Scientists investigate immune cells in Horton's disease
NCT ID NCT02158208
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells. The goal was to gather information, not to test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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30 people
The number who actually took part.
- Started
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Jul 2013
- Finished
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Jan 2016
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients presenting Horton's disease at the diagnosis before any treatment
- Ages
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50 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients * Patients who have provided written informed consent * Patients covered by national health insurance * Age \> 50 years * Patients with Horton's disease at the diagnosis before any treatment Horton's disease is defined by American College of Rheumatology criteria, the diagnosis is made if any 3 of the following 5 criteria are associated: * age at the onset of the disease 50 years or above * recent onset localised headache * indurated temporal artery or decrease/absence of temporal pulse * erythrocyte sedimentation rate (ESR) above 50 mm for the first hour (or CRP\>20 mg/L) * positive TAB showing vascularitis with infiltration of mononucleated cells or granulomatous inflammation with or without giant cells. Controls Controls will be healthy volunteers recruited from blood donors of Dijon CHU, voluntary hospital personnel (nurses, doctors, laboratory technicians and secretaries) and patients without infectious or inflammatory disease, cancer or auto-immune disease (CRP\<5mg/L) recruited in the department of the investigators at Dijon CHU. They will be matched for age and sex. * Age \> 50 years * Patients covered by national health insurance * who have provided written informed consent to take part * Absence of inflammatory syndrome (CRP\<5 mg /L) Exclusion Criteria: * Any patient not meeting inclusion criteria * Patient treated with corticoids or immunosuppressants in the month preceding inclusion * Patients treated with chemotherapy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de DIJON
Dijon, 21079, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.