New combo therapy eases stroke arm stiffness
NCT ID NCT07624149
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 39 adults who had arm stiffness (spasticity) after a stroke. Researchers compared different types of transcranial magnetic stimulation (TMS) combined with Botox injections to see which worked best. The goal was to reduce muscle tightness and improve arm movement and daily activities.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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39 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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May 2026
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of stroke (ischemic or hemorrhagic) * Time since stroke onset between 3 and 24 months * Age between 18 and 80 years * Upper extremity motor recovery at Brunnstrom Stages 3-5 * Spasticity in the elbow, wrist, or finger flexor muscle groups of the upper extremity with a Modified Ashworth Scale (MAS) score between +1 and 3 * Receipt of botulinum toxin-A injection to the affected upper extremity within the previous week Exclusion Criteria: * History of epileptic seizures, epileptiform EEG findings, increased seizure risk, or use of antiepileptic medication * Presence of implanted metallic or electronic devices (e.g., cardiac pacemaker, intrathecal baclofen pump) * Pregnancy or lactation * Presence of neurological disorders other than stroke * History of cranial surgery * Orthopedic conditions or previous orthopedic surgery limiting upper extremity movement * Severe upper extremity spasticity (MAS \>3) or presence of contracture * Uncontrolled hypertension, advanced heart failure (NYHA Class III-IV), chronic obstructive pulmonary disease (COPD), active infection, severe hepatic failure, or severe renal failure * History of malignancy * Severe cognitive impairment (Mini-Mental State Examination score \<24) * Severe aphasia or communication disorder that would interfere with participation in the study * Botulinum toxin injection administered to the upper extremity in a separate treatment session within the previous 3 months * Any change in medication type or dosage within the previous month for oral medications used in the management of spasticity
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ankara Etlik City Hospital, Physical Medicine and Rehabilitation Clinic
Ankara, Ankara, 06010, Turkey (Türkiye)