Clot removal vs. meds: which works better for mild stroke?
NCT ID NCT06778226
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a procedure to remove a blood clot from the brain (endovascular therapy) works better than medication alone for people with mild stroke symptoms and a visible clot. About 4,800 adults with mild stroke were included. The goal was to see which approach leads to better recovery and fewer complications.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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4,827 people
The number who actually took part.
- Started
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Jan 2018
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All acute stroke patients treated at participating sites in North America, South America, Europe, Asia, and Australia.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Acute ischemic stroke in an adult patient (18 years of age or older). 2. Onset (Last Seen Normal) time to treatment time \<24 hours or unknown Last Seen Normal in whom Endovascular Therapy could be considered per local radiographic guidelines. 3. Mild stroke defined as an NIH Stroke Scale ≤ 5 at the time of treatment decision. a. Patients with NIH Stroke Scale=0 can be included in the study if they have relevant abnormalities on neurological exam. 4. An acute intracranial vessel occlusion (Intracranial Internal Carotid Artery terminus (T or L clot), Middle Cerebral Artery (M1, M2, M3/beyond), Anterior Cerebral Artery (A1, A2, A3), V4, Basilar, Posterior Cerebral Artery) defined by non-invasive acute imaging (Computed Tomography, angiography (Computed Tomography Angiography) or Magnetic Resonance angiography (MRA)) that is neurologically relevant to the presenting symptoms and signs. Exclusion Criteria: 1. Stroke symptoms due to another non-ischemic acute neurological condition such as seizure with Post-ictal Todd's paralysis or focal neurological signs due to severe hypo- or hyperglycemia. 2. Hyperdensity on Non-contrast Computed Tomography consistent with intracranial hemorrhage. Any clinical suspicion of any intracranial hemorrhage even in the absence of visible blood on baseline brain imaging. 3. Large acute stroke \>1/3 Middle Cerebral Artery territory or Alberta Stroke Programme Early CT score (ASPECTS\<6 or established frank hypodensity relevant to the presenting acute stroke already visible on baseline CT scan. 4. Findings on acute CT or MRI to suggest that the 5. Patient has a severe or fatal or disabling illness that will impact decision regarding acute reperfusion therapies. 6. Pregnancy. 7. Clinical history, past imaging and clinical judgment suggest that the intracranial occlusion is chronic. 8. Stroke occurred as an inpatient. 9. Inclusion into any randomized control trials.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Brown University
Providence, Rhode Island, 02912, United States
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University of Miami
Miami, Florida, 33136, United States
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