Can a Rapid-Acting clot blocker boost stroke recovery?
NCT ID NCT07760922
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stroke onset. The study measures how many people achieve a good functional outcome at 90 days, while also monitoring for bleeding complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tirofiban (a blood-clotting blocker) given intravenously, combined with aspirin
- What this could lead to
- If it works, this could offer a new treatment option to improve functional recovery and reduce disability after moderate ischemic stroke.
- What could go wrong
- The trial is still testing the approach, and there is a risk of bleeding in the brain, a serious side effect. Results may not confirm a clear benefit over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 1,168 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18-80 years; 2. Acute ischemic stroke; time from last known well to randomization ≤ 24 hours; 3. Pre-randomization NIHSS score 4-10, with at least one of item 5 (upper limb) or item 6 (lower limb) ≥ 1; 4. Pre-stroke modified Rankin Scale (mRS) ≤ 1; 5. Written informed consent provided by the patient or a legally authorized representative. Exclusion Criteria: 1. Intracranial hemorrhage confirmed by CT or MRI; 2. Has received or is planned to receive reperfusion therapy (thrombolysis or endovascular treatment); 3. Any definite cardioembolic source: chronic/paroxysmal atrial fibrillation, sick sinus syndrome, mitral stenosis, mechanical heart valve, endocarditis, intracardiac thrombus or vegetation, myocardial infarction within 3 months, dilated cardiomyopathy, left atrial spontaneous echo contrast, ejection fraction \< 30%; 4. Definite indication for anticoagulation (atrial fibrillation, mechanical heart valve, deep vein thrombosis, pulmonary embolism); 5. Severe systemic disease (e.g., severe infection, severe hepatic or renal dysfunction); 6. Allergy to tirofiban and/or aspirin; 7. History of intracranial hemorrhage; 8. Planned use of NSAIDs affecting platelet function; 9. Gastrointestinal bleeding or major surgery within the past 3 months; 10. Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months; 11. Planned surgery or intervention requiring discontinuation of antiplatelet therapy; 12. Stroke caused by angiography or surgery; 13. Prior non-atherosclerotic arterial disease, including moyamoya disease, arterial dissection, fibromuscular dysplasia; 14. Other structural brain disease (vascular malformation, tumor, abscess, multiple sclerosis, etc.) confirmed by CT/MRI; 15. Pregnancy or lactation; 16. Prior neurologic or psychiatric disease that would interfere with neurologic assessment; 17. Participation in another clinical trial; 18. Advanced disease with expected survival \< 6 months; 19. Expected inability to complete follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The First Affiliated Hospital of Gannan Medical University
Nanchang, Jiangxi, 341000, China
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The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, 570000, China
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The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 341000, China
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The First People's Hospital of Jingdezhen City
Jingdezhen, Jiangxi, 341000, China
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The First People's Hospital of Jiujiang City
Jiujiang, Jiangxi, 341000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI as a second opinion for stroke: a smarter path to Clot-Busting?
- Can an earthworm enzyme boost stroke recovery?
- Can a common antibiotic shield the brain after a stroke?
- Can a simple relaxation technique soothe the mind after a stroke?
- Stroke care at a distance: can video consultations speed up Life-Saving treatment?
- Herbal capsule may boost brain repair after stroke