could help stroke patients and their partners manage sexual difficulties. Thirty stroke survivors and their partners were split into two groups: one received personalized counseling and education from trained nurses, while…

This study tested the drug erenumab in 512 adults who have frequent migraines (7 to 14 headache days per month) and had already tried at least one other preventive treatment that didn't work. The main goal was to see if erenumab could reduce the number of hours they spent with mo…

This study tested whether adding virtual reality (VR) exercises to standard home balance training helps people with vestibular migraine, a condition causing dizziness and balance problems. Forty adults with the condition were split into two groups: one did only home exercises, th…

This study tested whether repeated injections of a numbing drug (bupivacaine) into the back of the head could help people with chronic migraine or chronic tension-type headache. 290 adults received either the drug or a placebo (salt water) injection over three months. The main go…

This study looked at whether starting more frequent or intense physical therapy within the first day after a stroke helps patients regain movement and balance. 102 adults with acute stroke were split into groups receiving standard care, more sessions, harder exercises, or both. R…

This study looked at whether listening to self-chosen Italian music during and after a stroke hospital stay can improve mood, reduce anxiety and depression, and boost overall well-being. 150 stroke patients were randomly assigned to either regular music listening or standard care…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested whether using a video game called MindPod Dolphin is safe and practical for arm rehabilitation in people who recently had a stroke. 58 participants played the game, controlling a dolphin with their affected arm. The goal was to see if patients would stick with i…

This study tested a 12-week telehealth program for people with migraines, combining online modules, phone sessions, and a headache diary app. Twenty adults from a headache center in New York participated. The goal was to see if the program was feasible and acceptable, not yet to …

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blo…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study tested two ways to do extra arm exercises after a stroke: a custom program designed by a therapist, or using a special movable wheelchair armrest (called Boost). 35 people in acute rehab took part. The goal was to see which method better improves arm movement and reduc…

This completed study tested the EXOPULSE Mollii suit, a full-body garment with 58 electrodes, in 30 stroke survivors who had muscle stiffness (spasticity) and balance problems. The suit stimulates muscles to reduce spasticity and improve balance. Researchers measured balance chan…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study tested a device called Mi-Helper that cools the inside of the nose to treat migraine headaches at home. 156 adults with migraines used either the real device or a fake one. The goal was to see if the device could safely relieve pain and other bothersome symptoms within…

This study looked at whether giving children with migraine an IV of salt water (a common fluid) in the emergency room can help reduce their headache pain. 46 children took part. The goal was to see if the fluid alone, without any other medicine, could make them feel better.

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This Phase 3 trial tested a single dose of AXS-07, a combination of meloxicam and rizatriptan, for treating migraines in adults. 302 participants took either the drug or a placebo at the first sign of migraine pain. The study measured how many were pain-free and free of their mos…

This study tested two non-invasive treatments—high-intensity laser therapy (HILT) and extracorporeal shock wave therapy (ESWT)—to reduce calf muscle stiffness and improve walking in 39 people who had a stroke at least three months earlier. Both therapies aim to relax spastic musc…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study looked at how well and how safely lasmiditan works for treating migraine attacks. One hundred adults with migraine took lasmiditan tablets (50, 100, or 200 mg) when they had an attack. Researchers measured how many people were pain-free after 2 hours and tracked any si…

This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug le…

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested whether intensive upper limb rehabilitation helps people who had a stroke at least 6 months ago. 105 participants were randomly assigned to one of two intensive therapy programs or usual care. The goal was to see if high-dose training improves arm movement and f…

This study looked at whether different types of physical exercise can help adults recover from a mild traumatic brain injury (concussion). 37 adults who had a concussion within the past year took part in a 3-month program of either balance or aerobic exercises. Researchers measur…

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The trial's status is currently withheld, meaning key details about its progress and results are not publicly available. The purpose appears to be gathering information about th…

This study tests two leg devices—the geko® nerve stimulator and an intermittent pneumatic compression (IPC) sleeve—to see if they increase blood flow to the brain in people who recently had an ischemic stroke. Eighty adults within 36 hours of stroke onset will use one of the devi…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This completed study looked at how brain lesions from strokes impact cognitive control—the ability to focus, switch tasks, and make decisions. Researchers tested 184 healthy adults and stroke patients using behavioral tasks, brain scans (MRI), and EEG. The goal was to understand …

This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for pe…

This study used a non-invasive brain stimulation technique called TMS to measure how the motor cortex responds in people who have had a stroke. Researchers compared brain excitability between 24 stroke survivors and healthy individuals. The goal was to better understand how strok…

This observational study follows about 236 adults with diabetic macular edema (DME) who did not respond well to anti-VEGF injections and are now starting treatment with a dexamethasone implant (DEX-I). The implant slowly releases steroid medication into the eye. Researchers will …

This study looks at 100 people having a mechanical thrombectomy (clot removal) for a major stroke. Researchers will monitor their blood sugar continuously during the procedure and check recovery 3 months later. The goal is to see if lower blood sugar at the time of reperfusion (w…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study tested two advanced rehabilitation devices—a treadmill and an overground walking trainer—to help 80 stroke patients regain their ability to walk. Participants used either the C-Mill treadmill or the Andago overground device alongside standard therapy. The goal was to s…

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

Researchers at the University of Ioannina are studying stroke patients who have both movement and vision problems. They will evaluate each patient twice, once shortly after the stroke and again weeks later, to measure how these deficits change. The goal is to see whether improvem…

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study tests whether a practice resource called PReDAS helps occupational therapists who work with stroke patients feel more confident and make better decisions about driving. Eight occupational therapists on acute stroke units will receive the resource and a one-hour trainin…

This trial is testing whether an artificial intelligence (AI) tool can accurately predict how patients with acute ischemic stroke will recover. The AI analyzes patient data in real time to forecast outcomes, such as functional disability, which is then compared with the actual ou…

This study is testing whether an advanced ultrasound technique can identify which carotid artery plaques are dangerous (vulnerable) and likely to cause a stroke. Researchers will compare ultrasound images taken before surgery with the actual plaque tissue removed during the opera…

This completed study looked at how a person's total daily-life exposure—called the 'exposome'—affects health after a stroke. Researchers tracked 150 stroke survivors, measuring biological, environmental, social, and lifestyle factors alongside motor and cognitive tests. The goal …

This study tests whether a specialized training program called off-script diagnosis and differential diagnosis (D&D) training can improve neurology residents' ability to diagnose and manage acute ischemic stroke. The training focuses on structured analysis of stroke causes, mimic…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This study investigates how brain activity changes when people imagine moving their wrist. Researchers will use advanced brain scans (MRI and MEG) to create personalized models of these signals, then test if they can decode imagined movements using simpler EEG recordings. The goa…

This study investigates whether changes in a brain network called the default mode network (DMN) are linked to the nocebo effect — experiencing side effects from negative expectations rather than from a treatment itself. Researchers will use functional MRI to scan the brains of 4…

This study compares three devices that measure how well blood clots — ClotPro, ROTEM, and TEG — in patients undergoing liver surgery, neurosurgery, or cesarean section. The goal is to see how closely the results from these devices agree with each other. The findings may help doct…

This study looks at how certain immune cells (neutrophils) behave in people having a severe stroke. Researchers want to find the best time and target for treatments that block these cells. 440 adults having emergency stroke treatment will give blood samples and have their recover…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This study looked at why some people have trouble balancing while sitting after a stroke. Researchers used a special pressure-sensing pad and motion trackers to measure how 32 stroke survivors shifted their weight and moved their head and trunk. The goal was to better understand …

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach b…

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study looked at whether a substance in the blood called D-dimer can help predict how well people recover after a stroke. Researchers measured D-dimer levels in 102 stroke patients who had received treatment to restore blood flow. They then compared these levels with standard…

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study tested a new, powerful MRI scan on 56 stroke patients to see if it could detect subtle brain damage not visible on standard scans. The goal was to better understand how much brain tissue is truly saved after treatment. The findings could help doctors predict recovery m…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This study looked at 31 full-term newborns with brain injury from lack of oxygen (hypoxic-ischemic encephalopathy). Researchers used a special MRI technique called arterial spin labeling to measure blood flow in the brain during the first week of life. The goal was to see if this…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study looked at whether monitoring moderate diabetic retinopathy (an eye condition caused by diabetes) through tele-expertise (remote specialist review) works as well as the usual in-person eye doctor visits. Researchers followed 97 patients with diabetes and moderate retino…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This study looked at 232 people with cerebral venous thrombosis, a rare stroke that mainly affects young women. Researchers took blood samples at several time points to measure markers of clot formation and breakdown. They wanted to see if these markers relate to how the disease …

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This study translated the Fugl-Meyer assessment, a test that measures movement and function after a stroke, into Turkish and checked if it works correctly. Researchers tested 80 stroke patients in Turkey to see if the Turkish version is reliable and accurate. The goal was to give…

This study asked stroke survivors, caregivers, and healthcare professionals what they need from a home-based rehabilitation system called NEST. The system includes an exercise app, a smartwatch, and a virtual coach. Researchers held focus groups and interviews in Italy, Spain, an…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study tested whether a special PET scan can predict delayed brain damage in people who had a bleeding stroke from a burst aneurysm. 35 participants received a PET scan within days of their stroke to measure how their brain cells take up sugar, which reflects blood flow. The …

This study observed 141 people in German stroke units who had a brain bleed while taking the blood thinners rivaroxaban or apixaban. Researchers wanted to see if giving the reversal drug andexanet alfa could stop the bleed from getting bigger. They tracked changes in bleed size o…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at what makes it easier or harder for veteran stroke survivors to do arm and hand exercises at home. Researchers gave surveys about mood, confidence, and sleep, then used a wearable tracker to measure exercise. The goal is to find ways to help people stick with …

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used gentle leg movements and muscle contractions to measure blood flow. The goal was to learn more about why stroke survivors often have reduced exerc…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study looked at how the brains of people with aphasia (a language disorder after stroke) and healthy people work together during gestures. Using EEG, researchers measured brain synchronization while participants watched and copied different types of gestures. The goal was to…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study compared two types of anesthesia—propofol alone versus a mix of propofol and ketamine—in 46 adults having elective surgery for unruptured brain aneurysms. Researchers measured the diameter of the optic nerve sheath (a marker of brain pressure) at several points during …

This study followed 82 people with blocked arteries supplying the back of the brain to see if low blood flow raises the risk of stroke or mini-stroke. Participants had already experienced a stroke or transient ischemic attack (TIA) and had at least 50% blockage in those arteries.…

This study tested whether wrist-worn accelerometers can accurately measure how much stroke patients use their weaker arm during everyday activities like dressing and eating. Twenty-five participants were recorded with both accelerometers and video cameras. The goal was to see if …

This study looked at 55 stroke survivors to see if reducing sitting time early after stroke helps with walking and daily function. Researchers also checked if brain scan markers can predict who benefits most from rehab. The goal is to create personalized recovery plans based on e…

This study looked at how migraine patients and healthcare providers in Thailand experience eptinezumab, a preventive migraine infusion given every 3 months. Researchers interviewed 30 participants to find out what makes it easier or harder to use this treatment in a real-world ho…

This study tested whether a 1-minute 51-second animated video called FAST BEE helps people learn and remember stroke warning signs. Over 300 healthy adults and teens watched the video and then answered questions about what they learned. The goal was to see if the video improves r…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This study looked at 70 people who had a brain hemorrhage (bleeding stroke) to see if a special PET scan could tell whether the bleeding was caused by amyloid buildup in blood vessels or by high blood pressure. Participants received an injection of a radioactive tracer called Flo…

This completed study followed over 31,000 people in China who had unruptured brain aneurysms (a bulge in a blood vessel that hasn't burst). Researchers compared four approaches: simply monitoring the aneurysm, surgical clipping, coil embolization, or flow diversion. The goal was …

This study checked how well the Fugl-Meyer Assessment (a test for stroke recovery) works in people recovering from a stroke. Over 100 patients in rehab were tested when they arrived and when they left. The goal was to see if the test accurately tracks improvement.

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This completed study looked at how leg muscles work during walking in 500 people who had a stroke. The goal was to understand muscle patterns, test how well current measurement methods work, and find early signs that predict walking recovery. The results could help doctors create…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This study looked at how doing a thinking task while walking affects the brain in people who have had a stroke. Eleven stroke survivors walked on a special mat while a brain scanner measured their brain activity. The goal was to understand why walking gets harder when you have to…

This study tested a program to help people with stroke or TIA transition from hospital to home. 213 participants received either the program or usual care. The program focused on improving communication, health literacy, and medication management. Researchers measured quality of …

This study worked with 49 stroke patients, their families, and healthcare teams to design and test a more personalized way to move from the hospital to home rehabilitation. The goal was to improve the quality of care transitions and health literacy. The study did not test a treat…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study tested whether a special MRI scan called IVIM can predict how well people recover three months after an acute ischemic stroke. Researchers added a two-minute scan to the standard MRI for 274 adults admitted with stroke. They then compared the scan results to the patien…

This study looked at 174 adults who had a stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better functional recovery after 90 days. The goal is to find the best time to take patie…

This study tested whether raising the legs (elevated leg positioning) is safe and practical for people who have had a moderate ischemic stroke. Fifty adults with moderate stroke symptoms were enrolled within 24 hours of symptom onset. The goal was to see if this simple, non-drug …

This study looked at 70 family caregivers of stroke patients who also have bladder issues. Researchers measured how much burden, fatigue, poor sleep, and depression caregivers experience. The goal was to understand the challenges these caregivers face, not to test a new treatment…

This study looked at 50 people who had a mild stroke to understand why they might struggle with everyday activities like work, hobbies, or socializing. Researchers wanted to see if factors like mood, fatigue, or thinking problems make these gaps worse, and if having more gaps low…

This study tested whether telephone interviews after a stroke can help patients better understand and follow their medication plans. 54 adults who had an ischemic stroke and were returning home received a pharmaceutical interview before discharge, followed by phone calls at one w…

This study looked at brain activity in 64 people (some who had a stroke and some healthy) while they moved their arms with different levels of effort. The goal was to understand how the brain responds during rehabilitation exercises. Researchers used a special brain scanner (fNIR…

This study measured levels of a brain protein called BDNF in 50 stroke patients who received a clot-busting drug. Researchers wanted to see if BDNF levels rise after treatment and if they could help predict recovery of movement, thinking, and mood three months later. The goal is …

This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells.…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study looked at over 1,600 people with giant cell arteritis, a condition that inflames blood vessels and raises heart risks. Researchers compared tocilizumab and methotrexate to see which better prevents heart attacks, strokes, or death. Using French health data, they analyz…

This study looked at 1499 people who had an acute ischemic stroke and got a chest CT within 24 hours. Researchers wanted to see if combining CT findings with clinical signs and inflammation markers could better predict who would develop pneumonia within a week. They built and tes…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 167 people with atrial fibrillation or flutter who had a catheter ablation procedure. Researchers measured changes in stroke and bleeding risk scores before and 3, 6, and 12 months after ablation. They also compared different monitoring methods, including impl…

This first-in-human study tested a new smart guidewire (Clotild®) in 45 stroke patients undergoing emergency clot removal. The wire helps guide the removal tool and also measures the clot's electrical properties to determine its composition. The main goal was to check safety, suc…

This study checked if a Turkish version of the Bolus Residue Scale (BRS) is a reliable way to measure swallowing problems in people who recently had a stroke. Researchers looked at video recordings of 40 patients swallowing and had experts rate the results. The goal was to make s…

This completed study involved over 36,000 patients and aimed to create quality indicators for stroke and chronic coronary syndrome care using French national health databases. Researchers linked patient data from practice registries to the national database to validate these indi…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study looked at 53 adults having ear surgery (tympanoplasty) with their head turned to the side. Doctors used ultrasound to measure the optic nerve sheath diameter, which can indicate pressure inside the skull. The goal was to see if the sideways head position changes that p…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This study looked at 126 people who recently had a stroke caused by a blocked blood vessel in the brain. Researchers wanted to find out how common fatigue is after a stroke and what factors might be linked to it, including any treatments given in the first days. Participants comp…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study looked at blood samples from 41 people with giant cell arteritis (Horton's disease), a condition that causes inflammation in blood vessels. Researchers examined specific immune cells called regulatory T cells to see if they are defective in this disease. The goal is to…

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …

This study looked at whether doctors, nurses, or standard risk scores are better at predicting long-term recovery after a brain hemorrhage. Over 1,000 patients were followed for 6 months. The goal is to improve how we estimate outcomes for these serious conditions.

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study aimed to better understand why some people develop delayed brain damage after a brain aneurysm rupture. Researchers measured platelet activation over time in 90 patients, comparing those with aneurysm bleeds to those with other types of brain bleeds. The goal was to cl…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study examined whether certain genes are linked to a severe form of diabetic eye disease called proliferative diabetic retinopathy (PDR). Researchers analyzed DNA from 302 people with type 2 diabetes, some with PDR and some without. The goal was to find genetic markers that …

This study tested a new way to assess and train balance using a reaching task. Seven people, including stroke survivors and healthy adults, took part. They stood and pointed at a moving target on a screen, which challenged their balance. The goal was to see if this method could s…

This study looked at whether ivabradine, a medicine used for heart conditions, could stop migraines triggered by another drug called levcromakalim. 37 adults with migraine without aura took part. The goal was to see if ivabradine could reduce the number of migraines caused by the…

This study looked at how the brain responds when people exercise while breathing low-oxygen air (like at high altitude). Thirty healthy men did exercise tests while researchers measured brain and muscle activity using special scans and stimulation. The goal was to understand why …

After a stroke, many people can move their affected arm but choose not to, a condition called non-use. This study tested 53 participants (stroke survivors and healthy controls) to see how the need for force or precision affects arm use. Researchers used a weight-support system to…

This study observed 20 stroke patients with hemiplegia (weakness on one side) as they walked 10 meters. Researchers used sensors and a special walkway to measure foot movements and timing. The goal was to gather data that could help improve when functional electrical stimulation …

This study looked at 366 people who had a brain bleed from a burst aneurysm. Researchers measured hemoglobin in the fluid around the brain and spine to see if it could predict secondary brain injury, like artery spasms or lack of blood flow. The goal is to find a better way to mo…

This study looked at 40 stroke patients with arm muscle stiffness (spasticity) who were treated with botulinum toxin (Botox). Researchers measured tiny electrical signals in the muscle to see how they change over time and whether they relate to how well the treatment works. The g…

This study used a special eye-imaging technique called adaptive optics to look at tiny blood vessels in the retina of people who recently had a stroke. Researchers compared these images to those from healthy individuals to see if the blood vessel structure differs. The goal was t…

This study looked at 15 stroke patients with a condition called cerebral amyloid angiopathy (CAA), which makes blood vessels in the brain fragile and prone to bleeding. All patients received a clot-busting drug (thrombolysis) and were checked for brain bleeding 24 hours later. Re…

This study looked at brain scans from 315 people with two types of small vessel disease: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). Researchers wanted to see if the pattern of white matter changes around the brain's fluid-filled spaces could help tell t…