Stroke patients get double Anti-Clot therapy in landmark trial

NCT ID NCT06316570

Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving two blood thinners (ticagrelor and aspirin) early, along with standard clot-busting treatment, helps people recover better after a stroke. Over 1,300 patients with mild to moderate stroke were treated within 6 hours of symptoms. The goal was to see if more patients could achieve a near-full recovery (no significant disability) at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: ticagrelor and aspirin
What this could lead to: If successful, this combination could become a new standard treatment to help more stroke patients recover with little or no disability.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. Adding two blood thinners may raise bleeding risk, and benefits may not apply to all stroke types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,382 people

The number who actually took part.

Started

Apr 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. 18-80 years old; 2\. Clinical diagnosis of acute ischemic stroke; 3\. Time from onset to treatment ≤6.0 hours; 4\. Having received or planning to receive intravenous thrombolytic therapy; 5\. NIHSS score of 4-10 points, and at least one of the 5th (upper limb exercise) or 6 th (lower limb exercise) scale is ≥1 point; 6\. Signed informed consent. Exclusion Criteria: * 1\. Planning to receive endovascular therapy; 2\. mRS scores ≥2 points before the onset; 3\. Receiving any antiplatelet therapy after the onset; 4\. Bleeding or other pathological brain disorders, such as vascular malformations, tumors, abscesses, or other common non-ischemic brain diseases (such as multiple sclerosis), identified by CT/MRI; 5\. Pre-existing clotting disorders, systemic bleeding, thrombocytopenia, or neutropenia; 6\. Pre-existing atrial fibrillation or anticoagulant therapy (warfarin, heparin, thrombin inhibitors or factor Xa inhibitors); 7\. Hepatic or renal insufficiency (hepatic insufficiency refers to the alanine transaminase (ALT) value \> 2 times the upper limit of normal value or aspartate aminotransferase (AST) times \> 2 times the upper limit of normal value; renal insufficiency refers to creatinine values \> 2 times the upper limit of normal value); 8\. Allergic to Ticagrelor or Aspirin or thier components and excipients; 9\. Women who are pregnant or breastfeeding, or those with negative pregnancy test records while refusing to use effective contraceptives; 10\. Having participated investigational drugs or device tests within 30 days; 11\. Being considered inappropriate to participate by researchers.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic stroke, acute

Contacts and locations

Locations

Affiliated Hospital of North China University of Science and Technology

Tangshan, Hebei, China
Anshan Changda Hospital

Anshan, Liaoning, China
Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China
Benxi Central Hospital

Benxi, Liaoning, China
Chenzhou First People's Hospital

Chenzhou, Hunan, China
Chenzhou Fourth People's Hospital

Chenzhou, Hunan, China
Dalian Lvshun district people's hospital

Dalian, Liaoning, China
Dalian University Affiliated Xinhua Hospital

Dalian, Liaoning, China
Dandong Central Hospital

Dandong, Liaoning, China
Henan Sui County Hospital of Traditional Chinese Medicine

Shangqiu, Henan, China
Henan Wenxian People's Hospital

Jiaozuo, Henan, China
Heyuan City Hospital of Traditional Chinese Medicine

Heyuan, Guangdong, China
Huangpi District People's Hospital of Wuhan City

Wuhan, Hubei, China
Jiaozuo People's Hospital

Jiaozuo, Henan, China
Jiyuan Hospital of Traditional Chinese Medicine

Jiyuan, Henan, China
Kaifeng Central Hospital

Kaifeng, Henan, China
Lankao County Hospital of Traditional Chinese Medicine

Kaifeng, Henan, China
Linfen Central Hospital

Linfen, Shanxi, China
Linfen People's Hospital

Linfen, Shanxi, China
Lingbao First People's Hospital

Henan, Sanmenxia, China
Linxi County People's Hospital

Xingtai, Hebei, China
Linyi City People Hospital

Linyi, Shandong, China
Liuyang Jili Hospital

Changsha, Hunan, China
Luoyang First People's Hospital

Luoyang, Henan, China
Luoyang Mengjin People's Hospital

Luoyang, Henan, China
Ningjin County Hospital of Hebei Province

Xingtai, Hebei, China
Puyang Anyang District Hospital

Anyang, Henan, China
Qi County Traditional Chinese Medicine Hospital

Kaifeng, Henan, China
Qinghe People's Hospital

Xingtai, Hebei, China
Qixian People's Hospital

Kaifeng, Henan, China
Renze District People's Hospital

Xingtai, Hebei, China
Sanmenxia Hospital of the Yellow River, Affiliated to Henan University of Science and Technology

Sanmenxia, Henan, China
Song County People's Hospital

Luoyang, Henan, China
Suixian People's Hospital

Shangqiu, Henan, China
The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Neimenggu, China
The Fifth Affiliated Hospital, Sun Yat-sen University

Zhuhai, Guangdong, China
The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Affiliated Hospital of Hebei North University

Zhangjiakou, Hebei, China
The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, Henan, China
The First Afflicted Hospital of Shihezi University

Shihezi, Xinjiang, China
The First Hospital of Fangshan District

Beijing, Beijing Municipality, China
The First People's Hospital of Shenyang

Shenyang, Liaoning, China
The People's Hospital of Weishi

Kaifeng, Henan, China
Tianjin Xiqing Hospital

Tianjin, Tianjin Municipality, China
Tuquan People's Hospital

Hinggan, Inner Mongolia, China
Weihai Wendeng District People's Hospital

Weihai, Shandong, China
Weinan Central Hospital

Weinan, Shanxi, China
Weishi Central Hospital

Weishi, Henan, China
Weishi County Central Hospital

Weishi, Henan, China
West China Hospital of Sichuan University

Chengdu, Sichuan, China
Wuming Hospital of Guangxi Medical University

Nanning, Guangxi, China
Xiangfu District First People's Hospital

Kaifeng, Henan, China
Xingtai Ninth Hospital

Xingtai, Hebei, China
Yangyuan County People's Hospital

Zhangjiakou, Hebei, China
Yantai Penglai Traditional Chinese Medicine Hospital

Dengzhou, Shandong, China
Yuci District People's Hospital

Jinzhong, Shanxi, China
Yulin First People's Hospital

Yulin, Guangxi, China
Zhalantun City Hospital of Chinese and Mongolian Medicine

Hulunbuir, Inner Mongolia, China
Zibo Municipal Hospital

Zibo, Shandong, China

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