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Can intensive arm training help stroke survivors regain movement?

NCT ID NCT05527262

Symptom relief Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether intensive upper limb rehabilitation helps people who had a stroke at least 6 months ago. 105 participants were randomly assigned to one of two intensive therapy programs or usual care. The goal was to see if high-dose training improves arm movement and function after 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intensive upper limb rehabilitation programme (Queen Square Upper Limb programme and MindPod Dolphin programme)
What this could lead to
If successful, this could provide strong evidence that intensive arm therapy improves movement and daily function in chronic stroke survivors.
What could go wrong
This is a Phase 2 trial with only 105 participants, so results may not apply to all stroke survivors. The intensive therapy is demanding and may not be feasible for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

105 people

The number who actually took part.

Started

Jul 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. A first-ever unilateral stroke (ischaemic or haemorrhagic) as defined by WHO at least 6-months previously; 2. Moderate upper limb impairment as defined by Fugl-Meyer Upper Extremity (Woodbury et al., 2013) score between 19-46 (to avoid ceiling and floor effects); 3. Must be able to voluntarily extend the thumb and/or 2 or more fingers of the affected hand (10° or more) Exclusion Criteria: 1. Other neurological diagnoses; 2. Serious communication, cognitive and language deficits (\<7 on shortened version Montreal Cognitive Assessment or \< 34 on Cognitive assessment scale for stroke patients); 3. Post-stroke frozen shoulder; 4. Increased muscle tone in wrist/finger extensors (≥3 on Modified Ashworth Scale); 5. Loss of passive range in any upper limb joints; 6. Fatigue of \<30 on the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale; 7. Apraxia score of \<5 on the TULIA assessment; 8. Severe shoulder pain measured by Chedoke Impairment Inventory: Stage of Shoulder Pain 1, 2, and 3; 9. Vision impairment that impedes seeing the television screen

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

Contacts and locations

Locations

  • Nick Ward

    London, WC1N 3BG, United Kingdom

More trials for these conditions

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