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Brain zaps and therapy show promise for kids with stroke paralysis

NCT ID NCT03216837

Disease control Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes in how well they used their affected hand in daily tasks. The goal is to find a new, non-drug treatment to help these children gain more independence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cathodal transcranial direct current stimulation (tDCS)
What this could lead to
If it works, this could offer a new, non-invasive way to improve hand function and quality of life for children with hemiplegic cerebral palsy after perinatal stroke.
What could go wrong
This is a completed early-stage trial with 89 participants, so results may not apply to all children. The treatment requires precise brain mapping and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

89 people

The number who actually took part.

Started

Jul 2017

Finished

Mar 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinical and MRI confirmed perinatal ischemic stroke (NAIS, APPIS, PVI) 2. Symptomatic hemiparetic CP including parent/child perceived limitations in function 3. Able to briefly lift light object off a surface (estimated House class 3-6). 4. Informed child consent/assent and parental/guardian consent Exclusion Criteria: 1. Other neurological disorder not related to perinatal stroke 2. Multifocal stroke 3. Severe hemiparesis (no voluntary contraction, MACS V) 4. Sever spasticity (Modified Ashworth Scale \>3) 5. Severe delay or inability to comply with protocol 6. Unstable epilepsy 7. TMS or MRI contraindication 8. Orthopedic surgery, constraint, brain stimulation or other modulatory therapy in past 6 months prior to camp day 1 9. Botulinum toxin injections in past 4 months prior to camp day 1

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Conditions

The condition(s) this trial relates to.

cerebral palsy spastic hemiplegic hemiplegia pediatric arterial ischemic stroke spastic hemiplegia stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemiplegic cerebral palsy Perinatal stroke

Contacts and locations

Locations

  • University of Calgary

    Calgary, Alberta, T2M 1N4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.