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Leg blood flow study reveals clues about stroke recovery

NCT ID NCT05935670

Knowledge-focused Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used gentle leg movements and muscle contractions to measure blood flow. The goal was to learn more about why stroke survivors often have reduced exercise ability and higher risk of another stroke.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Jun 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals Post-Stroke * 18 - 85 years of age * Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis * Able to give informed consent and follow 2-step command. * English Speaking * Age- and Sex-Matched Controls (CON) * Matched to age of individual post- stroke ± 5 years. * Matched to sex of individual post-stroke * Able to give informed consent and follow 2-step command. * English Speaking * Young Healthy Adults (CONyoung) * Age 18-30 years old * Able to give informed consent and follow 2-step command. * English Speaking Exclusion Criteria: * All Groups * Unable to stand from chair and walk 10 meters without physical assistance from another person (able to use assistive device). * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg). * Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization) * Low back or hip pain that limits lower extremity motor testing. * History of head trauma or concussion within the past 6 months * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg * Pregnancy or breastfeeding. * Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator * CON and CONyoung * History of Stroke

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Conditions

The condition(s) this trial relates to.

ischemic disease stroke disorder vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic Stroke Vascular diseases

Contacts and locations

Locations

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.