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New hope for migraine sufferers? Needle-Freezing technique targets pain hub

NCT ID NCT07370142

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses a short burst of energy to calm the nerve without damaging it. Researchers measured pain levels, quality of life, and medication use over six months to see if the treatment provides lasting relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pulsed radiofrequency procedure
What this could lead to
If successful, this could offer a safe, non-drug option for long-term pain relief in people with hard-to-treat craniofacial pain.
What could go wrong
This is a small, single-center study with no control group, so results may not apply broadly. Pain relief may vary or be temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Mar 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years and older (no upper age limit) * Patients diagnosed with refractory chronic headache (including cluster headache, migraine, paroxysmal hemicrania, hemicrania continua, SUNCT, or SUNA) or chronic orofacial pain / trigeminal neuralgia * Pain duration of at least 3 months * Pain intensity score (VAS or NRS) \> 3 out of 10 * Patients unresponsive to conservative medical treatments * Patients scheduled for sphenopalatine ganglion (SPG) pulsed radiofrequency (PRF) treatment as part of routine clinical care * Ability and willingness to provide written informed consent Exclusion Criteria: * Systemic infection or local skin infection at the needle insertion site * Known coagulopathy or bleeding disorders * Presence of a cardiac pacemaker or implantable cardioverter-defibrillator (ICD) * Presence of an intracranial mass or significant anatomical distortion in the pterygopalatine fossa region * Previous surgical intervention involving the sphenopalatine ganglion * Pregnancy or breastfeeding * Severe psychiatric or cognitive disorders preventing reliable pain assessment or follow-up * Hemodynamic instability * Refusal to participate in the study or undergo the procedure

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome Facial Pain headache disorder hemicrania continua migraine disorder paroxysmal Hemicrania SUNCT syndrome trigeminal autonomic cephalalgia trigeminal neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine disorders, facial pain disorder, cluster headache, trigeminal neuralgia, trigeminal autonomic cephalalgias

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    Ankara, Ankara, 06800, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.