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New stroke clot removal technique could boost recovery rates

NCT ID NCT02523261

Disease control Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to remove large blood clots from the brain during a stroke: direct aspiration (ADAPT) and using a stent retriever. About 381 adults with stroke caused by a blocked artery in the front part of the brain took part. The goal is to see which method clears the blockage more completely and safely, potentially improving patients' recovery and reducing long-term disability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
direct aspiration procedure (ADAPT) and stent retriever procedure
What this could lead to
If ADAPT proves superior, it could become the preferred first-line technique for removing large clots in stroke patients, leading to better recovery and less disability.
What could go wrong
This is a completed study, but results may not apply to all stroke types or settings. The techniques are invasive and carry risks like vessel damage or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

381 people

The number who actually took part.

Started

Oct 2015

Finished

Feb 2017

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years with no upper age limit. * Cerebral infarction in the anterior circulation * Occlusion of the anterior circulation proven by CT angiography or MR angiography * With or without previous Intravenous thrombolysis * Start of thrombectomy procedure within 6 hours of symptoms onset. * Patient expresses verbally his non-opposition to be enrolled in the study ; in case patient cannot communicate, verbal non-opposition is obtained from his close / trusted person Exclusion Criteria: * Absence of indication for thrombectomy * Cons-indication for thrombectomy * Presence of cerebral infarction of the posterior circulation * Occlusion of the cervical carotid artery * Allergy to x-ray contrast products * Patient was bedridden or using a wheelchair most of the day (pre-event modified Rankin Scale score \> 3) prior to stroke * Pregnancy or breastfeeding * Patient under legal protection * No affiliation to health insurance Secondary exclusion criteria \- Lack of access route for catheterization

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Conditions

The condition(s) this trial relates to.

cerebral infarction ischemic stroke large artery stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic cerebrovascular accident

Contacts and locations

Locations

  • CHU Dupuytren

    Limoges, France

  • CHU Hôpital Gui de Chaulac

    Montpellier, France

  • CHU Pellegrin

    Bordeaux, France

  • Fondation Ophtalmologique Adolphe de Rothschild

    Paris, 75019, France

  • Hospices Civils de Lyon

    Bron, France

  • Hôpital Foch

    Suresnes, France

  • Hôpital Guillaume et René LAENNEC

    Nantes, France

  • Hôpital Neurologique

    Nancy, France

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