Blood sugar rollercoaster linked to stroke death risk
NCT ID NCT04001049
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand whether unstable blood sugar predicts poorer recovery, which could guide future treatment strategies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors understand which stroke patients need tighter blood sugar control to improve survival and recovery.
- What could go wrong
- This is an observational study, not a treatment trial. It cannot prove that controlling blood sugar directly improves outcomes, only that a link may exist.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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192 people
The number who actually took part.
- Started
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Jun 2020
- Finished
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Dec 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients \> 18 years old presenting with acute ischemic stroke of less than 24 hours of evolution
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \> 18 years old * Inclusion less than 24 hours from ischemic stroke * Functional independence prior to stroke * Signed informed consent Exclusion Criteria: * Transient cerebral ischemia * Prevision of need to perform a magnetic resonance within the first 96 hours from inclusion * Concomitant severe or deadly disease that may interfere with study follow-up during 3 months from stroke * Current drug or alcohol abuse that may interfere with study follow-up * Participation in a clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Universitario La Paz
Madrid, 28046, Spain
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