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Brain protection during carotid surgery: new procedure shows promise

NCT ID NCT06359756

Prevention Sponsor: Institute for Cardiovascular Diseases Dedinje Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed clinical trial tested a procedure called ischemic postconditioning to prevent brain damage in 40 people undergoing carotid surgery for severe artery narrowing. The procedure involves briefly clamping and unclamping the carotid artery in cycles after surgery to protect the brain. Researchers measured brain oxygen levels, blood flow, and markers of brain injury to see if the technique is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ischemic postconditioning (a procedure involving brief cycles of clamping and unclamping the carotid artery during surgery)
What this could lead to
If this procedure proves effective, it could offer a simple way to reduce the risk of stroke and brain damage during carotid surgery.
What could go wrong
This is a very small, completed trial with only 40 participants, so results may not apply to everyone. The procedure itself involves temporary clamping of the artery, which carries its own risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * unilateral carotid artery stenosis \>90% * bilateral stenosis \>80% * unilateral stenosis \>80% with contralateral occlusion/subocclusion Exclusion Criteria: * urgent carotid endarterectomy * carotid restenosis * "major surgery" in the last 6 months * malignant diseases * previous brain trauma or surgery * epilepsy

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Conditions

The condition(s) this trial relates to.

carotid artery disorder carotid stenosis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery diseases Carotid surgery Ischemic postconditioning Stroke

Contacts and locations

Locations

  • Institute for Cardiovascular Diseases Dedinje

    Belgrade, 11000, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.