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Breathing settings during surgery may impact brain pressure, study finds

NCT ID NCT06979999

Knowledge-focused Sponsor: Nigde Omer Halisdemir University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 adult patients. The goal was to understand how breathing settings affect the brain during minimally invasive abdominal procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help anesthesiologists better manage breathing settings during surgery to protect the brain.
What could go wrong
This is a small, completed study with only 34 participants, so results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

May 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Adult patients (age ≥ 18 years) American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective laparoscopic cholecystectomy under general anesthesia Signed informed consent Exclusion Criteria: * resence of acute or chronic eye disease Uncontrolled hypertension Asthma or known chronic pulmonary disease Any neurological disorders Body mass index (BMI) \> 35 kg/m² Use of medications known to affect intracranial pressure Refusal to participate after signing informed consent

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Conditions

The condition(s) this trial relates to.

intracranial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracranial pressure Mechanical ventilation Optic nerve sheath diameter Positive end-expiratory pressure (PEEP)

Contacts and locations

Locations

  • Niğde Training and Research Hospital

    Niğde, Niğde Province, 5200, Turkey (Türkiye)

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