Could simply raising your legs improve stroke recovery?
NCT ID NCT07483580
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether raising the legs (elevated leg positioning) is safe and practical for people who have had a moderate ischemic stroke. Fifty adults with moderate stroke symptoms were enrolled within 24 hours of symptom onset. The goal was to see if this simple, non-drug approach could improve blood flow to the brain and gather information for a larger future trial.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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May 2025
- Finished
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Dec 2025
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years. * Acute ischemic stroke (AIS) confirmed by cranial computed tomography (CT) or magnetic resonance (MR) imaging. * Time from onset (symptom onset or last known well) to enrollment of ≤24 hours. * Moderate neurological deficit (National Institutes of Health Stroke Scale \[NIHSS\] score of 6-16). * Probable large artery atherosclerosis (LAA )etiology based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria (confirmed by cranial CT or MR angiography and carotid duplex ultrasonography performed on admission). * Evidence of unilateral stenosis or occlusion of the internal carotid artery (ICA) or the M1 or proximal M2 segment of the middle cerebral artery (MCA) corresponding to the presumed culprit artery. * Functional independence prior to stroke (modified Rankin Scale \[mRS\] score ≤1). * Written informed consent signed by the patient or their legally authorized representative. Exclusion Criteria: * Decreased level of consciousness (NIHSS item 1a ≥1). * Planned or completed intravenous thrombolysis and/or endovascular therapy. * Planned carotid or intracranial revascularization within 3 months. * Evidence of intracranial hemorrhage on neuroimaging. * Alternative stroke etiologies (e.g., cardioembolism, non-atherosclerotic arteriopathies). * Serious systemic illness (e.g., significant hepatic or renal insufficiency, active malignancy). * Prior stroke with significant residual neurological deficit (mRS ≥2). * History of intracerebral hemorrhage within the preceding 12 months. * Any possible contraindication to ELP (e.g., active vomiting, pneumonia, uncontrolled heart failure). * Participation in another clinical trial within the preceding 3 months. * Pregnancy or lactation. * Any other condition deemed inappropriate for participation by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Jose R. Reyes Memorial Medical Center
Manila, NCR, 1003, Philippines
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